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Molecular mechanisms of and novel pathomorphological bases on vasculitis syndromes

Research Project

Project/Area Number 11307003
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionEhime University

Principal Investigator

NOSE Masato  Ehime Univ., Sch. Med., Pathol., Prof., 医学部, 教授 (70030913)

Co-Investigator(Kenkyū-buntansha) MIYACHI Yoshiki  Kyoto Univ., Grad. Sch. Med., Dermatol., Prof., 大学院・医学研究科, 教授 (30127146)
SUEISHI Katsuo  Kyushu Univ., Sch. Med,, Pathol., Prof., 大学院・医学研究院・医学部, 教授 (70108710)
YOSHIKI Takashi  Hokkaido Univ., Sch. Med., Pathol., Prof., 医学部, 教授 (60220612)
NAKAHAYASHI Kimimasa  Kyorin Univ., Sch. Med., Intern. Med., Prof., 医学部, 教授 (90086603)
YUTANI Chikao  National Cardiovascular Center, Pathol. Chief., 臨床検査部, 部長
沼野 藤夫  東京医科歯科大学, 医学部, 教授 (40013958)
油谷 親夫  国立循環器病センター, 臨床検査部, 部長
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥40,590,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2001: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2000: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 1999: ¥14,100,000 (Direct Cost: ¥14,100,000)
Keywordsangiogenesis / vascular remodeling / vasculitogenic antibodies / T cell clonality on vasculitis / vasculitogenic viruses / animal models for vasculitis / genomics of vasculitis / positional candidate genes for vasculitis / 血管内皮細胞 / ANCA / HTLV-1 / HCMV / ケモカインアンタゴニスト / 血管炎感受性遺伝子 / SNP / 原発性肺高血圧 / 高安動脈炎 / MPO / CD72 / ウイルス / 接着分子 / サイトカイン / アポトーシス / 自己抗体 / 転写因子 / 感受性遺伝子 / ゲノム
Research Abstract

Recent advances in vascular cell biology may make it possible to clarify the molecular mechanisms and pathomorphological bases of vasculitis syndromes. We thus performed several projects to take a new turn as follows.
1 Molecular pathological analyses of the phenotypic expression of vascular cells: 1) cross talks among cells and molecules in vasculitis (adhesion molecules, histamine, NO, apoptosis, vascular remodeling), 2) angiogenesis (gene expression, FGF-2/VEGF, a new differentiation pathway of endothelial cells, three dimensional analysis), 3) pathomorphological features specific for diseases (IAAA, pulmonary plexiform angiopathy, Takayasu arteritis, MPA, intra-hepatic vasculitis in collagen disease, arteriosclerosis, vasa-vasoritis),
2 Affecting and modifying host factors in vascular injury: 1) ANCA (mechanisms of vascular injury, tissue distribution of vasculitis, regular variations of glomerular lesions, Takayasu arteritis), 2) serum factors (anti-endothelial cell antibodies, rheu … More matoid factors, anti-phospholipid syndrome, antibodies phagocytizable by endothelial cells), 3) T cell clonalities (GCA, pathophysiological dymanics, Takayasu arteritis, arteriosclerosis), 4) lysosomal enzymes (Kawasaki disease),
3 Animal models for vasculitis: 1) Kawasaki disease (C.albicans extract-induced vasculitis, MPO- knock out mice), 2) Virus-dependent vasculitis (HTLV-1 env-pX transgenic rat, HCMV-IE transgenic mice), 3) MRL mice for vasculitis in collagen disease (inhibition by IRF-1 trans gene and gene transfer of chemokine antagonist),
4 Genome analysis: 1) Takayasu arteritis (HLA polymorphism, SNP of lKBL1), 2) geographical pathology (Takayasu arteritis), 3) MRL mouse vasculitis (positional candidate genes, blood vessel-caliber specific gene loci, 35 recombinat inbred strains for vasculitis research), 4) Kawasaki disease model mice (vasculitis-resistant loci),
5 Extramural seminars: 1) "International Workshop on Systemic Vasculitis 2000", Tokyo, Oct. 14, 2000, 2) "New Developments in Vasculitis Research", Matsuyama, Feb. 16, 2002. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (241 results)

All Other

All Publications (241 results)

