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The Application of repetitive transcranial magnetic stimulation to the rehabilitation medicine

Research Project

Project/Area Number 10838003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field リハビリテーション科学
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

MANO Yukio  Hokkaido Univ., School of Med., Pro., 医学部, 教授 (20145882)

Co-Investigator(Kenkyū-buntansha) CHUMA Takayo  Hokkaido Univ., School of Med., Inst., 医学部, 助手 (70281805)
WATANABE Ichiro  Hokkaido Univ., Medical Hospital, Asso. Pro., 医学部・付属病院, 助教授 (50241336)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1998: ¥2,900,000 (Direct Cost: ¥2,900,000)
Keywordsrepetitive transcranial magnetic stimulation / ataxia / safety / depression / electroencephalography / parkinsonism / 連続経頭蓋磁気刺激性 / 痙攣 / 筋電図 / SPECT / パーキンソニズム / 運動野 / 小脳 / サイトシンアラピノサイト
Research Abstract

In 1998, in order to examine the safety of repetitive transcranial magnetic stimulation (rTMS), the behavior of mice was analyed. In 32 normal mice (Crj : ICR) and ataxic mice induced by cytosine arabinoside, rTMS with the intensity of 130% motor threshold were given by 10Hz for 10 sec or 3Hz for 60 sec, 5days a week for 3weeks.
The number of movements and falling ratio were measured by open field method. The number of movements decreased in ataxia group compared with control group significantly (p <0,05). There was no difference in number of movement between with rTMS and without rTMS. The falling ratio of group with rTMS 10Hz for 10 sec decreased significantly more than it of group with rTMS of 3Hz for 60 sec and it of group without rTMS. This could be the effect of rTMS to the cerebellar ataxia.
In 1999, the clinical application of rTMS was tried to 6 patients with parkinsonism or involuntary movement, who were treated by conventional medicine. They showed motor disability and psychological depression.
We used rTMS with 0.3Hz, 110〜120% intensity, 60 times a day, 5 days a week for 2 weeks. One patients showed slow EEG during rTMS so we discontinued the trial of rTMS. 4 patients of 5 showed improvement clinically. The main contents of the improvement were the recovery in mood and depression, but also in some motor disability score.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] 中馬孝容: "平山病の経頭蓋磁気刺激法による検討"神経内科. 49(S1). 198-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 木村淳: "高頻度磁気刺激法について本法での動物実験の結果の要約"脳波と筋電図. 26(3). 265-267 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中馬孝容: "mirror movementを呈した症例"臨床脳波. 41(10). 678-681 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 眞野行生: "運動神経系の柔軟性とリハビリテーション"脳の科学. 21. 635-641 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中馬孝容: "パーキンソン病の治療:リハビリテーションの新しい試み"J of Clinical Rehabilitation. 8(11). 1027-1031 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 眞野行生: "MEP(Motor Evoked Potential)"J Clinical Rehab.. 9(3). 268-271 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 眞野行生: "ジストニアの磁気刺激による解析法"Clinical Neuroscience. 17(12). 1308-1309 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mano Yukio: "The effect of repetitive magnetic stimulation on ataxic mice"ELSEVIER, Rrcent Advances in Human Neurophysiology. 969-972 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo: "Magnetic evoked potentials in neck flexion in Hirayama disease"ELSEVIER,Rrcent Advances in Human Neurophysiology. 1014-1017 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo: "The pattern of muscular contraction of biceps brachii elicited by magnetic stimulation"ELSEVIER,Rrcent Advances in Human Neurophysiology. 1018-1021 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo, Mano Yukio: "Magnetic evoked potential in Hirayama disease"Neurological Medicine. 49(S1). 198-199 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Kimura Jun, Mano Yukio, et al.: "The summary of animal study of repetitive transcranial magnetic stimulation."EEG & EMG. 26(3). 265-267 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo, Mano Yukio et al.: "Case report of mirror movement"Clinical EEG. 41(10). 678-681 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mano Yukio: "The flexibility of motor nervous system and rehabilitation"Brain Science. 21. 635-641 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo, Mano Yukio: "A new trial of the rehabilitation for Parkinson disease"J Clinical Rehab.. 8(11). 1027-1031 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mano Yukio, Chuma Takayo: "MEP(Motor Evoked Potential)"J Clinical Rehab.. 9(3). 268-271 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mano Yukio, Ikoma Kazunori: "The analysis of dystonia by magnetic stimulation"Clinical Neuroscience. 17(12). 1308-1309 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Mano Yukio , Chuma Takayo, et al.: "The effect of repetitive magnetic stimulation on ataxic mice."Recent Advances in Human Neurophysiology, ELSEVIER. 969-972 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo: "Magnetic evoked potentials in neck flexion in Hirayama disease."Recent Advances in Human Neurophysiology, ELSEVIER. 1014-1017 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Chuma Takayo, Mano Yukio: "The pattern of muscular contraction of biceps brachii elicited by magnetic stimulation"Recent Advances in Human Neurophysiology, ELSEVIER. 1018-1021 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中馬孝容、眞野行生 他: "mirror movementを呈した症例"臨床脳波. 41(10). 678-681 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 眞野行生: "運動神経系の柔軟性とリハビリテーション"脳の科学. 21. 635-641 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中馬孝容、眞野行生: "パーキンソン病の治療:リハビリテーションの新しい試み"J of Clinical Rehabilitation. 8(11). 1027-1031 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 眞野行生: "高齢者の転倒とその対策"医歯薬出版. 273 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 渡部一郎: "皮膚潰瘍を伴う強皮症患者のリハビリテーション" 臨床リハ. 8(2). 138-143 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 眞野行生: "脳血管障害のリハビリテーション・大脳半球機能との関連について" 室医報. 8. 21-23 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 眞野行生: "運動療法" 日本内科学会雑誌. 87(9). 1916-1920 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 渡部一郎: "外来リウマチ患者の転倒と病態の関連" 臨床リウマチ. 10(3). 184-190 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中馬孝容: "平山病の経頭蓋的磁気刺激法による検討" 神経内科. 49(51). 198-199 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] MANO Y.: "Recent Advances in Human Neurophysiology (The effect of repetitive magnetic stimulation on ataxic mice)" ELSEVIER SCIENCE B.V. (ed.by Hashimoto I.and Kakigi R.), 1106 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Chuma T.: "Recent Advances in Human Neurophysiology (Magnitic evoked potentials in neck flexion)" ELSEVIER SCIENCE B.V. (ed.by Hashimoto I.and Kakigi R.), 1106 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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