| Project/Area Number |
11217210
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KIMURA Yoshiharu Kyoto Institute of Technology, Polymer Science and Engineering, Professor, 繊維学部, 教授 (10132276)
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| Co-Investigator(Kenkyū-buntansha) |
TANIGUCHI Ikuo Kyoto Institute of Technology, Polymer Science and Engineering, Research associate, 繊維学部, 助手 (30314305)
MIYAMOTO Masatoshi Kyoto Institute of Technology, Polymer Science and Engineering, Associate professor, 繊維学部, 助教授 (70149524)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥48,600,000 (Direct Cost: ¥48,600,000)
Fiscal Year 2002: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 2001: ¥9,900,000 (Direct Cost: ¥9,900,000)
Fiscal Year 2000: ¥11,700,000 (Direct Cost: ¥11,700,000)
Fiscal Year 1999: ¥16,500,000 (Direct Cost: ¥16,500,000)
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| Keywords | Biodegradable polyester / life-controlled degradability / Crystallinity / Copolymerization / Molecular and material design / polylactide / poly (butylenes succinate) / poly (3-hydroxybutyrate) / 生分解性ポリマー / 脂肪族ポリエステル / 芳香族・脂肪族コポリエステル / 分解機構 / 化学合成 / ブロックポリマー / 12-ヒドロキシステアリン酸 / ゾル-ゲル転移 / β-ブチロラクトン / 結晶核剤 / 時限分解 / 結晶刻剤 |
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| Research Abstract |
Various aliphatic polyesters have been synthyesized as biodegradable polymers thus far. Their biodegradability has been known to depend largely on the crystallinity as well as on the crystal size and morphology. In this research, various biodegradable polyesters having life-controlled degradability are designed and synthesized by ring-opening polymerization of new monomers and by well-controlled direct polycondensation.
For example, glycolate and malate units were introduced into poly (3-hydroxybutyric acid) (PHB) to enhace the hydrolyzability of PHB and to have wide options for the functionalization of PHB. 12-Hydroxystearic acid (12HSA unti was also incorporated into poly (L-lactic acid) (PLLA) by ring-opening copolymerization of L-lactide and cyclic dimer of 12HSA in order to attain a soft PLLA derivative. Copolymerization of L-lactic acid with mandelic acid was also conducted to obtain glassy biodegradable copolymer with high glass transition temperature and increase degradability.
… More
Block copolymers of PLLA and poly (oxyethylene) (PEG) were prepared by the ring-opening copolymerization of PEG and L-lactide and dispersed into water to obtain core-shell nanoparticles. From these particles, a specific band structure was formed by the crystallization of the helical PLLA blocks. Sol-gel transition was found to occur on mixing the disperisions of the enationmeric A-B-A triblock copolymers, PLLA-PEG-PLLA and PDLA-PEG-PDLA. This transition was driven by the stereo-complexation of the PLLA and PDLA chains. The core-sheath bicomponent fiber consisting of poly (glycolic acid) (PGA) and PLLA as the core and sheath, respectively, was processed by melt-spinning. The fiber showed higher degradability than the single PLLA fiber.
Enzymatic degradation of poly (butylene succinate) (PBS) and its derivative, poly (butylene succinate-co-terephthalate) (PBST) was studied by using a lipase originated from Pseudomonas cepacia. PBS and PBST was biodegraded by exo-type and endo-type scission of ester linkage, respectively. Less
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