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がんの生物学的特性に関する研究の総括

Research Project

Project/Area Number 11179101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

高井 義美  大阪大学, 医学系研究科, 教授 (60093514)

Co-Investigator(Kenkyū-buntansha) 金倉 譲  大阪大学, 医学系研究科, 教授 (20177489)
秋山 徹  東京大学, 分子細胞生物学研究所, 教授 (70150745)
清木 元治  東京大学, 医科学研究所, 教授 (10154634)
渋谷 正史  東京大学, 医科学研究所, 教授 (10107427)
平井 久丸  東京大学, 医学部附属病院, 助教授 (90181130)
谷口 維紹 (谷口 継紹)  東京大学, 医科学研究科, 教授 (50133616)
Project Period (FY) 1999 – 2004
Project Status Completed (Fiscal Year 2004)
Budget Amount *help
¥62,700,000 (Direct Cost: ¥62,700,000)
Fiscal Year 2004: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 2003: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2002: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2001: ¥15,000,000 (Direct Cost: ¥15,000,000)
Fiscal Year 2000: ¥13,000,000 (Direct Cost: ¥13,000,000)
Fiscal Year 1999: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywordsがん / 増殖因子 / シグナル伝達 / 分化 / 細胞死 / 細胞周期 / 浸潤・転移 / 細胞外マトリックス
Research Abstract

本領域は「がん研究の総合的推進に関する研究」の一環として、がんの生物学的研究を担うものである。すなわち、がんの生物学的特性を明らかにすることによって、がんの予防、診断、治療に貢献することを目的とする。本年度の総括班における成果を以下に列記する。
1.がんの生物学的研究の分野において未解決の重要な問題を解明するために、総括班は以下の5項目について研究を計画した。A01:がん細胞の増殖応答の異常の研究、A02:がんの形成過程における細胞の分化と死の研究、A03:がん細胞の制御異常とがん形質の研究、A04:がん細胞の浸潤と転移の研究、A06:組織形成異常とがんとの関連の研究。
2.領域代表者である高井義美をA01の分野長とし、以下、A02 金倉 譲、A03 秋山 徹、A04 清木元治、A05 渋谷正史とした。
3.研究を推進するために、重要かつ緊急性のあるテーマと優れた研究者を計画的に支援する目的で、総計40の研究計画を設定し、その研究内容の評価を行った。また、公募により自由な発想に基づく研究を募集し、その研究内容を評価した。評価はおおむね良く、着実に成果が出ているとのことであった。
4.総括班会議および分野長会議を開催し、上記重要課題につき検討した上で方針を決定し、領域の円滑な運営を進めた。また、計画研究代表者が、研究成果・今後の研究方針・今後のがんの生物学的研究のあり方について議論を行った。
今年度は本研究の最終年度にあたるが、「がんの生物学的特性を明らかにすることによって、がんの予防、診断、治療に貢献する」という本研究の最終目的をほぼ達成できたと判断している。

Report

(6 results)
  • 2004 Annual Research Report
  • 2003 Annual Research Report
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (105 results)

All 2005 2004 Other

All Journal Article (10 results) Publications (95 results)

  • [Journal Article] Membrane-type matrix metalloproteinase-1 (MT1-MMP) is a processing enzyme for human laminin gamma 2 chain.2005

    • Author(s)
      Koshikawa, N.
    • Journal Title

      J Biol.Chem. 280・1

      Pages: 88-93

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Enhancement of serum and platelet-derived growth factor-induced cell proliferation by Necl-5/Tage4/Poliovirus Receptor/CD155 through the Ras-Raf-MEK-ERK signaling.2004

    • Author(s)
      Kakunaga, S.
    • Journal Title

      J.Biol.Chem. 279・17

      Pages: 18015-18025

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG.2004

    • Author(s)
      Fukuhara, T.
    • Journal Title

      J.Cell Biol. 166・3

      Pages: 393-405

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of a cytokine-induced anti-apoptotic molecule Anamorsin essential for definitive hematopoiesis.2004

