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運動トレーニングによる女性の暑熱耐性向上のメカニズム-換気・脳血流反応に着目-

Research Project

Project/Area Number 10J00018
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Research Field Sports science
Research InstitutionKobe University

Principal Investigator

藤井 直人  神戸大学, 大学院・人間発達環境学研究科, 特別研究員(PD)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2012: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2011: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2010: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywords女性 / 運動トレーニング / 換気亢進反応
Research Abstract

近年,深部体温上昇に伴う換気亢進反応により動脈血二酸化炭素分圧が低下し,この分圧低下が暑熱下での脳血流量低下に関与することが示唆された.過度な脳血流量低下は失神を招くため,この換気亢進による脳血流量低下が熱中症発生に関係している可能性が考えられる.しかしこの反応については十分に明らかでなく,特に女性の反応については不明な点が多い.これまでの研究では,運動時の体温上昇時の換気亢進反応は自転車運動時でのみ検討されており,異なる運動,例えばランニング時の反応は全く検討されてこなかった.さらに,ランニング時の体温上昇に伴う換気亢進反応が,男性と女性で異なるか,さらには有酸素能力と関係するかは明らかでない.今年度は上記の不明な点を明らかにするため実験を行った.被験者は普段ランニングを定期的に行っている男女であった.気温32℃,湿度40%に設定した環境制御室下で,60%VO2max強度のランニングを45分間行った.深部体温と換気量の回帰直線の傾きで評価される体温上昇時の換気亢進反応は,これまでに評価されている先行研究での自転車運動時のそれと同様であった.また,ランニング時の体温上昇時の換気亢進反応は男女間で違いは見られなかった.しかし,運動時の絶対的運動強度,すなわち代謝量は男性より女性の方が低いことから,体温上昇時の過換気によって低下する動脈血二酸化炭素分圧,さらに脳血流量低下は男性より女性で大きくなる可能性が考えられる.さらに,男女いずれにおいても,ランニング時の体温上昇時の換気亢進反応はVO2maxとの有意な相関関係は見られず,これは自転車運動時の知見とは異なるものであった(自転車運動時の体温上昇時の換気亢進反応は,VO2maxと有意な相関関係が見られている).

Report

(3 results)
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (49 results)

All 2013 2012 2011 2010

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (34 results) Book (1 results)

  • [Journal Article] Impaired acetylcholine-induced cutaneous vasodilation in young smokers : roles of nitric oxide and prostanoids.2013

    • Author(s)
      Fujii N, Reinke MC, Brunt VE & Minson CT
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 304(5) Issue: 5 Pages: H667-H673

    • DOI

      10.1152/ajpheart.00731.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans2013

    • Author(s)
      Fujii N. Ichinose M, Honda Y,Tsuji B, Watanabe K, Kondo N & Nishi yasu T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 113 Issue: 1 Pages: 51-62

    • DOI

      10.1007/s00421-012-2413-x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans2012

    • Author(s)
      Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N & Nishiyasu T
    • Journal Title

      Am J Physiol Regul integr Comp Physiol

      Volume: 303 Issue: 9 Pages: R975-R983

    • DOI

      10.1152/ajpregu.00169.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of hyperthermic hyperventilation during passive heating and prolonged light and moderate exercise in the heat2012

    • Author(s)
      Tsuji B, Honda y Fujii N. Kondo N & Nishiyasu T
    • Journal Title

      J Appl Physiol

      Volume: 113(9) Issue: 9 Pages: 1388-1397

    • DOI

      10.1152/japplphysiol.00335.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 800-m and 1500-m run times relate to anaerobic performance in competitive runners2012

    • Author(s)
      Fujii N, Ogawa T, Ichinose M, Hayashi K, Nishiyasu T
    • Journal Title

      Gazzetta Medica Italiana Archivio per le Scienze Mediche

      Volume: (In press)(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Short-term exercise-heat acclimation enhances skin vasodilation but not hyperthermic hyperpnea in humans exercising in a hot environment2012

    • Author(s)
      Fujii N, Honda Y, Ogawa T, Tsuji B, Kondo N, Koga S, Nishiyasu T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 112(1) Issue: 1 Pages: 295-307

    • DOI

      10.1007/s00421-011-1980-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of initial core temperature on hyperthermic hyperventilation during prolonged submaximal exercise in the heat2012

    • Author(s)
      Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T
    • Journal Title

      American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

      Volume: 302(1) Issue: 1 Pages: R94-R102

    • DOI

      10.1152/ajpregu.00048.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] エネルギー代謝と運動時の体温調節2011

    • Author(s)
      近藤徳彦, Glen Kenny, 天野達郎, 藤井直人, 西保岳
    • Journal Title

      体育の科学

      Volume: 61(8) Pages: 589-594

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 陸上中距離競技者における800m及び1500m走タイムと無酸素的運動パフォーマンスの関係2011

    • Author(s)
      藤井直人、小川剛司、西保岳
    • Journal Title

      陸上競技研究

      Volume: 84 Pages: 2-12

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The effect of CO2 on the ventilatory sensitivity to rising body temperature during exercise.2011

