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Roles of guanylyl cyclase system in adaptation to the environment

Research Project

Project/Area Number 11236202
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionHokkaido University

Principal Investigator

SUZUKI Norio  Hokkaido University, Graduate School of Science, Professor, 大学院・理学研究科, 教授 (20082133)

Co-Investigator(Kenkyū-buntansha) KUSAKABE Takehiro  Hokkaido University, Graduate School of Science, Research Associate, 大学院・理学研究科, 助手 (40280862)
Project Period (FY) 1999 – 2003
Project Status Completed (Fiscal Year 2003)
Budget Amount *help
¥65,600,000 (Direct Cost: ¥65,600,000)
Fiscal Year 2003: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2002: ¥10,000,000 (Direct Cost: ¥10,000,000)
Fiscal Year 2001: ¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2000: ¥15,200,000 (Direct Cost: ¥15,200,000)
Fiscal Year 1999: ¥15,800,000 (Direct Cost: ¥15,800,000)
Keywordsmembrane guanylyl cyclase / soluble guanylyl cyclase / nitric oxide / atrial natriuretic peptide / in situ hybridization / morpholino / medaka fish / cGMP / 遺伝子 / ゲノム / シグナル伝達 / グアニル酸シクラーゼ / 発現制御 / プロモーター / ゲノム構造 / 遺伝子発現 / 転写 / シス要素 / スプライス変異 / 網膜 / 情報伝達 / リガンド / 受容体
Research Abstract

We demonstrated that binding of a protein with 17 kDa, which is a medaka fish homologue of mammalian co-activator "PC4", to the nucleotides (AGACCTTTGC) between-90 and -81 in the 5'-flanking region of the OIGC6 gene are essential for transcription of the OlGC6 gene in medaka fish intestine. In European eel, it has been demonstrated that expression of the GC-C2 transcript in the intestine was increased by 100% following the transfer of yellow fresh water-acclimated eels to sea water, while no changes in expression of OlGC9 were seen when adult medaka fish individuals were transferred to 500/0 sea water. Expression of neuronal NO synthase gene (nNOS), three different subunit genes (OlGCS-α_1, OlGCS-α_2, and OlGCS-β_1) of soluble GC, and three PKG genes (PKG 1α ; PKG 1β, and PKG II) were examined during embryogenesis of medaka fish with or without morpholino antisense oligonucleotide of respective gene. nNOS and OlGCS-β_1 were expressed matemally and OlGCS-α_1, OlGCS-α_2, PKG I, and PKG II were expressed zygotically. The zygotic expression of OlGCS-α_1 was detected at stage 19, while that of OlGCS-a2 was detected at stage 16. The Hong Kong-originated medaka fish Oryzias curvinotus expresses nine genes (OcGC1-OcGC8 and OcGC-R2) for membrane GCs and three genes (OcGCS-_1 OcGCS-_2, and OcGCS-_1) for soluble GC subunits. O. curvinotus was able to produce the hybrids with O. latipes irrespective of the direction of crossing and the resulting hybrids expressed both the matemal and patemal soluble GC subunit genes almost equally, suggesting the possibility of the formation of chimeric heterodimer in the hybrids.

Report

(6 results)
  • 2003 Annual Research Report   Final Research Report Summary
  • 2002 Annual Research Report
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (69 results)

All Other

All Publications (69 results)

