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バングラディッシュ国閉経期女性の高血圧リスク因子に関する社会統計学及び遺伝学的研究

Research Project

Project/Area Number 10F00517
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section外国
Research Field Public health/Health science
Research InstitutionResearch Institute, International Medical Center of Japan

Principal Investigator

木村 壯介 (2010, 2012)  独立行政法人国立国際医療研究センター, 病院, 院長

木村 壮介 (2011)  国立国際医療研究センター, 院長

Co-Investigator(Kenkyū-buntansha) ISLAM A.M.Shahidul  国立国際医療研究センター, 遺伝子診断治療開発研究部, 外国人特別研究員
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2012: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 2011: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsバングラデシュ / 農村部 / 高血圧 / メタボリック症候群 / 危険因子 / 社会経済的 / 遺伝的 / 閉経後
Research Abstract

具体的内容
我々はバングラデシュ農村部で横断研究を行い、最終年度として、サンプルやアンケート調査票を解析し研究結果をまとめた。
意義
我々は,この3年間で、社会経済的、人口動態学的調査、医学的健診、医学的採血検査を実施。15歳以上で合計3900人に施行。このうち、閉経後女性は1382人である。
1)バングラデシュ国の閉経後女性における高血圧症の有病率1382名中、高血圧診断基準は49.2%が満たした。
2)高血圧症関連リスク因子
参加者の内、相当数は、メタボリック症候群(MS)、高BMI値、高血圧、高インシュリン血症、HDL低値を示した。特に、本研究の主な対象である閉経後女性においては、MSは高率であり、39.65%であった。高血圧女性は、非高血圧者に対して、比較的に高齢であった。閉経後女性における高血圧群は、LDLコレステロール、収縮期血圧,拡張期血圧,空腹時血糖値,および空腹時インシュリン値において、非高血圧群の女性よりも、統計学的有意差をもって高値を示した。HDLコレステロール低値を示した。中性脂肪と総コレステロールの何れも、高血圧群では非高血圧群よりも高い傾向が見られた。非HDLコレステロールは、統計学的有意差をもって、高血圧群にて高値であった。高い社会経済的状況と低い身体活動性は、統計学的有意差をもってMSと高血圧に正相関を示した。即ち、高い所有土地面積、高い住居面積、低い身体活動性は、MSと高血圧との相関を示した。高齢、高血圧や糖尿病の家族歴は、MSと高血圧のリスクであった。一方、高い教育歴は、健康への高い関心とリスクの軽減に相関が見られた。
重要性
バングラデシュ国においては、現状では健康政策的な方針に乏しく、今回の調査結果を具体的な提言につなげたい。バングラデシュ国をはじめとする東南アジア諸国においては、今後の経済的発展に伴う生活習慣病の爆発的増大が懸念されている。この度の研究から得られた所見は、社会経済的な側面における改善や、住民の行動変容や生活習慣の具体的改善の必要性を示唆すると考えられる。それらは、今後の遺伝子多型解析結果などを介して、我々日本人における同様な改善策の政策的立案にも活用できる可能性を有する。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

我々は、予定通りに調査研究を行い、データの解析を行った。

Strategy for Future Research Activity

我々は、当初の予定通り調査研究を行い、最終年度として成果が得られた。

Report

(3 results)
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (24 results)

All 2013 2012 2011

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (15 results)

  • [Journal Article] Disruption of components of vascular endothelial growth factor angiogenic signalling system in metabolic syndrome. Findings from a study conducted in rural Bangladeshi women.2013

    • Author(s)
      Jesmin, Hiroe, et al.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 109(4) Issue: 04 Pages: 696-705

    • DOI

      10.1160/th12-09-0654

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic syndrome among pre and post menopausal rural women in Bangladesh : result from a population based-study.2013

    • Author(s)
      Jesmin/ Islam, et al.
    • Journal Title

      BMC Research Notes

      Volume: 6(Epub ahead of print) Pages: 157-157

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disruption of VEGF system in metabolic syndrome.2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Journal Title

      Physiology Research

      Volume: 61 Pages: 4-4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive assessment of metabolic syndrome among rural Bangladeshi women2012

    • Author(s)
      S.Jesmin, MR.Islam, AMS.Islam
    • Journal Title

      BMC Public Health

      Volume: 12:49 Issue: 1 Pages: 1-11

    • DOI

      10.1186/1471-2458-12-49

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessing metabolic syndrome among pre and post menopausal women of Bangladesh.2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Journal Title

      Physiology Research

      Volume: 61 Pages: 2-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of age at menarche with metabolic syndrome and its components in rural Bangladeshi women.2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Journal Title

      BMC Nutrition and Metabolism

      Volume: 9:9(1) Issue: 1 Pages: 99-99

    • DOI

      10.1186/1743-7075-9-99

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevalence of metabolic syndrome among rural Bangladeshi women2012

    • Author(s)
      S.Jesmin, MS.Mia, AMS.Islam, …S.Kimura
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 95:1 Issue: 1 Pages: e7-e9

