| Project/Area Number |
11167210
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KATAOKA Kazunori Graduate School of Engineering, Department of Mterials Science and Engineering, Professor, 大学院・工学系研究科, 教授 (00130245)
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| Co-Investigator(Kenkyū-buntansha) |
原田 敦史 東京大学, 大学院・工学系研究科, 助手 (50302774)
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| Project Period (FY) |
1998 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥49,500,000 (Direct Cost: ¥49,500,000)
Fiscal Year 2002: ¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2001: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2000: ¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 1999: ¥9,900,000 (Direct Cost: ¥9,900,000)
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| Keywords | Molecular Synchronization / Materials sysytem / Chemical valva / Nano-associate / Pancreatic beta cell / Insulin / Drug delivery device / Gene therapy / ケミカルバルブ / フェニルボロン酸 / グルコース / ブロック共重合体 / ポリエチレングリコール / ドラッグデリバリー |
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| Research Abstract |
The objective of this study is to construct chemical-valve system based on the concept of molecular synchronization. For this purpose, two-types of materials systems were examined here : (1)Networked structure of polymers (polymeric gels) and (2)nano-associates of block copolymers (polymeric micelles). The former system was focused on the development of materials undergoing abrupt change in their volume at physiological condition responding to external glucose concentration. A basis of the system studied here is the shift in the equilibrium between the uncharged and charged form of phenylboronic acid moieties in the polymer chain thorough complex formation with glucose. An increased glucose-concentration shifts the equilibrium in the direction of increasing fraction of borate anions and decreasing the fraction of the uncharged form. Charged borates are certainly more hydrophilic than the uncharged form. Thus, a glucose-dependent change in the ratio between uncharged and charged borates in the polymer chain should crucially affect the polymer solubility, if the polymer chain has an amphiphilic character. Apparently, this materials system should be useful to construct self-regulating insulin-releasing device for the treatment of diabetes. The latter system was designed to dissociate upon its internalization into the intracellular compartment so as to release cargo compounds selectively inside of target cells. These stimuli-sensitive polymeric micelles should be useful as nanocanrriers for gene and drug delivery.
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