  • [Publications] Fujie, S.: "Nitric oxide synthase and soluble guanylyl cyclase underlying the modulation of electrical oscillation in a central olfactory organ."J.Neurobiol. (In press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yao, Y.: "Genomic structure and expression of the soluble guanylyl cyclase α_2 subunit gene in the medaka fish Oryzias latipes. Zool.Sci."Zoological Science. 20. 1293-1304 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inoue, K.: "Four functionally distinct C-type natriuretic peptides found in fish reveal new evolutionary history of the natriuretic peptide system"Proc.Natl.Acad.Sci.USA. 100. 10079-10084 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagami, S.: "Expression and, genomic organization of a medaka fish novel membrane form of guanylyl cyclase/orphan receptor."Zoological Science. 20. 591-606 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, T.: "Localization of the NO1cGMP signaling pathway-related genes and influences of soluble GC molpholino Knock-down on medaka fish embryogenesis"Zoological Science. 20. 181-191 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Harumi, T.: "Expression of membrane-bound and soluble guanylyl cyclase mRNAs in embryonic and adult retina of the medaka fish Oryzias latipes."Zoological Science. 20. 133-140 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakauchi, M.: "Promoter analysis of a medaka fish intestinal guanylyl cyclase gene."FEBS Lett.. 536. 12-18 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikukawa, Y: "The 26S proteasome Rpn10 gene encoding splicing isoforms : Evolutional conservation of the genomic organization in vertebrates"Biol.Chem.. 383. 1257-1261 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, T.: "Promoter activity of the 5'-flanking regions of medaka fish soluble guanylyl cyclase α_1 and β_1, subunit genes."Biochem.J.. 361. 337-345 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroda, R.: "Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca^<2+> transients in fertilization of sea urchin eggs."Development. 128. 4405-4414 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanabe, Y.: "Genomic structure and expression of the sea urchin soluble guanylyl cyclase β subunit gene."Zoological Science. 18. 811-817 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagami, S.: "Expression and exon/intron organization of two medaka fish homologs of the mammalian guanylyl cyclase A."J.Biochem.. 130. 39-50 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Xu, S.H.: "Expression of sperm-activating peptide IV receptor-associated membrane guanylyl cyclase in the testis of the sea urchin Diadema setosum."Zoological Science. 18. 687-693 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusakabe, T.: "A cis-regulatory element essential for photoreceptor cell-specific expression of a medaka retinal guanylyl cyclase gene."Dev.Genes Evol.. 211. 145-149 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Ku sakabe, T.: "hotoreceptors and olfactory cells express the same retinal guanylyl cyclase isoform in medaka : visualization by promoter transgenics."FEBS Lett.. 483. 143-148 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomura, K.: "False fertilization in sea urchin eggs induced by diabolin, a 120K kelp protein."Biochem.Biophys.Res.Commun.. 272. 691-693 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusakabe, T.: "The guanylyl cyclase family in medaka fish Dryzias latipes."Zoological Science. 17. 131-140 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naruse, K.: "A detailed linkage map of medaka, Oryzias latipes : Comparative genomics and genome evolution."Genetics. 154. 1773-1784 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shibata, Y.: "Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon fertilization."J.Biol.Chem.. 275. 8349-8354 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Shiga, T., Suzuki, N.: "Expression of the guanylyl cyclase genes in the medaka fish hybrids between Oryzias curvinotus and Oryzias latipes."Submitted to Comp. Biochem. Physiol.. (2004)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Fujie, S., Yamamoto, T., Murakami, J., Hatakeyama, H.Shiga, H., Suzuki, N., Ito, E.: "Nitric oxide synthase and soluble guanylyl cyclase underlying the modulation of electrical oscillation in a central olfactory organ."J. Neurobiol., in press..