  • [Publications] Nakatsuru S, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Q WM, Morimoto K, Yazawa C, Ogasawara H, Abe Y, Fukui K, Ichien G, Ito RM, Mori S, Nakamura Y, Nose M.: "Genetic dissection of the complex pathological manifestataions of collagen disease in MRL/lpr mice"Pathol Int. 49. 974-962 (1999)

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  • [Publications] Nishihara M, Terada M, Kamogawa J, Ohashi Y, Mori S, Nakaturu S, Nakamura Y, Nose M.: "Genetic basis of autoimmune sialoadenitis in MRL/lpr lupus mice : additive and hierarchical properties on polygenic inheritance"Arthritis Rheum. 42. 2616-2623 (1999)

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  • [Publications] Nishimura H, Nose M, Hiai H, Minato N, Honjo T.: "Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-Carrying immunoreceptor"Immunity. 11. 141-151 (1999)

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  • [Publications] Katsumata K, Ikeda H, Sato M, Ishizu A, Kawarada Y, Kato H, Wakisaka A, Koite T, Yoshiki T.: "Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells"Clinical Immunol.. 98. 75-80 (1999)

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  • [Publications] Chen Y-X, Nakashima Y, Tanaka K, Shiraishi S, Nakagawa K, Sueishi K.: "Immunohistochemical expression of vascular endothelial growth factor(VEGF)/vascular permeability factor (VPG) in the atherosclerotic intimas of human coronary anthries"Arterioscler Thromb Vasc Biol. 19. 131-139 (1999)

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  • [Publications] Iwamoto H, Kiyohara Y, Fujishima M, Kato I, Nakayama K, Sueishi K, Tsuneyoshi M.: "Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy scries during a 30-year observation period. The Hisayama Study"Stroke. 30. 1390-1395 (1999)

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  • [Publications] Watanabe N, Akikusa B, Park SY, Ohno H, Fassati L, Vecchietti G, Gessner JE, Schmidt RE, Verbeek JS, Ryffel B, Izui S, Saito T.: "Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggerig Fc γ receptors"Blood. 94. 3855-3863 (1999)

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  • [Publications] Uzuki M, Watanabe T, Katsura Y, Sawai T.: "Quantitative histochemical study of hyalurinic acib binding protein and the activity of uridine diphosphoglucise dehydrogenase in the synovium of patients with rheumatoid arthritis"Anal Quant Cytol Histol. 21. 75-80 (1999)

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  • [Publications] Watanabe M, Sawai T.: "Alteration of cross-linking amino acids of elastin in human aorta in association with dissecting aneurysm : analysis using high performance liquid chromatography"Tohoku J Exp Med. 187. 291-303 (1999)

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  • [Publications] Watanabe M, Takahashi M, Sawai T.: "Unusual renal involvement of polymyositis complicated with malignant hypertension"Jpn J Rheum. 9. 381-390 (1999)

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  • [Publications] Ito M, Matsunaga K, Sano K, Sakaguchi N, Hotchi M.: "Intravascular fascilitis of the forearm vein : a case report with immunohistochemical characterization"Pathol Int. 49. 175-179 (1999)

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  • [Publications] Kitamura H, Kitamura H, Ito S, Kuwana N, Yutani C.: "Epithelioid hemangioma of the temporal artery clinically mimicking temporal arteritis"Pathol Int. 49. 831-835 (1999)

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  • [Publications] Ishibashi-Ueda H, Yutani C, Kuribayashi S, Takamiya M, Imakita M, Ando M: "Late in-stent restenosis of the abdominal aorta in a patient with Takayasu's arteritis and related pathology"Cardio Vascular & Interventional Padiology. 22. 333-336 (1999)

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  • [Publications] Yamada K, Sugimoto K, Matsumoto T, Narumi K, Oshimi K.: "All-trans retinoic acid-induced vasculitis and hemonecrosis of the ileum in a patient with acute promyelocytic leukemia"Leukemia. 13. 647-648 (1999)

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  • [Publications] Baba T, Itakura K, Tanaka R, Kawasaki I, Kiysawa M, Numano F.: "Importance of fluorescein angiographic study in a evaluationg early rental chances in Takayasu disease"Jpn Opthalmol. 43. 546-552 (1999)

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  • [Publications] Numano F, Gimbrone M.: "Inflammation and atherosclerosis"Atherosclerosis. 5. (1999)

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  • [Publications] Ishikawa O, Takahashi A, Tamura A, Miyachi Y.: "Cutaneous papules and nodules in the diagnosis of the antiphosphoilpid syndrome"Br J Dermatol. 140. 725-729 (1999)