    • Author(s)
      Shibayama, H.
    • Journal Title

      J.Exp.Med. 199・4

      Pages: 581-592

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Roles of c-myc in self-renewal of hematopoietic stem cells.2004

    • Author(s)
      Satoh, Y.
    • Journal Title

      J.Biol.Chem. 279・24

      Pages: 24986-24993

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Identification of BMP and Activin Membrane-bound Inhibitor (BAMBI), an Inhibitor of Transforming Growth Factor-β Signaling, as a Target of the P-Catenin Pathway in Colorectal Tumor Cells.2004

    • Author(s)
      Sekiya, T.
    • Journal Title

      J.Biol.Chem. 279・8

      Pages: 6840-6846

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Anteriorization of neural fate by ICAT, a negative regulator of Wnt signaling.2004

    • Author(s)
      Satoh, K.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101・21

      Pages: 8017-8021

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase.2004

    • Author(s)
      Nakamura, H.
    • Journal Title

      Cancer Res. 64・3

      Pages: 876-882

    • Related Report
      2004 Annual Research Report
  • [Journal Article] A Novel Snake Venom Vascular Endothelial Growth Factor (VEGF) Predominantly Induces Vascular Permeability through Preferential Signaling via VEGF Receptor-1.2004

    • Author(s)
      Takahashi, H.
    • Journal Title

      J.Biol.Chem. 279・44

      Pages: 46304-46314

    • Related Report
      2004 Annual Research Report
  • [Journal Article] Tyrosine phosphorylation sites on FRS2a responsible for Shp2 recruitment are critical for induction of lens and retina.2004