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yao, Y., Yamamoto, T., Tsutsumi, M., Matsuda, M., Hori, H., Naruse, K., Mitani, H., Shima, A., Asakawa, S., Shimizu, N., Suzuki, N.: "Genomic structure and expression of the soluble guanylyl cyclase a_2 subunit gene in the medaka fish Oryzias latipes."Zool. Sci.. 20. 1293-1304 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Inoue, K., Naruse, K., Yamagami, S., Mitani, H., Suzuki, N., Takei Y.: "Four functionally distinct C-type natriuretic peptides found in fish reveal new evolutionary history of the natriuretic peptide system."Proc. Natl. Acad. Sci. USA. 100. 10079-10084 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagami, S., Xu, S.H., Suzuki, N.: "Expression and genomic organization of a medaka fish novel membrane form of guanylyl cyclase/orphan receptor."Zool. Sci.. 20(5). 591-606 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, T., Yao, Y., Harumi, T., Suzuki, N.: "Localization of the NO/cGMP signaling pathway-related genes and influences of soluble GC molpholino Knock-down on medaka fish embryogenesis."Zool. Sci.. 20. 181-191 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Harumi, T., Watanabe, T., Yamamoto, T., Tanabe, Y., Suzuki, N.: "Expression of membrane-bound ad soluble guanylyl cyclase mRNAs in embryonic and adult retina of the medaka fish Oryzias latipes."Zool. Sci.. 20. 133-140 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nakauchi, M., Suzuki, N.: "Promoter analysis of a medaka fish intestinal guanylyl cyclase gene."FEBS Lett.. 536. 12-18 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kikukawa, Y., Shimada, M., Suzuki, N., Tanaka, K., Yokosawa, H., Kawahara, H.: "The 26S proteasome Rpn10 gene encoding splicing isoforms : Evolutional conservation of the genomic organization in vertebrates."Biol. Chem.. 383. 1257-1261 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamamoto, T., Suzuki, N.: "Promoter activity of the 5'-flanking regions of medaka fish soluble guanylyl cyclase a_1 and b_1 subunit genes."Biochem. J.. 361. 337-345 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kuroda, R., Kontani, K., Kanda, Y., Katada, Nakano, T., Satoh, Y., Suzuki, N., Kuroda, H.: "Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca^<2+> transients in fertilization of"Development. 128. 4405-4414 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Tanabe, Y., Suzuki, N.: "Genomic structure and expression of the sea urchin soluble guanylyl cyclase b subunit gene."Zool. Sci.. 18. 811-817 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yamagami, S., Suzuki, K., Suzuki, N.: "Expression and exon/intron organization of two medaka fish bomologs of the mammalian guanylyl cyclase A."J. Biochem.. 130. 39-50 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Xu, S.H., Yamagami, S., Nomura, K., Suzuki, N.: "Expression of sperm-activating peptide IV receptor-associated membrane guanylyl cyclase in the testis of the sea urchin Diadema setosum."Zool. Sci.. 18. 687-693 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusakabe, T., Suzuki, N.: "A cis-regulatory element essential for photoreceptor cell-specific expression of a medaka retinal guanylyl cyclase gene."Dev. Genes Evol.. 211. 145-149 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusakabe, T., Suzuki, N.: "Photoreceptors and olfactory cells express the same retinal guanylyl cyclase isform in medaka : visualization by promoter transgenics."FEBS Lett.. 483. 143-148 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Nomura, K., Nakamura, H., Suzuki N.: "False fertilization in sea urchin eggs induced by diabolin, a 120K help protein."Biochem. Biophys. Res. Commun.. 272. 691-693 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Kusakabe, T., Suzuki N.: "The guanylyl cyclase family in medaka fish Oryzias latipes."Zool. Sci.. 17. 131-140 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Naruse, K., Fukamachi, S., Mitani, H., Kondo, M., Matsuoka, T., Kondo, S., Hamamura, N., Morita, Y., Hasegawa, K., Mishigaki, R., Shimada, A., Wada, H., Husakabe, T., Suzuki, N., Kinoshita, M., Kanamori, A., Terado, T., Kimura, H., Nonaka, M., Shima, A.: "A detailed l, inkage map of medaka, Oryzias latipes : Comparative genomics and genome evolution."Genetics. 154. 1773-1784 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Y.Shibata, T.Iwamatsu, Y.Oba, D.Kobayashi, M.Tanaka, Y.Nagahama, N.Suzuki, M.Yoshikuni: "Identification and cDNA cloning of alveolin, an extracellular metalloproteinase, which induces chorion hardening of medaka (Oryzias latipes) eggs upon"J. Biol. Chem.. 275. 8349-8354 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2003 Final Research Report Summary
  • [Publications] Yao, Y, Yamamoto, T, Tsutsumi, M, et al., Suzuki, N.: "Genomic structure and expression of the soluble guanylyl cyclase alpha-2 subunit gene in the medaka fish Oryzias latipes"Zoological Science. 20. 1293-1304 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Inoue, K, Naruse, K, Yamagami, 5, Mitani, H, Suzuki, N, Takei, Y.: "Four functionally distinct C-type natriuretic peptides found in fish reveal new evolutionary history of the natriuretic peptide system"Proceeding of the National Academy of Science, USA. 100. 10079-10084 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamagami, S., Xu, S.H., Suzuki, N.: "Expression and genomic organization of a medaka fish novel membrane form of guanylyl cyclase/orphan receptor"Zoological Science. 20. 591-606 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Yamamoto, T., Yao, Y., Harumi, T, Suzuki, N.: "Localization of the NO/cGMP signaling pathway-related genes and influences of soluble GC knock-down on medaka embryogenesis"Zoological Science. 20. 181-191 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Harumi, T., Watanabe, T, Yamamoto, T, Suzuki.N.: "Expression of membrane-bound and soluble guanylyl cyclase mRNAs in embryonic and adult retina of the medaka fish Oryzias latipes"Zoological Science. 20. 133-140 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] Nakauchi, M., Suzuki, N.: "Promoter analysis of a medaka fish intestinal guanylyl cyclase gene"Federation of European Biochemical Society Letters. 536. 12-18 (2003)