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  • [Publications] Ishikawa O, Abe M, Miyachi Y.: "Herpes zoster in Japanese patients with systemic lupus eruthematosus"Clin Exp Dermatol. 24. 327-328 (1999)

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  • [Publications] Kurosawa M, Inamura H, Amano H, Kanbe N, Nagai H, Furukawa S, Miyachi Y.: "Nerve growth factor release with mast cell derived mediators in a patient with systemic mastocytosis after middle-wave ultraviolet irradiation"Allergy. 54. 994-998 (1999)

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  • [Publications] 伊藤美津子, 小野寺建, 阿部弘之, 三浦正悦, 能勢眞人: "バルサルバ洞動脈癌破裂に伴う大動脈弁断列にて急死した大量脈炎の一剖検例"リウマチ. 39. 853-859 (1999)

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  • [Publications] 能勢眞人: "血管炎の遺伝要因-モデルマウスのゲノム解析"治療学. 33. 152-156 (1999)

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  • [Publications] 能勢眞人: "血管炎モデルマウスのゲノム解析"Bio Clinica. 14. 320-322 (1999)

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  • [Publications] 能勢眞人: "自然発症疾患モデル動物:血管炎"Molecular Medicine. 36. 32-36 (1999)

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  • [Publications] 澤井高志, 宇月美和: "リウマチの病理-動物モデルの病態解明と治療への応用"病理と臨床(臨時増刊号・日本人の病気と病理学). 17. 321 (1999)

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  • [Publications] 沼野藤夫: "高安動脈炎"治療学. 33. 59-62 (1999)

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  • [Publications] 沼野藤夫: "血管炎における外膜の役割"血管と内皮. 9. 256-261 (1999)

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  • [Publications] Nose M, Nishihara M, Kamogawa J, Terada M, Nakaturu S.: "Genetic basis of autoimmune disease in MRL/lpr mice : dissection of the complex pathological manifestations and their susceptibility loci"Rez Immunogenetics. 2. 154-164 (2000)

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  • [Publications] Nose M, Nishihara M, Fujii H: "Genetic basis of the complex pathological manifestations of collagen disease : Lessons from MRL/lpr and related mouse models"Int Rev Immunol. 19. 473-498 (2000)

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  • [Publications] Nose M, Terada M, Nishihara M, Kamogawa J, Miyazaki T, Qu WM, Mori S, Nakatsuru S.: "Genome analysis of collagen disease in MRL/lpr mice : polygenic inheritance resulting in the complex pathological manifestations"Int J Cardiol. 75. S53-S61 (2000)

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  • [Publications] 能勢眞人: "膠原病の病像多様性・類似性の起源-モデルマウスに学ぶゲノム病理学"リウマチ. 40. 833-848 (2000)

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  • [Publications] Ito MR.Terasaki S, Kondo E, Shiwaku H, Fukuoka Y, Nose M.: "Experimental lupus nephritis in severe combined immunodeficient (SCID) mice : remodelling of the glomerular lesions by bystander IgM antibodies"Clin Exp Immunol. 119. 340-345 (2000)

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  • [Publications] Qu WM, Miyazaki T, Terada M, Lu LM, Nishihara M, Yamada A, Mori S, Nakamura Y, Ogasawara H, Yazawa C, Nakatsuru S, Nose M.: "Genetic dissection of vasculitis in MRL/lpr lupus mice : a novel susceptibility locus involving the CD72^c allele"Eru J Immunol. 30. 2027-2037 (2000)

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  • [Publications] 能勢眞人: "膠原病の病像多様性・類似性の起源-モデルマウスのゲノム解析によるアプローチ"日病会誌. 89. 41-59 (2000)

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  • [Publications] 石津明洋, 吉木 敬: "血管炎のモデル動物"最新医学. 55. 2611-2615 (2000)

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  • [Publications] Kurose A, Oyama K, Murakami Y, Ohyama K, Segawa I, Sawai T.: "Dillated cardiomyopathy in Noonan syndrome : A first autopsy case"Human Pathology. 31. 764-767 (2000)

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  • [Publications] 渡部徹雄, 澤井高志, 佐藤成, 宇月美和, 里見進: "腹部大動脈瘤におけるMatrix metalloproteinaseの役割"脈管学. 40. (2000)

