神経回路の成熟と特異的機能発現のメカニズム

• Project/Area Number: 11183101
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kyoto University
• Principal Investigator: 大森 治紀 京都大学, 医学研究科, 教授 (30126015)
• Co-Investigator(Kenkyū-buntansha): 澁木 克栄 (渋木 克栄) 新潟大学, 脳研究所, 教授 (40146163) ; 野田 亮 京都大学, 医学研究科, 教授 (30146708) ; 山森 哲雄 自然科学研究機構, 基礎生物学研究所, 教授 (80260206) ; 白尾 智明 群馬大学, 医学部, 教授 (20171043) ; 中西 重忠 京都大学, 生命科学研究科, 教授 (20089105) ; 堀田 凱樹 国立遺伝学研究所, 所長 (30010036)
• Project Period (FY): 1999 – 2004
• Project Status: Completed (Fiscal Year 2004)
• Budget Amount: ¥43,800,000 (Direct Cost: ¥43,800,000); Fiscal Year 2004: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2003: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2002: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2001: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 2000: ¥8,000,000 (Direct Cost: ¥8,000,000); Fiscal Year 1999: ¥3,800,000 (Direct Cost: ¥3,800,000)
• Keywords: 神経回路 / シナプス / 特徴抽出 / 回路調節 / 回路形成 / 行動制御 / 分子の探求 / 分子の探究 / 機能発現 / 神経回路形成

Research Abstract

神経回路の成熟と特異的機能発現のメカニズム(略称「神経回路」)総括班では、6年間の特定領域研究を締めくくる研究班会議を京都で開催した(平成17年1月26-28日)。現在の研究班員83名全員が発表した。各班員の研究成果は、班友および平成12年度以降、一時的に研究班に参加した公募研究者も含めて冊子体の研究成果報告書にまとめた。なお、こうした班員の多くが班会議には参加し、活発な討論が行われた。
総括班会議を、同班会議の終了後開催した。4名の評価委員が総括班会議に参加し、様々な角度から、神経回路研究の現状と将来展望を討議した。神経回路は神経科学の中でも、分子的なアプローチと、高次脳機能に象徴されるシステム的なアプローチの両方の研究を展開することのできる場であることを、改めて認識し、将来ともに活発な研究を展開できる研究領域であるとの評価を得た。
総括班では、神経回路という特定領域研究を過去5年間に亘って進めるに際しては、この領域を単に研究費を配分するだけの役割に留めず、班員相互間の良いコミュニケーションに支えられた研究者のフォーラムとすることを目的としてきた。今回、研究班会議を開催し、さらに研究報告書をまとめるに際して、非常に多くの共同研究が行われていることが明らかとなった。また、こうした共同研究が研究領域内に留まらず、さらに多くの共同研究が研究領域外の研究者との間で行われていることも明らかとなった。こうした意味においても、本特定領域研究は、実質5年間の研究期間内に十分な社会的役割を果たし得たものと確信することができた。