    • Author(s)
      Gotoh, N.
    • Journal Title

      Proc.Natl.Acad.Sci.USA 101・49

      Pages: 17144-17149

    • Related Report
      2004 Annual Research Report
  • [Publications] Ikeda, W.: "Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration."J.Biol.Chem.. 278・30. 28167-28172 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Fukuhara. A.: "Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells."J.Biol.Chem.. 278・51. 51885-51893 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Ikeda, W.: "Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, nectin-3-independent manner."J.Biol.Chem.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Shibayama, H.: "Identification of a cytokine-induced anti-apoptotic molecule Anamorsin essential for definitive hematopoiesis."J.Exp.Med.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawasaki, A.: "Opposing effects of PML and PML/RARα on STAT3 activities."Blood. 101・9. 3668-3673 (2002)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kataoka, Y.: "Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts."J.Biol.Chem.. 278・45. 44178-44187 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells."Nature Cell Biology. 5・3. 211-215 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Okabe, T.: "RICS, a novel GTPase-Activating Protein for Cdc42 and Rac1,is involved in the b-catenin-N-cadherin and NMDA receptor signaling."J.Biol.Chem.. 278・11. 9920-9927 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Sekiya, T.: "Identification of BAMBI, an inhibitor of TGF-b signaling, as a target of the b-catenin pathway in colorectal tumor cells."J Biol Chem.. 279・8. 6840-6846 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Uekita, T.: "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) is a new member of the Cupin superfamily : A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors."J Biol Chem.. in press. (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuki, H.: "Monoclonal antibodies with defined recognition sequences in the stem region of CD44 : detection of differential glycosylation of CD44 between tumor and stromal cells in tissue."Cancer Res.. 63. 8278-8283 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Matsuda, A.: "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils."J Biol Chem.. 278・38. 36350-36357 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kiyono, M.: "Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression."Mol.Cell.Biol.. 23・13. 4627-4636 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Autiero, M.: "Role of PIGF in the intra- and inter-molecular crolltalk between VEGF receptors Flt1 and Flk1."Nature Med.. 9・7. 936-943 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Saito, M.: "Tubular Formation by Angiopoietin-1 in Endothelial Cell/Fibroblast Co-culture is Dependent on Endogenous VEGF."Cancer Science. 94・9. 782-790 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Kawakatsu, T.: "Trans-interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins"J. Biol. Chem.. 277・52. 50749-50755 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takekuni, K.: "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse"J. Biol. Chem.. 278・8. 5497-5500 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Izutsu, K.: "The t(3;21) fusion product, AML1/Evi-1, blocks AML1-induced transactivation by recruiting CtBP"Oncogene. 21・17. 2695-2703 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Suzuki, T.: "MICAL, a novel CasL interacting molecule, associates with vimentin"J. Biol. Chem.. 277・17. 14933-14941 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells"Nature Cell Biology. 5・3. 211-215 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Jimbo, T.: "Identification of link between the tumor suppressor APC and the kinesin superfamily of protein"Nature Cell Biology. 4・4. 323-327 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Mori, H.: "CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain"EMBO J.. 21・15. 3949-3959 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Seiki, M.: "The cell surface : the stage for matrix metalloproteinase regulation of migration"Curr. Opin. Cell Biol.. 14・5. 624-632 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiratsuka, S.: "MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 is involved in lung secific metastasis"Cancer Cell. 2・4. 289-300 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kiba, A.: "A set of loop-1 and -3 structures in the novel VEGF family member, VEGF-E_<NZ-7>, is essential for the activation of VEGFR-2 signaling"J. Biol. Chem.. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takayanagi, H.: "RANKL maintains bone homeostasis through c-Fos-dependent induction of IFN-β"Nature. 416・6882. 744-749 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takayanagi, H.: "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts"Dev Cell. 3・6. 889-901 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakayama, K.: "A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3"EMBO J.. 21・22. 6174-6184 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Matsui, T.: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J.. 21・5. 1021-1030 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Furuse, M.: "Claudin-based tight junctions are crucial for the mammalian epidermal barrier : A lesson from claudin-1-deficient mice"J. Cell Biol.. 156・6. 1099-1111 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kikuchi, S.: "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes"Nat. Genet.. 31・3. 320-325 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hanafusa, H.: "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway"Nature Cell Biol.. 4・11. 850-858 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Yamanaka, H.: "JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates"EMBO Rep.. 3・1. 69-75 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Nakanishi, K.: "Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer"Cancer Res.. 62・10. 2971-2975 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Sekine, S.: "Target disruption of the mutant β-catenin gene in colon cancer cell line HCT116 : preservation of its malignant phenotype"Oncogene. 21・38. 5906-5911 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shinohara, M.: "Roles of cell-cell adhesion-dependent tyrosine phosphorylation of Gab-1"J. Biol. Chem.. 276・22. 18941-18946 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yokoyama, S.: "α-Catenin-independent recruitment of ZO-1 to nectin-based cell-cell adhesion sites through afadin"Mol. Biol. Cell. 12・6. 1595-1609 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu, K.: "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain"EMBO J.. 21・3. 294-302 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu, K.: "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation"J. Biol. Chem.. 276・28. 25753-25758 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Jimbo, T.: "Link between the Tumor Suppressor APC and the Kinesin Superfamily of Proteins"Nature Cell Biol.. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kohu, K.: "The SH3, HOOK and Guanylate Kinase-like Domains of hDLG are Important for its Cytoplasmic Localization"Genes Cells. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Itoh, Y.: "Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion"EMBO J.. 20・17. 