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  • [Publications] 三浦康宏, 黒瀬顕, 吉田浩子, 井上洋西, 澤井高志: "免疫抑制療法が奏功したものの肺複合感染の併発により死亡したWegener肉芽腫症の一症例"臨床リウマチ. 12. 143-149 (2000)

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  • [Publications] Inder SJ, Bobryshev YV, Cherian SM, Wang AY, Lord RSA, Masuda K, Yutani C.: "Immunophenotypic analysis of the aortic wall in Takayasu's arteritis : involvement of lymphocytes, dendritic cells and granulocytes in immuno-inflammatory reactions"Cardiovas Surg. 8. 141-148 (2000)

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  • [Publications] Inder SJ, Bobryshev YV, Cherian SM, Lord RSA, Masuda K, Yutani C: "Accumulation of lymphocytes, dendritic cells, and granulocytes in the aortic wall affected by Takayasu's disease"Angiol. 51. 565-579 (2000)

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  • [Publications] Egashira K, Koyanagi M, Kitamoto S, Weihua N, Kataoka C, Morishita R, Kaneda Y, Akiyama C, Nishida K, Sueishi K, Takeshita K.: "Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats : blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthase"FASEB J. 14. 1974-1978 (2000)

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  • [Publications] Yoshikawa H, Ishibashi T, Hata Y, Inomata H, Sueishi K.: "The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities"Ophthalmic Res. 32. 261-269 (2000)

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  • [Publications] Nakagawa K, Chen Y-X, Ishibashi H, Yonemitsu Y, Murata T, Hata Y, Nakashima Y, Sueishi K.: "Angiogenesis and its regulation : roles of vascular endothelial cell growth factors"Semin Thromb Hemost. 26. 61-66 (2000)

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  • [Publications] Ogishima D, Matsumoto T, Nakamura Y, Yoshida K, Kuwabara Y.: "Placental pathology in systemic lupus erythematosis with antiphospholipid antibodies"Pathol Int. 50. 224-229 (2000)

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  • [Publications] Matsumoto T, Kobayashi S, Shimizu H, Nakajima M, Watanabe S, Kitami N, Sato N, Abe H, Aoki Y, Hoshi T, Hashimoto H.: "The liver in collagen disease : Pathologic study of 160 cases with particlar reference to primary biliary cirrosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver"Liver. 20. 366-373 (2000)

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  • [Publications] Numano F, Kishi Y, Tanaka A, Ohkawara M, Kakuta T, Kobayashi Y.: "Inflammation and atherosclerosis"Ann NY Acad Sci. 904. 65-76 (2000)

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  • [Publications] Numano F.: "Vasa vasoritis, vasculitis and atherosclerosis"Int J Cardiol. 75. 1-8 (2000)

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  • [Publications] Kimura A, Ota M, Katsuyama Y, Ohbuchi N, Takahashi M, Kobayashi Y, Inoko H, Numano F.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis"Int J Cardiol. 75. 105-110 (2000)

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  • [Publications] Numano F, Okawara M, Inomata H, Kobayashi Y.: "Takayasu's arteritis"Lancet. 356. 1023-1025 (2000)

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  • [Publications] 沼野藤夫: "血管炎成因とその病態-特にvasa vasoritisの果たす役割について"脈管学. 40. 959-965 (2000)

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  • [Publications] Nakabayashi K, Kamiya Y, Nagasawa T.: "Aortitis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody ; report of three cases"Int J Cardiol. 75. 89-94 (2000)

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  • [Publications] 中林公正: "中林公正:ANCA関連疾患の臨床"日内会誌. 89. 520-523 (2000)

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  • [Publications] Fujiwara T, Shimizu D, Kon K, Isshiki N, Tsunokuni H, Aoyagi S: "A new method for detecting and localizing cell markers endocytosed by fibroblasts in epoxy resin semi-thin sections using scanning electron microscopy combined with energy dispersive X-ray microanalysis after ion-etching"J Electr Microsc. 49. 551-558 (2000)

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  • [Publications] 岩政貴久恵, 小森浩章, 新谷泰成, 長谷川均, 酒井郁也, 藤田繁, 吉田美奈子, 能勢眞人: "Calf Painで発症したミエロペルオキシダーゼに対する抗好中球細胞質抗体(MPO-ANCA)弱陽性Polyarteritis Nodosaの1症例"リウマチ. 41. 875-879 (2001)

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  • [Publications] Takahashi S, Araki K, Araki M, Ito MR, Nakatani K, Fujii H, Izui S, Zassalli P, Nose M.: "Suppression of experimental lupus nephritis by aberrant expression of the solubl E-selectin gene"Pathol Int. (in press).