Research Products

• [Journal Article] Tonotopic specialization of auditory coincidence detection in nucleus laminaris of the chick (2005)
  • Author(s): Hiroshi Kuba, Rei Yamada, Iwao Fukui, Harunori Ohmori
  • Journal Title: Journal of Neuroscience 25(8) Pages: 1924-1934
• [Journal Article] Drebrin A is a Postsynaptic Protein that Localizes in vivo to the Submembranous Surface of Dendritic Sites Forming Excitatory Synapses (2005)
  • Author(s): Aoki, C.(5名略), Shirao, T
  • Journal Title: J.Comp.Neurol. 483(4) Pages: 383-402
• [Journal Article] Tonotopic Gradients of membrane and synaptic properties for neurons of the chicken nucleus magnocellularis (2004)
  • Author(s): Iwao Fukui, Harunori Ohmori
  • Journal Title: Journal of Neuroscience 24(34) Pages: 7514-7523
• [Journal Article] Short-term plasticity visualized with flavoprotein autofluorescence in the somatosensory cortex of anesthetized rats (2004)
  • Author(s): Murakami H, (4名略) Kawaguchi T, Tanaka R, Shibuki K
  • Journal Title: European.J.Neuroscice. 19 Pages: 1352-1360
• [Journal Article] Effects of Rap1 and Ras on voltage-gated sodium current in cultured neuronal cells. (2004)
  • Author(s): Y.Imamura, Matsumoto N, Kondo S, Kitayama H, Noda M
  • Journal Title: Neuroscience 127 Pages: 973-981
• [Journal Article] Behavioral studies of auditory-visual spatial recognition and integration in rats (2004)
  • Author(s): Sakata S, Yamamori T, Sakurai Y
  • Journal Title: Experimental Brain Research 159(4) Pages: 409-417
• [Publications] Fukui I, Ohmori H: "Developmental changes in membrane excitability of neurons in the nucleus angularis of the chicken"Journal of Physiology. 548.1. 219-232 (2003)
• [Publications] Suga K, Yamamori T, Akagawa K: "Identification of the carboxyl-terminal membrane anchoring region of HPC-1/Syntaxin 1A with substituted-cysteine^accessibility"Journal of Biochemistry. 133. 325-334 (2003)
• [Publications] Ihara M, et al.: "Association of the cytoskeletal GTP-binding protein Sept4/H5 with cytoplasmic inclusions found in Parkinson's disease and other"Journal of Biological Chemistry. 278. 24095-24102 (2003)
• [Publications] Takahashi H, Sekino Y, Tanaka S, Mizui T, Kishi S, Shirao T: "Drebrin-dependent actin clustering in dendritic filopodia governs synaptic targeting of postsynaptic density-95 and dendritic spine morphogenesis"Journal of Neuroscience. 23(16). 6586-6595 (2003)
• [Publications] 大森治紀, 澁木克栄, 野田亮, 山森哲雄: "神経回路の機能発現のメカニズム"共立出版. 500 (2004)
• [Publications] Kuba H, Koyano K, Ohmori H: "Development of membrane conductance improves coincidence detection in the nucleus laminaris of the chicken"Journal of Physiology. 540.2. 529-542 (2002)
• [Publications] Kudoh M, Sakai M, Shibuki K: "Differential dependence of LTD on glutamate receptors in the auditory cortical synapses of cortical and thalamic inputs"Journal of Neurophysiology. 88.6. 3167-3174 (2002)
• [Publications] Oh J, (18名略) M.Noda: "The membrane anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis"Cell. 107. 789-800 (2001)
• [Publications] Sakata S, (2名略), Yamamori T, Sakurai Y: "Task dependent and cell type specific fos enhancement in rat sensory cortices during audio-visual discrimination"European Journal of Neuroscience. 15. 735-743 (2002)
• [Publications] Jin M, Tanaka S, Shirao T他5名: "A novel brain specific mouse drebrin : cDNA clonig, chromosomalmapping, genomic structure, expression and functional characterization"Genomics. 79. 686-692 (2002)
• [Publications] Takahiro M Ishii, Makoto Takano, Harunori Ohmori: "Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels"Journal of Physiology. 537. 93-100 (2001)
• [Publications] Nao Chuhma, H. Ohmori: "Role of Ca2+ in the synchronization of transmitter release at calyceal synapse in the auditory system of rat"Journal of Neurophysiology. 87. 222-228 (2002)
• [Publications] Seki K., Kudoh M., Shibuki K.: "Sequence dependence of post-tetanic potentiation after sequential heterosynaptic stimulation in the rat auditory cortex"J. Physiol.. 533. 503-518 (2001)
• [Publications] Watakabe A, Fujita H, Hayashi M, Yamamori T.: "Growth/differentiation factor 7 is preferentially expressed in the primary motor area of the monkey neocortex"J. Neurochem. 76. 1455-1464 (2001)
• [Publications] Oh J, Takahashi R, Kondo S, Mizoguchi A, Adachi E, Sasahara RM, Nishimura S, Imamura Y, Kitayama H, Alexander DB, Ide C, et al.: "The membrane-anchored MMP inhibitor RECK is a key regulator of extracelluar matrix integrity and anglogenesis"Cell. 14. 789-800 (2001)
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• [Publications] Chuhma,N,Koyano,K & Ohmori,H: "Synchronisation of Neurotransmitter Release during Postnatal Development in a Calyceal Presynaptic Terminal."Journal of PHysiology. 530.1. 93-104 (2001)
• [Publications] Kimura,S.,Uchiyamama,S.,Takahashi,H.E.and Shibuki,K.: "Cyclic AMP-dependent long-term potentiation of nitric oxide release from cerebellar parallel fibers in rats."Journal of Neuroscience. 18. 8551-8558 (1998)
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• [Publications] Masaki Hiramoto,Yasushi Hiromi and Yoshiki Hotta: "The Drosophila Netrin receptor Frazzled, guides axons by controlling Netrin distribution."Nature. 406. 886-889 (2000)
• [Publications] Kaneko,S.,Hikida,T.,Watanabe,D.,Ichinose,H., et al: "Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function."Science. 289. 633-637 (2000)
• [Publications] Ishii, M. T. et al.: "Molecular characterization of the hyperpolarization-activated cation channel in rabbit heart sinoatriol node"J. Biol. Chem.. 274. 12835-12839 (1999)
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