    • Author(s)
      Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, Nishiyasu T.
    • Journal Title

      Journal of Applied Physiology

      Volume: In press

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comments on point : counterpoint : humans do/do not demonstrate selective brain cooling during hyperthermia2011

    • Author(s)
      Nishiyasu T, Fujii N, Hayashi K, Tsuji B.
    • Journal Title

      Journal of Applied Physiology

      Volume: 110 Pages: 578-579

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 中枢性疲労と体温上昇時の換気亢進反応2010

    • Author(s)
      藤井直人、近藤徳彦、西保岳
    • Journal Title

      体育の科学

      Volume: 60 Pages: 824-827

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Individual differences in the heart rate response to activation of the muscle metaboreflex in humans2010

    • Author(s)
      Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T
    • Journal Title

      American Journal of Physiology

      Volume: 299(5)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of breathing a helium-oxygen gas mixture on maximal pulmonary ventilation and maximal oxygen consumption during exercise in acute moderate hypobaric hypoxia.2010

    • Author(s)
      Ogawa T, Calbet JA, Honda Y, Fujii N, Nishiyasu T
    • Journal Title

      European Journal of Applied Physiology

      Volume: 110(4) Pages: 853-861

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 安静時暑熱暴露による暑熱順化が暑熱下運動時の換気反応に及ぼす影響2012

    • Author(s)
      辻文, 本田靖, 藤井直人, 近藤徳彦, 西保岳
    • Organizer
      第67回日本体力医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-09-14
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of passive heat acclimation on hyperthermic hyperventilation during prolonged exercise in the heat2012

    • Author(s)
      Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T
    • Organizer
      The Systems Biology of Exercise : Cardiorespiratory & Metabolic Integration
    • Place of Presentation
      Leeds, UK
    • Year and Date
      2012-08-16
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effect of voluntary hypocapnic hyperventilation on thermoregulatory responses in exercising humans2012

    • Author(s)
      Fujii N, Honda Y, Komura K, Tsuji B, Sugihara A, Watanabe K, Kondo N, Nishiyasu T
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-04-24
    • Related Report
      2012 Annual Research Report
  • [Presentation] 安静加温時における動脈血圧反応と換気亢進反応との関係2011

    • Author(s)
      藤井直人, 一之瀬真志, 辻文, 渡邉和仁, 近藤徳彦, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋代謝受容器反射活性時における動脈圧受容器反射による心拍調節機能:活動部位の違いに着目して2011

    • Author(s)
      渡邊和仁, 一之瀬真志, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] 暑熱下運動時における換気亢進反応の日内変動に及ぼす運動前深部体温の影響2011

    • Author(s)
      辻文, 藤井直人, 近藤徳彦, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低酸素下における漸増負荷運動時の呼吸筋の仕事量2011

    • Author(s)
      小川剛司, 槇幸実, 藤井直人, 辻文, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] 筋代謝受容器刺激時における急性の動脈血圧低下に対する循環反応2011

    • Author(s)
      一之瀬真志, 渡邊和仁, 藤井直人, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水球競技選手における最大下及び最大巻き足運動時の心拍及び呼吸代謝応答に関する研究2011

    • Author(s)
      佐々木洋輔, 藤井直人, 辻文, 西保岳
    • Organizer
      第19回日本運動生理学会大会
    • Place of Presentation
      徳島大学常三島キャンパス
    • Related Report
      2011 Annual Research Report
  • [Presentation] The influence of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans2011

    • Author(s)
      Fujii, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N, Nishiyasu T
    • Organizer
      International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio (Greece)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effect of additional warm-up on performance and physiological responses during 2-min maximal exercise2011

    • Author(s)
      Sasaki Y, Ueki T, Tsuji B, Fujii N, Takagi H, Tsubakimoto S, Nishiyasu T
    • Organizer
      International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio (Greece)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circadian variation In hyperthermic hyperventilation during exercise and pre-exercise resting core temperature2011

    • Author(s)
      Tsuji B, Honda Y, Sugihara A, Watanabe K, Niwa T, Fujii N, Kondo N, Nishiyasu T
    • Organizer
      International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio (Greece)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heart rate during graded activation of the muscle metaboreflex in humans2011

    • Author(s)
      Watanabe K, Ichinose M, Delliaux S, Fujii N, Nishiyasu T
    • Organizer
      International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio (Greece)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hypervolemia from Fluid Ingestion at Rest-Effects of Sodium and Glucose-2011

    • Author(s)
      Sugihara A, Fujii N, Tsuji B, Watanabe K, Niwa T, Nishiyasu T
    • Organizer
      International Conference on Environmental Ergonomics
    • Place of Presentation
      Nafplio (Greece)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Arterial blood pressure response to severe passive heating at rest relates to hyperthermia-induced hyperventilation in humans2011

    • Author(s)
      Fujii N, Ichinose M, Honda Y, Tsuji B, Watanabe K, Kondo N, Nishiyasu T
    • Organizer
      European College of Sport Science Conference
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circadian variation in hyperthermic hyperventilation during prolonged exercise in the heat2011