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  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M.: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains"Arthritis Rheum. (in press).

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  • [Publications] Ishizu A, Ogawa Y, Ishikura H, Yoshiki T.: "Anti-Thy-1 monodonal antibody with speciffic reactivity with vascular endothelial cells in rat glomeruli"Acta Histochem. 103. 279-286 (2001)

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    • Related Report
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  • [Publications] Nakamaru Y, Ishizu A, Ikeda H, Sugaya T, Fugo K, Higuchi M, Yamazaki H, Yoshiki T.: "Immunological hyperresponsiveness in HTLV-I LTR-env-pX transgenic rats : a prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases"Pathbiology. 69. 11-18 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Sugaya T, Ishizu A, Ikeda H, Nakamaru Y, Fugo K, Higuchi M, Yamazaki H, Imai K, Yoshiki T.: "Clonotypic analysis of T cells accumulating at arthritic lesions in HTLV-I env-pX transgenic rats"Exp Mol Pathol. 72. 56-61 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Tsukamoto Y, Matsuo N, zawa K, Hon O, Higashi T, Nishizaki J, Tohnai N, Nagata I, kawano K, Yutani C, Hirota S, Kitamura Y, Stem DM, Ogawa S.: "Expression of a novel RNA-splicing factor, RA3O1/Tra2 β, in vascular lesions and its role in smooth muscle cell proliferation"Am J Pathol. 158. 1685-1694 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 鈴木淳子, 富田幸子, 中澤 誠, 小松敬子, 由谷親夫, 川瀬昌司, 大塚拓治, 川端健二: "川崎病血管炎の免疫組織化学的検討"Prog Med. 21. 1676-1678 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Ikeda Y, Yonemitsu Y, Ishibashi T, Murata T, Ueno H, Kato A, Nagai Y, Fukumura M, Inomata H, Hasegawa M, Sueishi K.: "Recombinant Sendal virus-mediated gene transfer to the retinal tissue of adult rats : efficient gene transfer by brief exposure"Exp Eye Res. (in press).

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Nakashima Y, Chen Y-X, Kinukawa N, Sueishi K.: "Distributions of diffuse intimal thickening in human arteries : prefential expression in atherosclerosis-prone arteries from an early age"Virchows Arch. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Yonemitsu Y, Komori K, Sueishi K, Sugimachi K.: "Gene therapy in vascular surgery comes of age"Surgery. 131. 261-268 (2002)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Masaki I, Yonemitsu Y, Komori K, Ueno H, Nakashima Y, Nakagawa K, Fukumura M, Kato A, Hasan M, Nagal Y, Sugimachi K, Hasegawa M, Sueishi K.: "Recombinant Sendal virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J. 15. 1294-1296 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uzuki M, Sasano H, Muramatsu Y, Totsune K, Oki Y, Takahashi K, Jino K, Sawai T.: "Urocortin in the synovial tissue of patients with rheumatoid arthritis"Clinical Science. 100. 577-589 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kurose A, Yoshida W, Yoshida M, Sawai T.: "Effects of paclitaxel on cultured synovial cells from p-atients with rheumatoid arthritis"Cytometry. 44. 349-354 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Nakazawa F, Matsuno H, Yudoh K, Katayama R, Sawai T, Uzuki M, Kimura T.: "Methotrexate inhibits rheumatoid synovitis by inducing apoptosis"J Rheumatol. 28. 1800-1808 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 澤井高志, 宇月美和, 柴田祐二, 岩崎真弓, 三宮彰仁, 藤川博康, 中島洋: "生検像と臨床所見からHypereosinophilic Syndrome(HES)が疑われた症例"脈管学. (in press).

