| Project/Area Number |
11217211
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Hiroshima University |
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Principal Investigator |
SHIRAHAMA Hiroyuki Hiroshima University, Center for Technology Research and Development, Associate Professor, 地域共同研究センター, 助教授 (60127660)
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| Co-Investigator(Kenkyū-buntansha) |
TAMAI Hisashi Hiroshima University, Graduate School of Engineering, Associate Professor, 大学院・工学研究科, 助教授 (40106802)
YASUDA Hajime Hiroshima University, Graduate School of Engineering, Professor, 大学院・工学研究科, 教授 (00028200)
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| Project Period (FY) |
1999 – 2002
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| Project Status |
Completed (Fiscal Year 2002)
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| Budget Amount *help |
¥15,600,000 (Direct Cost: ¥15,600,000)
Fiscal Year 2002: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2001: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 2000: ¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1999: ¥4,900,000 (Direct Cost: ¥4,900,000)
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| Keywords | Biodegradable polymers / Aliphatic polyesters / Lactide / Caprolactone / Depsipeptide / Optical activity / Functionalized copolymers / Reactive double bond / 環状カーボネート / 熱的・機械的特性 / ラクトン / 4-アルキルカプロラクトン / エチレンカーボネート / 金属含有触媒 |
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| Research Abstract |
Poly (L-1actic acid), namely poly (L-lactide) [poly (L-LA)] has such advantages as good biocompatibility and mechanical properties. However, the major problems of poly (L-LA) are its brittleness and low biodegradability. Therefore, in this work, to improve these disadvantages of poly (L-LA), but keeping its advantages, we have prepared novel biodegradable aliphatic polyesters. The following significant results were obtained
Improvement of biodegradability of poly (L-LA) by introducing depsipetide (DP) units ; The enzymatic degradation of poly (L-LA) was much improved by copolymerizing DP monomer (DPs were synthsized from various amino asids and hydoxy acid derivatives). Furthermore, it was found that the biodegradability was most improved by using DP monmers prepared from L-isomers of amino asids.
Improvement of brittleness of poly (L-LA) chains ; The introduction of caprolactone (CL) or its derivative (4-alkylated caprolactone) units into poly (L-LA) chains resulted in a greater improvement of the brittleness of poly (L-LA). And this enabled us to regulate the degradability of copolymers.
The above results rendered us to prepare DP/CL/L-LA terpolymers. The terpolymer with composition ratio about 5/20/75 was found to be the best polymer judging by the balance of biodegradability and properties.
For many applications of biodegradable polymers, functionalizations of these polymers are very important. We have therefore prepared L-LA copolymers having various **nctinal groups. For example, CL/L-LA copolymers with hydroxy group was found to be highly biodegradable compared with poly (L-LA). Further, we have synthesized the copolymers with multifunctional groups (double bond/epoxy/diol) by transforming the reactive double bond of polymers into these functional groups. Finally, we have succeeded in developing cross-linked hydrogel polymers by chemical modification of these groups.
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