    • DOI

      10.1016/j.diabres.2011.09.025

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-dependent alterations of VEGF and its signaling molecules in acute lung injury in a rat model of sepsis2011

    • Author(s)
      S.Jesmin, S.Zaedi, AMS.Islam
    • Journal Title

      Inflammation

      Volume: Apr 29.(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Excluded Childhood and Strategic Response in Bangladesh : Assessment on Child Workers and Child Abuse Issues2011

    • Author(s)
      AMS.Islam
    • Journal Title

      Tsukuba Annals of Sociology

      Volume: 3.4 Pages: 66-76

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Estimation of prevalence of gestational diabetes mellitus ID Rural Bangladesh2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Organizer
      First Euro-India International Conference on Diabetes
    • Place of Presentation
      Kerala, India
    • Year and Date
      2012-04-09
    • Related Report
      2012 Annual Research Report
  • [Presentation] An investigation to search for the innovative social approach for health improvement beyond MDG in Bangladesh2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Organizer
      39th annual congress of Japanese Society of Health and Social Medicine
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] A cross sectional study of prevalence of gestational diabetes mellitus in arural population of Bangladesh2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Organizer
      39th annual congress of Japanese Society of Health and Social Medicine
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of Socioeconomic Status on Metabolic Syndrome, (Results from Rural Bangladesh)2012

    • Author(s)
      Jesmin/ Islam, et al.
    • Organizer
      39th annual congress of Japanese Society of Health and Social Medicine
    • Place of Presentation
      Kobe, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] Socioeconomic Status Matters for Metabolic Syndrome in Rural Women of Bangladesh2011

    • Author(s)
      AMS.Islam, S.Jesmin, S.Kimura
    • Organizer
      Asia Pacific Conference on the Metabolic Syndrome (APCMS)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalence of Metabolic Syndrome with Menopausal Reference of Rural Women in Bangladesh2011

    • Author(s)
      AMS.Islam, S.Jesmin, …S.Kimura
    • Organizer
      Asia Pacific Conference on the Metabolic Syndrome (APCMS)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] VEGF system in metabolic syndrome : Findings from a Population-Based study of Bangladeshi rural women2011

    • Author(s)
      AMS.Islam, S.Jesmin, …S.Kimura
    • Organizer
      Asia Pacific Conference on the Metabolic Syndrome (APCMS)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalence of Metabolic Syndrome in Bangladeshi Rural Women2011

    • Author(s)
      AMS.Islam, S.Jesmin, …S.Kimura
    • Organizer
      Asia Pacific Conference on the Metabolic Syndrome (APCMS)
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prevalence of Metabolic Syndrome in Pre- and Post-Menopausal Rural Women of Bangladesh : Result from a Population-Based Study2011

    • Author(s)
      AMS.Islam, S.Jesmin, …
    • Organizer
      The 47th Annual Meeting of the Society for Hypertension Related Disease Model Research
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Disruption of VEGF system in metabolic syndrome2011

    • Author(s)
      S.Jesmin, H.Togashi, AMS.Islam, …
    • Organizer
      The 47th Annual Meeting of the Society for Hypertension Related Disease Model Research
    • Place of Presentation
      Sapporo, Japan
    • Related Report
      2011 Annual Research Report
  • [Presentation] Socioeconomic Status and Metabolic Syndrome among Rural Women of Bangladesh2011

    • Author(s)
      AMS.Islam, S.Kimura
    • Organizer
      Controversies to Consensus in Diabetes, Obesity and Hypertension(CODHy)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Level of TNF-α in metabolic syndrome in Bangladeshi rural women2011

    • Author(s)
      MS.Mia, S.Jesmin, MR Islam, AMS.Islam
    • Organizer
      Controversies to Consensus in Diabetes, Obesity and Hypertension (CODHy)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of Metabolic Syndrome in Pre-and Post-Menopausal Rural Women of Bangladesh : Result from a Population-Based Study2011

    • Author(s)
      MR.Islam, S.Jesmin, AMS.Islam, S.Kimura
    • Organizer
      Controversies to Consensus in Diabetes, Obesity and Hypertension(CODHy)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Circulating levels of VEGF and its receptors, sVEGF-R1 and sVEGF-R2 inmetabolic syndrome in Bangladeshi rural women2011

    • Author(s)
      S.Jesmin, AMS.Islam S.Kimura, S.Jesmin
    • Organizer
      Controversies to Consensus in Diabetes, Obesity and Hypertension(CODHy)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report
  • [Presentation] Prevalence of Metabolic Syndrome among Rural Bangladeshi Women2011

    • Author(s)
      MR.Islam, AMS.Islam
    • Organizer
      Controversies to Consensus in Diabetes, Obesity and Hypertension(CODHy)
    • Place of Presentation
      Shanghai, China
    • Related Report
      2010 Annual Research Report

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Published: 2010-12-03   Modified: 2024-03-26  

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