4782-4793 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kajita, M.: "Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration"J. Cell. Biol.. 153・5. 893-904 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi, T.: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells"EMBO J.. 20・11. 2768-2778 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hiratsuka, S.: "Involvement of Flt-1 tyrosine kinase (Vascular endothelial growth factor receptor-1) in pathological angiogenesis"Cancer Res.. 61・3. 1207-1213 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sato, K.: "Antiviral response by natural killer cells through TRAIL gene induction by IFN-α/β"Eur. J. Immunol.. 31・11. 3138-3146 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hata, N.: "Constitutive IFN-α/β signal for efficient IFN-α/β gene induction by virus"Biochem. Biophys. Res. Commun.. 285・2. 518-515 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsui, T.: "K-Ras mediates cytokine-induced formations of E-cadherin-based adherens junctions during liver development"EMBO J.. 21・5. 1021-1030 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takeuchi, M.: "Cultivation of AGM-derived hematopoietic stem cells in the fetal liver microenvironment amplifies long-term repopulating activity and enhances engraftment to the bone marrow"Blood. 99・4. 1190-1196 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Itoh, M.: "Junctional adhesion molecule (JAM) binds to PAR-3 : a possible mechanism for the recruitment of PAR-3 to tight junctions"J. Cell Biol.. 154・3. 491-497 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Furuse, M.: "Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into MDCK I cells"J. Cell Biol.. 153・2. 263-272 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toyoshima-Morimoto, F.: "Plk1 promotes nuclear translocation of human Cdc25C during prophase"EMBO Reports. (in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamanaka, H.: "JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates"EMBO Reports. 3・1. 69-75 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ino, Y.: "Dysadherin, a cancer-associated cell membrane glycoprotein, down-regulates E-cadherin and promotes metastasis"Proc. Natl. Acad. Sci. USA. 99・1. 365-370 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Naishiro, Y.: "Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of β-catenin/T-cell factor 4-mediated gene transactivation"Cancer Res.. 61・6. 2751-2758 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tachibana,K.: "Two cell adhesion molecules, Nectin and Cadherin interact through their cytoplasmic domain-associated proteins."J.Cell Biol.. 150・5. 1161-1176 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kodama,A.: "Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering."Mol.Biol.Cell. 11・8. 2565-2575 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kurokawa,M.: "The Evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."EMBO J.. 19・12. 2958-2968 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yamagata,T.: "Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs."EMBO J.. 19・17. 4676-4687 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kawasaki,Y.: "Asef, a Link between the Tumor Suppressor APC and G-protein Signaling."Science. 289・5482. 1194-1197 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tago,K.: "Inhibition of Wnt signaling by ICAT, a Novel β-catenin-interacting Protein."Gense Dev.. 14・14. 1741-1749 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kojima,S.: "Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP."FEBS Lett.. 480・2-3. 142-146 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kim,K.R.: "Transformation of Madin-Darby canine kidney (MDCK) epithelial cells by Epstein-Barr virus latent membrane protein 1 (LMP1) induces expression of Etsl and invasive growth."Oncogene. 19・14. 1764-1771 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sawano,A.: "Vascular Endothelial Growth Factor Receptor-1. (Flt-1) is a Novel Cell Surface Marker for the Lineage of Monocyte-Macrophages in Humans."Blood. 97・3. 785-791 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Maru,Y.: "An oncogenic form of the Flt-1 kinase has a tubulogenic potential in a sinusoidal endothelial cell line."J.Cell Biol.. 79・2. 130-143 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takaoka,A.: "Crosstalk between interferon-γ and-α/β signaling components at caveolar membrane domain."Science. 288・5475. 2357-2360 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takayanagi,H.: "T-cell-mediated regulation of osteocrastogenesis by signalling cross-talk between RANKL and IFN-γ."Nature. 408・6812. 600-605 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ito Y.: "Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and Ras pathways during hepatic development."Hepatology. 32・6. 1370-1376 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kojima N.: "Cell-density-dependent regulation of hepatic development by a gp130-independent pathway."Biochem.Biophys.Res.Commun.. 277・1. 152-158 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tsukita,Sh.: "Pores in the wall : Claudins constitute tight junction strands containing aqueous pares."J.Cell Biol.. 149・1. 13-16 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Sitou,M.: "Complex phenotype of mice lacking occludin, a component of tight junction strands."Mol.Cell Biol.. 11・12. 4131-4142 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Toyoshima-Morimoto,F.: "Pole-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase."Nature. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Harada,T.: "ERK induces p35, the neuron-specific activator of cdk5 essential for neurite outgrowth, through the induction of Egr1."Nature Cell Biol.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ishii,Y.: "Integrin α6β4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer."Gastroenterology. 118・3. 497-506 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Genda,T.: "Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells."Laboratory Investigation. 80・3. 387-394 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Umikawa, M.: "Association of frabin with the actin cytoskeleton is essential for microspike formation through activation of Cdc42 small G protein"J. Biol. Chem.. 274・36. 25197-25200 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ikeda, W.: "Afadin : A key molecule essential for structural organization of cell-cell junctions of polarised epithelia during embryogenesis"J. Cell. Biol.. 146・5. 1117-1132 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu, K.: "Mouse jagged1 physically interacts with notch2 and other notch receptors : Assessment by quantitative methods"J. Biol. Chem.. 274・46. 32961-32969 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakamoto, T.: "CIZ : a zinc finger protein that interacts with p130cas and activates the expression of matrix metalloproteinases"Mol. Cell. Biol.. 20・5. 1649-1658 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hamada, F.: "Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin"Science. 283・5408. 1739-1742 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishidate, T.: "The APC-hDLG complex negatively regulates cell cycle progression from the G0/G1 to S phase"Oncogene. 19・3. 365-372 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] Itoh, Y.: "Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a qlycosylphosphatidylinositol-anchored proteinase"J. Biol. Chem.. 274・48. 34260-34266 (1999)