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 松本俊治, 福村由紀, 須田耕一: "膠原病における肝、胆管、膵の病理所見"胆と膵. 22. 397-402 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 神谷康司, 中林公正, 有村義宏, 長澤俊彦: "MPO-ANCA関連血管炎"日臨免会誌. 23. 661-664 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 有村義宏, 丸茂朋史, 藤井亜砂美, 中林公正, 長澤俊彦: "膠原病と自己抗体.抗好中球細胞質抗体(ANCA)-ELISAによるANCA測定-"臨床病理. 49. 571-574 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 中林公正, 神谷康司, 斉藤生朗: "膠原病関連大型血管炎の発症に関与する因子と治療法に関する臨床的解析"脈管学. 41. 397-401 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 神谷康司, 有村義宏, 中林公正: "血管炎における好中球の役割"Medicina. 38. 975-977 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Kitoh A, Nobuhara S, Takahashi K, Nishigori C, Miyachi Y.: "Churg-Strauss syndrome with renal involvement : A ease report"J Dermatol. 28. 71-74 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Matsumura Y, Tomimoto H, Yamarnoto M, Imamura S, Miyachi Y: "Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of Livedo vasculitis : A possible involvement of platelet activation"J Dermatol. 28. 508-510 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Yamaoka J, Kabashima K, Kawanishi M, Toda KI, Miyachi Y.: "Cytotoxicity of IFN-γ and TNF-α for vascular endothelial cell is mediated by nitric oxide"Biochem Biophys Res Commun. (in press).

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Shimizu D, Fujiwara T, Kon K, Issiki N, Tsunokuni H.: "Three-dimensional reconstruction by scanning electron microscopy from serial epoxy resin semi-thin sections after ion-etching"J Electr Microsc. 50. 51-55 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 小林 靖, 沼野藤夫: "血管炎症候群-分子レベルの解析から臨床まで:高安動脈炎の病態と分子遺伝学的解析"日本内科学会雑誌. 90. 90-93 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Kobayashi Y, Numano F: "Takayasu Arteritis"Internal Medicine. 41. 44-46 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Hasegawa H, Fujita S: "Chemokines and lymphocytes : The role of chemokines and their receptors in the immune system. : 599-607"Cell Mol Biol. 47. 599-607 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Nomura T, Hasegawa H, Kohno M, Sasaki M, Fujita S.: "Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1 chemokine genes"Int J Cancer. 91. 597-606 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 中林公正: "わかりやすい内科学(ヴエジナー肉芽腫症の項)"分光堂(井村裕夫、他編). (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Numano F.(分担): "Takayasu Arteritis, Inflammatory disease of blood vessel"Oxford Univ Press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Numano F.(分担): "Takayasu Arteritis, vascular manifestation of systemic autoimmune disease"CRC Press. (1999)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 石津明洋, 吉木 敬: "血管炎のモデル動物.血管炎(長澤俊彦監修、橋本博史編集)"朝倉書店. 365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 黒瀬 顕, 澤井高志: "血管炎における組織傷害機序.血管炎(長澤俊彦監修、橋本博史編)"朝倉書店. 365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 松本俊治, 三田村美紀子: "病理形態的・免疫組織化学的診断、血管炎(長澤俊彦監修、橋本博史編集)"朝倉書店. 365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 中林公正: "結節性多発動脈炎、血管炎.(長澤俊彦監修、橋本博史編)"朝倉書店. 365 (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] 宮地良樹: "血栓性静脈炎.皮膚疾患最新の治療(新村眞人、瀧川雅浩編)"南江堂. (2001)

