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Recovery of motor function by noninvasive stimulation of the human brain.

Research Project

Project/Area Number 10838039
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field リハビリテーション科学
Research InstitutionTokai University

Principal Investigator

IZUMI Shin-ichi  Tokai University Department of Rehabilitation Medicine Associate Professor, 医学部, 助教授 (80176239)

Co-Investigator(Kenkyū-buntansha) ISHIDA Akira  Tokai University Department of Rehabilitation Medicine Professor, 医学部, 教授 (50118907)
Project Period (FY) 1998 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥3,500,000 (Direct Cost: ¥3,500,000)
Fiscal Year 2000: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1999: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1998: ¥2,400,000 (Direct Cost: ¥2,400,000)
Keywordstranscranial magnetic stimulation / stroke / hemiplegia / facilitation / safety / reorganization / motor area / electroencephalography / 脳血管障害 / 運動誘発電位 / 随意運動
Research Abstract

1) We established EEG monitoring system during TMS for patients with risk of epilepsy. First, we determined the changes and responses in the electroencephalogram (EEG) induced by transcranial magnetic stimulation (TMS) of the scalp of stroke patients. To reduce stimulus artifacts, we created a circuit that blocked the input for 150 msec after stimulation. No epileptiform afterdischarges or sharp wave potentials were observed. After this preliminary study, we revised the artifact-reducing circuit so as to record EEG 50 msec after stimulation.
2) We investigated facilitation in voluntary movement, and demonstrated that facilitation occurs during voluntary contraction of antagonist or other heteronymous muscles. It also was found that the degree of facilitation induced by a heteronymous muscle contraction differed between individual muscles, and between dominant and nondominant forearm muscles.
3) We investigated short-term effects of TMS over the frontal lobe on cognitive function such as … More frontal lobe function, attention, and memory, and EEG of healthy subjects. Then, we concluded that TMS has no adverse effects on cognitive and electrophysiologic function.
4) One stroke patient (48 years of age, male, left putaminal hemorrhage, right hemiplegia for 3 years and 4 months) provided his informed consent to participate in this study. TMS (0.1 Hz, 100 stimuli) were delivered over the motor cortex every week for 3 months. The subject was instructed to make efforts of contracting the target muscle (facilitation) when stimulated. Before stimulation the subject could flex fingers (mass flexion), and extend the little finger less than 5 degrees (Brunnstrom stage 3). After stimulation the subject could extend all the fingers and thumb except the index finger, and move the little finger separately. TMS could not evoke motor responses during the first three sessions. Motor responses evoked by TMS appeared at the 4th session, and amplitudes of the motor evoked potentials increased gradually. No epileptiform afterdischarges or sharp wave potentials were observed. In the future study effectiveness of TMS will be investigated in a rondomized control study and an indication of TMS for treatment of hemiplegia will be suggested. Less

Report

(4 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • 1998 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] Shin-Ichi Izumi: "Effect of antagonistic voluntary contraction on motor responses in the forearm"Clinical Neurophysiology. 111. 1008-1014 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shin-Ichi Izumi: "Effects of antagonistic voluntary contraction on motor evoked potentials in the forearm differ between dominant and nondominant sides"Electrophysiology and Kinesiology (edited by Yukio Mano and Morihiro Okada), Monduzzi Editore,Bologna. 1st ed.. 95-98 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shin-Ichi Izumi: "Effect of antagonistic voluntary contraction on motor responses in the leg"Recent Advances in Human Neurophysiology (edited by Isao Hashimoto and Ryusuke Kakigi), Elesevier, Amsterdam. 1st ed.. 1005-1013 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shin-Ichi Izumi: "Transcranial magnetic stimulation-induced changes in scalp-recorded EEG and evoked responses in patients with cerebrovascular disease"Japan Journal of Rehabilitation Medicine. 35. 738-743 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 古川俊明: "大腿四頭筋の随意収縮による下腿筋への促通現象の検討"Journal of Clinical Rehabilitation. 9. 640-643 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 古川俊明: "異名筋の随意収縮による促通現象の検討-大腿四頭筋と足関節背屈筋について-"Journal of Clinical Rehabilitation. 8. 1218-1221 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi SI, Koyama Y, Ishida A, Findley TW: "Effect of antagonistic voluntary contraction on motor responses in the leg."In Hashimoto I and Kakigi R (eds) : Recent Advances in Human Neurophysiology. Elesevier ; Amsterdam. 1005-1013 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi SI, Takase M, Chino N, Arita M, Ishida A: "Transcranial magnetic stimulation-induced changes in scalp-recorded EEG and evoked responses in patients with cerebrovascular disease."Jpn J Rehabil Med. 11. 738-743 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi SI, Koyama Y, Furukawa T, Ishida A: "Effect of antagonistic voluntary contraction on motor responses in the forearm."Clin Neurophysiol. 111. 1008-1014 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Izumi SI, Arita M, Kimura A, Chino N: "Effects of antagonistic voluntary contraction on motor evoked potentials in the forearm differ between dominant and nondominant sides."In Mano Y and Okada M (eds) : Electrophysiology and Kinesiology. Monduzzi Editore. Bologna. 95-98 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Furukawa T, Izumi SI, Ishida A: "Heteronymous facilitation : effects of voluntary ankle dorsal and plantar flexion on motor responses and myoelectric activities in the ipsilateral quadriceps fomoris muscle."J Clin Rehabil. 8. 1218-1221 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Furukawa T, Izumi SI, Ishida A: "Facilitatory effects of ipsilateral quadriceps femoris voluntary contraction on motor responses and myoelectric activities in the tibialis anterior and soleus muscles."J Clin Rehabil. 9. 640-643 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Shin-Ichi Izumi: "Effect of antagonistic voluntary contraction on motor responses in the forearm"Clinical Neurophysiology. 111・6. 1008-1014 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shin-Ichi Izumi: "Effects of antagonistic voluntary contraction on motor evoked potentials in the forearm differ between dominant and nondominant sides"Electrophysiology and Kinesiology (edited by Yukio Mano and Morihiro Okada), Monduzzi Editore, Bologna. 1st ed.. 95-98 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 古川俊明: "大腿四頭筋の随意収縮による下腿筋への促通現象の検討"Jouranal of Clinical Rehabilitation. 9・6. 640-643 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Izumi S, et al.: "Effect of antagonistic voluntary contraction on motor responses in the forearm"Clinical Neurophysiology. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] 古川俊明、他: "異名筋の随意収縮による促通現象の検討-大腿四頭筋と足関節底背屈筋について-"Journal of Clinical Rehabilitation. 8・12. 1218-1221 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Izumi S,Takase M,Chino N,Arita M,Ishida A: "Transcranial magnetic stimulation-induced changes in scalp-recorded EEG and evoked responses in patients with cerebrovascular disease" Jpn J Rehabil Med. 35・11. 738-743 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Izumi S,Koyama Y,Ishida A,Findley TW: "Effect of antagonistic voluntary contraction on motor responses in the leg" Recent Advances in Human Neurophysiology,Internatinal Congress Series. 1162. 1005-1013 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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