    • Related Report
      2003 Annual Research Report
  • [Publications] 鈴木範男: "分子細胞生物学の基礎"三共出版. 216 (2004)

    • Related Report
      2003 Annual Research Report
  • [Publications] M.Nakauchi, N.Suzuki: "Promoter analysis of a medaka fish intestinal guanylyl cyclase gene"FEBS Letters. (in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yamamoto, Y.Yao, T.Harumi, N.Suzuki: "Localization of the nitric oxide/cGMP signaling pathway-related genes and influences of moipholino knock-down of soluble guanylyl cyclase on medaka fish embryogenesis"Zoological Science. 20(2)(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Harumi, T.Watanabe, T.Yamamoto, Y.Tanabe, N.Suzuki: "Expression of membrane-bound and soluble guanylyl cyclase mRNAs in embryonic and adult retina of the medaka fish Orvzias latipes"Zoological Science. 20(2)(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] S.Yamagami, S.H.Xu, N.Suzuki: "Expression and genomic organization of a medaka fish novel membrane form of guanylyl cyclase/orphan receptor"Zoological Science. 20(3)(in press). (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] Takehiro Kusakabe: "A cis-regulatory element essential for photoreceptor cell-specific expression of a medaka retinal guanylyl cyclase gene"Development, Genes and Evolution. 211. 145-149 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shan Hua Xu: "Expression of sperm-activating peptide IV receptor-associated membrnane guanylyl cyclase in the testis of the sea urchin"Zoological Science. 18. 687-693 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sayaka Yamagami: "Expression and exon/intron organization of two medaka fish homologs of the mammalian guanylyl cyclase A"Journal of Biochemistry. 130. 39-50 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yasunori Tanabe: "Genomic structure and expression of the sea urchin soluble guanylyl cyclase β subunit gene"Zoological Science. 18. 811-817 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ritsu Kuroda: "Increase of cGMO, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca^<2+> transients in fertilization of sea urchin eggs"Development. 128. 4405-4414 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takehiro Yamamoto: "Promoter activity of the 5'-flanking regions of medaka fish soluble guanylyl cyclase α1 and β1 subunit genes"Biochemical Journal. 361. 337-345 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Y.Shigata: "Identification and cDNA cloning of alveolin, an extracellular metallo-proteinase, which induces chorion hardening of medaka (Oryzisa latipes) egg upon fertilization"J.Biol.Chem. 275. 8349-8354 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Naruse: "A detailed linkage map of medaka, Oryzias latipes : Comparative genomics and genome evolution"Genomics. 154. 1773-1784 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Kusakabe: "The guanylyl cyclase family in medaka fish Oryzias latipes"Zool.Sci.. 17. 131-140 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] K.Nomura: "False fertilization in sea archin eggs induced by diabolim, a 120K protein."Biochem.Biophys.Res.Commun.. 272. 691-693 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Kusakabe: "Photo receptors and olfactory cells express the same retinal guanylyl cyclase isoform in medaka fish : visualiztion by promoter transgenesis"FEBS Lett.. 483. 143-148 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Kusakabe: "A cis-regulatory element essential for photoreceptor cell-specific expression of a medaka retinal guanylyl cyclase gene"Dev.Gene Evol.. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Mantoku: "Sequence analysis of eDNA and genomic DNA, and mRNA expression of the medaka fish homolog of the mammalian guanylyl cyclase C"J. Biochem.. 125. 476-486 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K..Nomura: "The primary and higher order structures of sea urchin ovoperoxidase as determined by cDNA cloning and predicted by homology modeling"Arch. Biochem. Biophys.. 367. 173-184 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Mikami: "Tandem organization of medaka fish soluble guanylyl cyclase α_1 and β_1 subunit genes : Implications for co-ordinated transcription of two subunits genes"J. Biol. Chem.. 274. 18567-18573 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Suzuki: "Molecular phylogenetic analysis of diverse forms of echinoderm guanylyl cyclases"Zool. Sci.. 16. 515-527 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] K.Takeda: "Genomic structure and expression of the medaka fish homo log of the mammalian guanylyl cyclase B"J. Biochem.. 126. 104-114 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] R. Kusakabe: "Invivo analysis of two striated muscle actin promoters reveals combinations of multiple regulatory modules required for skeletal and muscle specific gene expression"Int. J. Dev. Biol.. 43. 541-554 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Suzuki: "The Male Gamete from Basic Science to Clinical Application"Cache River Press. 516 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2018-03-28  

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