    • Description
      「研究成果報告書概要(和文)」より
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      2001 Final Research Report Summary
  • [Publications] Nakatsuru S., et al.: "Genetic dissection of the manifestataions of collagen disease in MRL/lpr mice"Pathol Int. 49. 974-962 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nishihara M., et al.: "Genetic basis of autoimmune sialoadenitis in MRL/lpr lupus mice: additive and hierarchical properties on polygenic inheritance"Arthritis Rheum. 42. 2616-2623 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nishimura M., et al.: "Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-canying immunoreceptor"Immunity. 11. 141-151 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Katsumata K., et al.: "Cytokine regulation of env gene expression of human endogenous retrovirus-R in human vascular endothelial cells"Clinical Immunol. 93. 75-80 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Chen Y.-X., et al.: "Immunohistochemical expression of vascular endothelial growth factor (VEGF)/vascular permeability factor (VPG) in the atherosclerotic intimas of human coronary arteries"Arterioscler Thromb Vasc Biol. 19. 131-139 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Watanabe N., et al.: "Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggerig Fc γ receptors"Blood. 94. 3855-3863 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Watanabe M., et al.: "Alteration of cross-linking amino acids of elastin in human aorta in association with dissecting aneurysm: analysis using high performance liquid chromatography"Tohoku J Exp Med. 187. 291-303 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Watanabe M., et al.: "Unusual renal involvement of polymyositis complicated with malignant hypertension"Jpn J Rheum. 9. 381-390 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Ito M., et al.: "Intravascular fascilitis of the forearm vein: a case report with Immunohistochemical characterization"Pathol Int. 49. 175-179 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Kitamura H., et al.: "Epithelioid hemangioma of the temporal artery clinically mimicking temporal arteritis"Pathol Int. 49. 831-835 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Ishibashi-Ueda H., et al.: "Late in-stent restenosis of the abdominal aorta in a patient with Takayasu's arteritis and related pathology"Cardio Vasc Int Pad. 22. 333-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamada K., et al.: "All-trans retinoic acid-induced vasculitis and hemonecrosis of the ileum in a patient with acute promyelocytic leukemia"Leukemia. 13. 647-648 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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  • [Publications] Baba T., et al.: "Importance of fluorescein angiographic study in a evaluationg early rental chances in Takayasu disease"Jpn Opthalmol. 43. 546-552 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Numano F., et al.: "Inflammation and atherosclerosis"Atherosclerosis. 5. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishikawa O., et al.: "Cutaneous papules and nodules in the diagnosis of the antiphosptiolrpid syndrome"Br J Dermatol. 140. 725-729 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Ishikawa O., et al.: "Herpes zoster in Japanese patients with systemic lupus eruthematpsus"Clin Exp Dermatol. 24. 327-328 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nose M., et al.: "Genetic basis of autoimmune disease in MRL/lpr mice: dissection of the complex pathological manifestations and their susceptibility loci"Rev Immunogenetics. 2. 154-164 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nose M., et al.: "Genetic basis of the complex pathological manifestations of collagen disease: Lessons from MRL/lpr and related mouse models"Int Rev Immunol. 19. 473-498 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nose M., et al.: "Genome analysis of collagen disease in MRL/lpr mice: polygenic inheritance resulting in the complex pathological manifestations"Int J Cardiol. 75. S53-S61 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ito M., et al.: "Experimental lupus nephritis in severe combined immunodeficient (SCID) mice: remodelling of the glomerular lesions by bystander IgM antibodies"Clin Exp Immunol. 119. 340-345 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Qu W.M., et al.: "Genetic dissection of vasculitis in MRL/lpr lupus mice: a novel susceptibility locus involving the CD72^c allele"Eur J Immunol. 30. 2027-2037 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Inder S.J., et al.: "Immunophenotypic analysis of the aortic wall in Takayasu's arteritis: involvement of lymphocytes, dendritic cells and granulocytes in immuno-inflammatory reactions"Cardiovas Surg. 8. 141-148 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Inder S.J., et al.: "Accumulation of lymphocytes, dendritic cells, and granulocytes in the aortic wall affected by Takayasu's disease"Angiol. 51. 565-579 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Ogishima D., et al.: "Placental pathology in systemic lupus erythematosis with antipho spholipid antibodies"Pathol Int. 50. 224-229 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
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      2001 Final Research Report Summary