    • Author(s)
      Tsuji B, Honda, Y, Fujii N, Kondo N, Nishiyasu T
    • Organizer
      European College of Sport Science Conference
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Spontaneous baroreflex control of heat rate during activation of the muscle metaboreflex in the forearm and calf in humans2011

    • Author(s)
      Watanabe K, Ichinose M, Fujii N, Tsuji B, Sugihara A, Niwa T, Nishiyasu T
    • Organizer
      European College of Sport Science Conference
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cardiorespiratory and metabolic responses during maximal and submaximal eggbeater kicking by water polo players2011

    • Author(s)
      Sasaki Y, Takagi H, Fujii N, Tsuji B, Tsubakimoto S, Nishiyasu T
    • Organizer
      European College of Sport Science Conference
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of pre-exercise ingestion of sodium and glucose on physiological responses and performance during exercise in the heat2011

    • Author(s)
      Sugihara A, Fujii N, Tsuji B, Watanabe K, Niwa T, Nishiyasu T
    • Organizer
      European College of Sport Science Conference
    • Place of Presentation
      Liverpool (UK)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The effects of short-term exercise training on cardiorespiratory and ther moregulatory responses2010

    • Author(s)
      Fujii N
    • Organizer
      Body and Mind Integrated Science (BAMIS) seminar
    • Place of Presentation
      筑波大学(茨城県)
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] The differential effects of exercise training in cold and hot environment on ventilatory and cerebrovascular responses in resting heated humans2010

    • Author(s)
      Fujii N, Honda Y, Tsuji B, Kondo N, Koga S, Nishiyasu T.
    • Organizer
      ACSM's Integrative Physiology of Exercise conference
    • Place of Presentation
      Eden Roc A Renaissance Beach Resort & Spa (USA)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypercapnic Chemoreflex And Muscle Metaboreflex Interactions : Effects on Heart.2010

    • Author(s)
      Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T.
    • Organizer
      ACSM's Integrative Physiology of Exercise conference
    • Place of Presentation
      Eden Roc A Renaissance Beach Resort & Spa (USA)
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 体温上昇時における皮膚血流及び脳血流反応に及ぼす自発的過換気の影響2010

    • Author(s)
      藤井直人、辻文、渡邊和仁、近藤徳彦、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉眼)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高機能タイツ着用による下肢圧迫が安静加温時の上肢皮膚血管拡張反応に及ぼす影響2010

    • Author(s)
      二川俊哉、辻文、藤井直人、近藤徳彦、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 筋代謝受容器反射の活性レベルの差異が循環調節に及ぼす影響2010

    • Author(s)
      渡邊和仁、一之瀬真志、藤井直人、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 概日リズムによる体温変動が暑熱下運動時の換気反応に及ぼす影響2010

    • Author(s)
      辻文、藤井直人、近藤徳彦、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 陸上中距離選手における低圧下高強度間欠的走運動時の呼吸代謝応答及びパフォーマンス-無酸素代謝と気道抵抗軽減の影響-2010

    • Author(s)
      及川将太、藤井直人、丹羽岳悠、小川剛司、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 飲料摂取後の暑熱下運動時の生理反応及びパフォーマンスに関する研究-飲料のNa+と糖に着目-2010

    • Author(s)
      杉原輝、藤井直人、辻文、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトの動的運動時における筋代謝受容器反射の特性2010

    • Author(s)
      一之瀬真志、渡邊和仁、藤井直人、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低圧下での最大運動時の呼吸代謝応答~気圧低下の効果に注目して~2010

    • Author(s)
      小川剛司、藤井直人、辻文、西保岳
    • Organizer
      第65回日本体力医学会大会
    • Place of Presentation
      千葉商科大(千葉県)
    • Year and Date
      2010-09-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトにおける体温上昇時の換気反応の特性と生理学意義2010

    • Author(s)
      藤井直人
    • Organizer
      第24回呼吸研究会
    • Place of Presentation
      和洋女子大学(千葉県)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 学会大会を考える(Next 10yearsに向けて)「若手研究者からの立場から学会大会のあり方の提案」2010

    • Author(s)
      藤井直人
    • Organizer
      第61回日本体育学会
    • Place of Presentation
      中京大学(愛知県)
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Muscle Metaboreflex Functions During Dynamic Exercise in Humans2010

    • Author(s)
      Ichinose M, Watanabe K, Delliaux S, Fujii N, Nishiyasu T.
    • Organizer
      The 57th Annual Meeting of the American College of Sports Medicine
    • Place of Presentation
      Indianapolis, Baltimore, USA
    • Year and Date
      2010-06-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトと動物における体温上昇時の換気反応2010

    • Author(s)
      藤井直人, 本田靖, 西保岳
    • Organizer
      日本生理人類学会第62回大会
    • Place of Presentation
      大阪国際大学(大阪府)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Book] 体温II-体温調節システムとその適応-第3章(体温調節システムと呼吸調節)2010

    • Author(s)
      藤井直人、西保岳
    • Publisher
      NAP
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-12-03   Modified: 2024-03-26  

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