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ELUCIDATION OF HEPATOCARINOGENESIS IN HEPATITIS C VIRUS INFECTION USING TRANSGENIC MICE.

Research Project

Project/Area Number 11138213
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

KOIKE Kazuhiko  TOKYO UNIV., DPT OF MEDICINE, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (80240703)

Co-Investigator(Kenkyū-buntansha) FUJIE Hajime  TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
SHINTANI Yoshizumi  TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
MORIYA Kyoji  TOKYO UNIV., DPT OF MEDICINE, ASSISTANT PROFESSOR, 医学部・附属病院, 助手
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 1999: ¥5,000,000 (Direct Cost: ¥5,000,000)
Keywordshepatitis C virus / transgenic mice / core protein / hepatocellular carcinoma / hepatitis / steatosis / コア蛋白
Research Abstract

Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide, which finally leads to the development of hepatocellular carcinoma (HCC). However, the mechanism of hepatocarcinogenesis in chronic HCV infection is still unclear. The ability of the core protein of HCV to modulate intracellular signaling pathways has been suggested as being involved in the pathogenesis of HCC.Here we describe the development of HCC in HCV core gene transgenic mice which develop hepatic steatosis early in life as a histological feature characteristic of chronic hepatitis C.The feature in the development of HCC in these mice closely resembled the histopathological characteristics previously observed in the early stage of HCC in patients with chronic hepatitis C.These results indicate that the HCV core protein has a major role in the development of HCC and that HCV itself is directly involved in hepatocarcinogenesis.

Report

(2 results)
  • 2000 Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (19 results)

All Other

All Publications (19 results)

  • [Publications] K.Moriya et al.: "Hepatitis C virus Core protein induces hopatocellular carcinoma in trangenic mice"Nat Med. 4. 1065-1068 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Fujie et al.: "Steatosis and intratepatic hepatitis C virus in chronic hepatitis"J Med Virol. 59. 141-145 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Shintani et al.: "Induction of apoptosis after the switch-on of the hepatitis B virus X gene medioctal by Crell ox P recombinase system"J Gem Virol. 80. 3257-3266 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Koike et al.: "Survey of hepatitis B virus co-infection in Lepatitis C virus-infected patients suffering from chronic hepatitis and hypotocellula caratmo in Japan"Jpn J Cancer Res. 90. 1270-1272 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Koike: "Travsgenic mouse model of viral hapatitis : Insight into viral hepato carciaogenesis"Viral Hepatitis Rev. 5(in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Yotsuyanagi et al.: "Virological analysis of "non-B, non-C" hepatocellular carcioma in Japan"J Infect Dis. 181(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Moriya, H.Fujie, Y.Shintani, H.Yotsuyanagi, T.Tsutsumi, Y.Matsuura, S.Kimura, T.Miyamura, K.Koike.: "Hepatitis C virus core protein induces hepatocellular carcinoma in transgenic mice."Nature Med.. 4. 1065-1068 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Fujie, H.Yotsuyanagi, K.Moriya, Y.Shintani, T.Tsutsumi, T.Takayama, M.Makuuchi, Y.Matsuura, T.Miyamura, S.Kimura, K.Koike.: "Steatosis and Intrahepatic hepatitis C virus in chronic hepatitis."J Med Virol. 59. 141-145 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Shintani, H.Yotsuyanagi, K.Moriya, H.Fujie, T.Tsusumi, Y.Kanegae, S.Kimura, I.Saito, K.Koike.: "Induction of apoptosis after the switch-on of the hepatitis B virus X gene mediated by Cre/loxP recombinase system."J Gen Virol. 80. 3257-3266 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Koike, K.Shimotohno, S.Okada, H.Okamoto, N.Hayashi, K.Ueda, S.Kaneko, K.Koike, O.Yokosuka, et al.: "Survey of hepatitis B virus co-infection in hepatitis C virus-infected patients suffering from chronic hepatitis and hepatocellular carcinoma in Japan."Jpn J Cancer Res. 90. 1270-1272 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K.Koike: "Transgenic mouse models of viral hepatitis : Insight into viral hepatocarcinogenesis."Viral Hepatitis Rev.. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] H.Yotsuyanagi, Y.Shintani, K.Moriya, H.Fujie, T.Tsutsumi, T.Kato, K.Nishioka, T.Takayama, M.Makuuchi, S.Iino, S.Kimura, K.Koike.: "Virological analysis of "non-B, non-C" hepatocellular carcinoma in Japan : frequent involvement of hepatitis B virus.."J Infect Dis. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Y.Shintani, H.Yotsuyanagi, K.Moriya, H.Fujie, T.Tsutsumi, T.Takayama, M.Makuuchi, S.Kimura, K.Koike.: "Significance of hepatitis B virus DNA detected in hepatocellular carcinoma in patients with hepatitis C."Cancer. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] K. Moriya et al.: "Hepatitis C virus core protein induces hepato cellular carcinoma in trangenic mice"Nat. Med.. 4. 1065-1068 (1988)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Fujie et al.: "Steatosis and intrahepatic hepatitis C virus in chronic hepatitis"J. Med. Virol.. 59. 141-145 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y. Shintani et al.: "Induction of apoptosis after the switch-on of the hepatitis B virus X gene mediated by Cre/Lox P recombinase system"J. Gen. Virol.. 80. 3257-3266 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Koike et al.: "Survey of hepatitis B virus co-infection in heptitis C virus-infected patients suffering from chronc hepatocellular carcinoma in Japan"Jpn J Cancer Res.. 90. 1270-1272 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K. Koike et al.: "Transgenic mouse model of viral hepatitis: Insight into viral hepatocarcinogenesis"Viral Hepatitis Rev.. 5 (in press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] H. Yotsuyanagi et al.: "Virological anaysis of "non-B, non-C" hepaatocellular carcinoma in Japan"J. Infect. Dis.. 181. in press (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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