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Occurrence of Sleepiness and Mechanism of Attention during Sleep

Research Project

Project/Area Number 11301003
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field 実験系心理学
Research InstitutionHIROSHIMA UNIVERSITY

Principal Investigator

HORI Tadao  Hiroshima University, Faculty of Integrated Arts and Sciences, Professor, 総合科学部, 教授 (10020132)

Co-Investigator(Kenkyū-buntansha) NITTONO Hiroshi  Hiroshima University, Faculty of Integrated Arts and Sciences, Research Associate, 総合科学部, 助手 (20304371)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥25,430,000 (Direct Cost: ¥24,500,000、Indirect Cost: ¥930,000)
Fiscal Year 2001: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2000: ¥9,000,000 (Direct Cost: ¥9,000,000)
Fiscal Year 1999: ¥12,400,000 (Direct Cost: ¥12,400,000)
Keywordssleep / sleep onset period / REM sleep / attention / neural mechanism / electroencephalogram / event-related potential / autonomic nervous system / 注意機構 / K複合 / 自律神経系活動 / 心拍数 / 血圧 / 睡眠紡錘波 / P300 / P400 / ミスマッチ陰性電位 / MMN / P240 / トポグラフィ分析 / 刺激弁別
Research Abstract

Attention mechanism (or environment monitoring system) during sleep was investigated in normal young adults using non-invasive psychophysiological measures. First, sleep onset period was classified into five stages according to characteristic patterns of electroencephalogram (EEG). Event-related potentials (ERPs) were recorded to examine the responsiveness to auditory stimuli at each EEG stage. When alpha waves characteristics of wakefulness flattened and theta waves characteristics of sleep emerged, wake-specific ERPs (e.g., mismatch negativity and P300) disappeared and sleep-specific ERPs (e.g., P200 and P400) appeared. Unlike the wake-specific ERPs, the sleep-specific ERPs were evoked independently of voluntary attention to the stimuli, indicating that they were exogenous components. Similar sleep-specific ERPs were observed also in stage 2 sleep and REM sleep. In subsequent studies, the relationship between the change of central nervous system and that of autonomic nervous system w … More as examined. Heart rate and blood pressure were recorded continuously during a daytime nap. Heart rate increased a few minute before awakening, suggesting that preparation for awakening progressed internally during sleep. This heart rate change was accompanied with a sustaining light sleep characterized by early EEG stages, whereas blood pressure did not show any corresponding change. On the basis of these findings, we proposed the following model of attention during sleep :
(1) In the wake-sleep transition period, directing attention voluntarily to environmental events becomes difficult. Neural mechanism of attention during wakefulness is replaced by a sleep-specific mechanism that detects infrequent events automatically.
(2) This sleep-specific neural mechanism works all night (in both non-REM and REM sleep) for monitoring whether an unusual event occurs in the environment, although the sensitivity of this system is lower than that in wakefulness.
(3) The switching of neural mechanisms from wakefulness to sleep is partly associated with the change of autonomic nervous activities. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (31 results)

All Other

All Publications (31 results)