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  • [Publications] Kajita, M.: "Human membrane type-4 matrix metalloproteinase (MT4-MMP) is encoded by a novel major transcript : isolation of complementary DNA clones for human and mouse mt4-mmp transcripts [In Process Citation]"FEBS Lett.. 457・3. 353-356 (1999)

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      1999 Annual Research Report
  • [Publications] Shibuya, M.: "Structure and function of vascular endothelial growth factor receptor-1 and -2"Curr. Top. Microbiol. Immunol.. 237. 59-83 (1999)

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      1999 Annual Research Report
  • [Publications] Takahashi, T.: "VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells"Oncogene. 18・13. 2221-2230 (1999)

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      1999 Annual Research Report
  • [Publications] Takaoka, A.: "Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in the IFN-γ, but not IFN-α, signaling"EMBO J.. 18・9. 2480-2488 (1999)

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      1999 Annual Research Report
  • [Publications] Nozawa, H.: "Loss of transcription factor IRF-1 affects tumor susceptibility in mice carrying the Ha-ras transgene or nullizygosity for p53"Genes Dev.. 13・10. 1240-1245 (1999)

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      1999 Annual Research Report
  • [Publications] Kamiya, A.: "Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer"EMBO J.. 18・8. 2127-2136 (1999)

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      1999 Annual Research Report
  • [Publications] Hara, T.: "Identification of podocalyxin-like protein 1 as a novel cell surface marker for hemangioblasts in the murine aorta-gonad-mesonephros region"Immunity. 11・5. 567-578 (1999)

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      1999 Annual Research Report
  • [Publications] Morita, K.: "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands"Proc. Natl. Acad. Sci. USA. 96・2. 511-516 (1999)

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      1999 Annual Research Report
  • [Publications] Morita, K.: "Claudin-11/OSP-based tight junctions in myelin sheaths in brain and Sertoli cells in testis"J. Cell Biol.. 145・3. 579-588 (1999)

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      1999 Annual Research Report
  • [Publications] Akashi, M.: "Involvement of the MAP kinase cascade in resetting of the mammalian circadian clock"Genes Dev.. (in press). (2000)

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      1999 Annual Research Report
  • [Publications] Tanoue, T.: "A conserved docking motif in MAP kinases common to substrates, activators and regulators"Nat. Cell Biol.. 2・2. 110-116 (2000)

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      1999 Annual Research Report
  • [Publications] Ono, Y.: "Clinicopathologic significance of laminin-5 γ2 chain expression in squamous cell carcinoma of the tongue : immunohistochemical analysis of 67 lesions"Cancer. 85・11. 2315-2321 (1999)

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      1999 Annual Research Report
  • [Publications] Genda, T.: "Cell motility mediated by Rho and Rho-associated protein kinase plays a critical role in intrahepatic metastasis of human hepatocellular carcinoma"Hepatology. 30・4. 1027-1036 (1999)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2018-03-28  

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