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Investigation of the mechanism of intervertebral

Research Project

Project/Area Number 10839010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 動物臨床医学
Research InstitutionYamaguchi University

Principal Investigator

TAURA Yasuho (1999)  Faculty of Agriculture, Yamaguchi University, Professor, 農学部, 教授 (80163153)

中間 實徳 (1998)  山口大学, 農学部, 教授 (90081596)

Co-Investigator(Kenkyū-buntansha) UNE Satoshi  Faculty of Agriculture, Yamaguchi University, Research Associate, 農学部, 助手 (60294659)
NAKAICHI Munekazu  Faculty of Agriculture, Yamaguchi University, Associate Professor, 農学部, 助教授 (60243630)
田浦 保穂  山口大学, 農学部, 教授 (80163153)
Project Period (FY) 1998 – 1999
Project Status Completed (Fiscal Year 1999)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1998: ¥2,800,000 (Direct Cost: ¥2,800,000)
KeywordsDog / Intervertebral disc herniation / Nucleus pulposus / Chondrodystrophoid / Non-chondrodystrophoid / Cathepsin L / MRI / Cystein proteinases / システインプロティナーゼ
Research Abstract

In this research, we investigated the cause of degeneration intervertebral disc (IVD) and the mechanism of IVD herniation in dogs by means of magnetic resonance imaging (MRI) in Yamaguchi University Hospita. We divided two study groups in which were chondrodystrophoid (CHD) breed, such as dachshund or beagle, and non-chondrodystrophoid (NCHD) breed, such as maltese. In IVD of CHD breed, the signal intensity of T2-weighted image was higher than that of NCHD. This was suggested that there were more moistly in IVD of CHD than that of NCHD because there were chondrocyte in the nucleus pulposus in CHD and not in NCHD. Then we investigated the biochemical activity of several cystein proteinases in the nucleus pulposus (NP), which was center of IVD, and anulus fibrosus (AF), which was surround of NP, by means of biochemical analysis. In IVD of beagle dog which was CHD group, there were much more cathepsin L than cathepsin B, which both proteinase were a member of cystein proteinase family. And proteinase activity was higher at NP than AF in each proteinases. These results suggested that the mechanism of IVD degeneration and/or herniation was related to region specificity or pH specificity because of cathepsin L activity was higher at acidic region. This may be important key to investigate the cause of IVD degenetation and herniation in dogs.

Report

(3 results)
  • 1999 Annual Research Report   Final Research Report Summary
  • 1998 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 田賀淳夫: "イヌの嚢腫性二分脊椎症の脊髄造影X線およびMRI所見"日獣会誌. 51. 81-84 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 田賀淳夫: "イヌの嚢腫性二分脊椎症例に対する背側椎弓切除術および皮膚洞切除術"日獣会誌. 51. 591-594 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Taga,A.: "The advantage of magnetic resonance imaging in diagnosis of cauda equina syndrome in dogs"J.Vet.Med.Sci.. 60. 1345-1348 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Taga,A.: "Magnetic resonance imaging of syringomyelia in five dogs"J.Small Animal Practice. 41(accepted). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] 中間實徳: "小動物の脊椎・椎間板疾患:診断と治療(中間實徳 監修)"インターズー. 211 (1998)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsuo TAGA: "Myelography and magnetic resonance imaging (MRI) of Spina Bifid Cystica in a dog"J. Japan. Vet. Med. Assoc.. 51. 81-84 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsuo TAGA: "Effect of dorsal laminectomy and dermal sinus resection in a dog with Spina Bifida Cystica"J. Japan. Vet. Med. Assoc.. 51. 591-594 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsuo TAGA: "The advantage of magnetic resonance imaging in Diagnosis of Cauda Equina Syndrome in dogs"J. Vet. Med. Sci.. 60. 1345-1348 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Atsuo TAGA: "Magnetic Resonance imaging of syringomielia in five dogs"J. Small Animal Practice. 41(in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Sanenori NAKAMA: "Spinal diseases in small animals : Diagnosis and treatment"Inter Zoo. 211 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1999 Final Research Report Summary
  • [Publications] Taga,A,Taura,Y: "Magnetic resonance imaging of syringomyelia in fivu dogs"J.Small Animal Practice. 41(accepted). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 田賀淳夫・田浦保穂: "犬の嚢腫性二分脊椎症の脊髄造影X線およびMRI所見" 日獣会誌. 51(2). 81-84 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田賀淳夫・田浦保穂: "犬の嚢腫性二分脊椎症例に対する背側椎弓切除術および皮膚洞切除術" 日獣会誌. 51(10). 591-594 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] Taga,A.・Taura,Y.: "The advantage of magnetic resonanoe imaging in diagnosis of cauda equina syndrome in dogs" J.Vet.Med.Sci.60(12). 1345-1348 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田浦保穂: "神経(脊椎・脊髄)疾患の治療" ProVet. 125. 39-47 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田浦保穂: "骨格標本で示す骨外科手技(9)胸腰椎の骨折に対するルブラプレート法およびステープリング法による椎体固定術" Surgeon. 2(4). 66-70 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田浦保穂: "骨格標本で示す骨外科手技(10)ウォブラー症候群に対する外科手術的治療法" Surgeon. 2(5). 77-81 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田浦保穂: "骨格標本で示す骨外科手技(11)環椎・軸椎亜脱臼に対する外科手術的治療法" Surgeon. 2(6). 84-87 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中間實徳: "小動物の脊椎・椎間板疾患:診断と治療(中間實徳監修)" インターズー, 211 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 田浦保穂: "小動物の脊椎・椎間板疾患:診断と治療(中間實徳監修)" インターズー, 211 (1998)

    • Related Report
      1998 Annual Research Report
  • [Publications] 中市統三: "小動物の脊椎・椎間板疾患:診断と治療(中間實徳監修)" インターズー, 211 (1998)

    • Related Report
      1998 Annual Research Report

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Published: 1998-04-01   Modified: 2016-04-21  

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