  • [Publications] Tanaka, H. et al.: "Topographic mapping of EEG spectral power and coherence in delta activity during the transition from wakefulness to sleep"Psychiatry and Clinical Neurosciences. 53(2). 155-157 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 堀忠雄他: "入眠期におけるERP中・後期成分のトポグラフィ変動"臨床脳波. 41(10). 637-642 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda, K. et al.: "Estimation of generator sources of human sleep spindles by dipole tracing method"Psychiatry and Clinical Neurosciences. 54(3). 270-271 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 堀 忠雄: "睡眠中の注意(見張り番)機構と事象関連電位"基礎心理学研究. 19(1). 60-65 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 上田一貴他: "睡眠段階2における14Hz・12Hz睡眠紡錘波の電位発生源"広島大学総合科学部紀要IV理系編. 26(1). 1-14 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nittono, H. et al.: "The vanishing point of the mismatch negativity at sleep onset"Clinical Neurophysiology. 112(5). 732-739 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda, K. et al.: "Spatiotemporal changes of slow wave activities before and after 14 Hz/12 Hz sleep spindles during stage 2 sleep"Psychiatry and Clinical Neurosciences. 55(3). 183-184 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 甲斐田幸佐他: "自己覚醒法による短時間仮眠後の睡眠慣性抑制効果"生理心理学と精神生理学. 19(1). 7-14 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 甲斐田幸佐他: "自己覚醒を利用した短時間仮眠の睡眠構造と睡眠慣性に及ぼす効果"広島大学総合科学部紀要IV理系編. 27(1). 1-11 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahara, M. et al.: "Comparison of the event-related potentials between tonic and phasic periods of REM sleep"Psychiatry and Clinical Neurosciences. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka, H. et al.: "Topographic mapping of EEG spectral power and coherence in delta activity during the transition from wakefulness to sleep"Psychiatry and Clinical Neurosciences. 53(2). 155-157 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hori, T., et al.: "Topographical changes of middle-late components of ERP in the sleep onset period"Rinsho Nouha (Clinical Electroencephalography). 41(10). 637-642 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda, K., et al.: "Estimation of generator sources of human sleep spindles by dipole tracing method"Psychiatry and Clinical Neurosciences. 54(3). 270-271 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hori, T.: "Scanning function (night-watching system) of environment and event-related potentials (ERP) during sleep"The Japanese Journal of Psychonomic Science. 19(1). 60-65 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda, K., et al.: "Generator sources of 14 Hz/12 Hz sleep spindles during stage 2 sleep"Memoirs of the Faculty of Integrated Arts and Sciences, Hiroshima University (Science Reports). 26. 1-14 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nittono, H., et al.: "The vanishing point of the mismatch negativity at sleep onset"Clinical Neurophysiology. 112(5). 732-739 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ueda, K., et al.: "Spatiotemporal changes of slow wave activities before and after 14 Hz/12 Hz sleep spindles during stage 2 sleep"Psychiatry and Clinical Neurosciences. 55(3). 183-184 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kaida, K., et al.: "Preventive effects of self-awakening on sleep inertia after a short nap"Japanese Journal of Physiological Psychology and Psychophysiology. 19(1). 7-14 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kaida, K., et al.: "The effect of self-awakening on sleep structure and sleep inertia from a short nap"Memoirs of the Faculty of Integrated Arts and Sciences, Hiroshima University (Science Reports). 27. 1-11 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahara, M., et al.: "Comparison of the event-related potentials between tonic and phasic periods of REM sleep"Psychiatry and Clinical Neurosciences. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 堀 忠雄: "睡眠中の注意(見張り番機構)と事象関連電位"基礎心理学研究. 19(1). 60-65 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nottono, H., Momose, D., Hori, T.: "The vanishing point of the mismatch negativity at sleep onset"Clinical Neurophysiology. 112(5). 732-739 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ueda, K., Nittono, H., Hayashi, M., Hori, T.: "Spatiotemporal changes of slow wave activities before and after 14Hz/12Hz sleep spindles during stage 2 sleep"Pshychiatry and Clinical Neurosciences. 55(3). 183-184 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hori, T., Kataoka, N., Nittono, H., Hayashi, M.: "Topographical changes of late positive components of the event-related potential in the sleep onset period"Actas de Fisiologia. 7(1). 176 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 甲斐田幸佐, 入戸野 宏, 林 光緒, 堀 忠雄: "自己覚醒を利用した短時間仮眠の睡眠構造と睡眠完成におよぼす効果"広島大学総合科学部紀要IV理系編. 27(1). 1-11 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahara, M., Nittono, H., Hori, T.: "Comparison of the event-related potentials between tonic and phasic periods of REM sleep"Psychiatry and Clinical Neurosciences. (In press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nittono,H.,Momose,D.,& Hori,T: "The vanishing point of the mismatch negativity at sleep onset"Clinical Neurophysiology. (In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 堀忠雄: "睡眠中の注意(見張り番機構)と事象関連電位"基礎心理学研究. 19・1. 60-65 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 堀忠雄,入戸野宏: "眠気の発生と睡眠中の注意機構(1)-入眠期におけるミスマッチ陰性電位(MMN)の変化-"日本心理学会第64回大会発表論文集. 335 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ueda,K.,Nittono,H.,Hayashi,M.& Hori,T.: "Topographical changes of slow wave activities before and after appearance of 14 Hz/12 Hz sleep spindles"Journal of Sleep Research. 9 Suppl.1. 195 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nittono,H.et al.: "Gradual changes of mismatch negativity during the sleep onset period."Sleep Research Online. 2(Suppl.1). 287 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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