  • [Publications] Nakagawa K., et al.: "Angiogenesis and its regulation: roles of vascular endothelial cell growth factors"Semin Thromb Hemost. 26. 61-66 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Egashira K., et al.: "Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: blockade of MCP-1 activity after Intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthase"FASEB J. 14. 1974-1978 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumoto T., et al.: "The liver in collagen disease: Pathologic study of 160 cases with particular reference to primary biliary cirrosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver"Liver. 20. 366-373 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Numano F., et al.: "Inflammation and atherosclerosis"Ann NY Acad Sci. 904. 65-76 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Numano F.: "Vasa vasoritis, vasculitis and atherosclerosis"Int J Cardiol. 75. 1-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kimura A., et al.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis"Int J Cardiol. 75. 105-110 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Numano F., et al.: "Takayasu's arteritis"Lancet. 356. 1023-1025 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakabayashi K., et al.: "Aorititis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody, report of three cases"Int J Cardiol. 75. 89-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fujiwara T., et al.: "A new method for detecting and localizing cell markers endocytosed by fibroblasts in epoxy resin semi-thin sections using scanning electron microscopy combined with energy dispersive X-ray microanalysis after ion-etching"J Electr Microsc. 49. 551-558 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takahashi S., et al.: "Suppression of experimental lupus nephritis by aberrant expression of the soluble E-selectin gene"Pathol Int. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kamogawa J., et al.: "Arthritis in MRL/lpr mice is under the control of multiple gene loci with an allelic combination derived from the original inbred strains"Arthritis Rheum. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ishizu A., et al.: "Anti-Thy-1 monoclonal antibody with specific reactivity with vascular endothelial cells in rat glomeruli"Acta Histochem. 103. 279-286 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakamaru Y., et al.: "Immunological hyperresponsiveness in HTLV-I LTR-env-pX transgenic rats: a prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases"Pathobiology. 69. 11-18 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsukamoto Y., et al.: "Expression of a novel RNA-splicing factor, RA301/Tra2β, in vascular lesions and its role in smooth muscle cell proliferation"Am J Pathol. 158. 1685-1694 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masaki I.: "Recombinant Sendai virus-mediated gene transfer to vasculature: a new class of efficient gene transfer vector to the vascular system"FASEB J. 15. 1294-1296 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Uzuki M., et al.: "Urocortin in the synovial tissue of patients with rheumatoid arthritis"Clinical Science. 100. 577-589 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kurose A., et al.: "Effects of paclitaxel on cultured synovial cells from patient with rheumatoid arthritis"Cytometry. 44. 349-354 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kito A., et al.: "Churg-Strauss syndrome with renal involvement: A case report"J Dermatol. 28. 71-74 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsumura Y., et al.: "Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of Livedo vasculitis: A possible involvement of platelet activatioin"J Dermatol. 28. 508-510 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu D., et al.: "Three-dimensional reconstruction by scanning electron microscopy from serial epoxy resin semi-thin sections after ion-etching"J Electr Microsc. 50. 51-55 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kobayashi Y., et al.: "Takayasu Arteritis"Internal Medicine. 41. 44-46 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hasegawa H. et al.: "Chemokines and lymphocytes: The role of chemokines and their receptors in the immune system"Cell Mol Biol. 47. 599-607 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nomura T., et al.: "Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1 chemokine genes"Int J Cancer. 91. 597-606 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yonemitsu Y., et al.: "Gene Therapy in vascular surgery comes of age"Surgery. 131. S261-268 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sugaya T., et al.: "clonotypic analysis of T cells accumulating at arthritic lesions in HTLV-I env-pX transgenic rats"Exp Mol Pathol. 72. 56-61 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ikeda Y., et al.: "Recombinant Sendai virus-mediated gene transfer to the retinal tissue of adult rats: efficient gene transfer by brief exposure"Exp Eye Res. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakashima Y., et al.: "Distributions of diffuse intimal thickening in human arteries: prefential expression in atherosclerosis-prone arteries from an early age"Virchows Arch. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yamaoka J., et al.: "Cytotoxicity of IFN-γ and TNF-α for vascular endothelial cell is mediated by nitric oxide"Biochem Bioph Res Co. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岩政貴久恵, 小森浩章, 新谷泰成, 長谷川均, 酒井郁也, 藤田繁, 吉田美奈子, 能勢眞人: "Calf Painで発症したミエロペルオキシダーゼに対する抗好中球細胞質抗体(MPO-ANCA)弱陽性Polyarteritis Nodosaの1症例"リウマチ. 41. 875-879 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Takahashi S, Araki K, Araki M, Ito MR, Nakatani K, Fujii H, Izui S, Zassalli P, Nose M: "Suppression of experimental lupus nephritis by aberrant expression of the solubl E-selectin gene"Pathol Int. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kamogawa J, Terada M, Mizuki S, Nishihara M, Yamamoto H, Mori S, Abe Y, Morimoto K, Nakatsuru S, Nakamura Y, Nose M: "Arthritis in MRL/lpr mice is under the control of multiple gene loci wit an allelic combination derived from the original inbred strains"Arthritis Rheum. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Ishizu A, Ogawa Y, Ishikura H, Yoshiki T: "Anti-Thy-1 monoclonal antibody with specific reactivity with vascular endothelial cells in rat glomeruli"Acta Histochem. 103. 279-286 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamaru Y, Ishizu A, Ikeda H, Sugaya T, Fugo K, Higuchi M, Yamazaki H, Yoshiki T: "Immunological hyperresponsiveness in HTLV-I LTR-env-pX transgenic rats : a prototype animal model for collagen vascular an HTLV-I-related inflammatory diseases"Pathobiology. 69. 11-18 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Sugaya T, Ishizu A, Ikeda H, Nakamaru Y, Fugo K, Higuchi M, Yamazaki H, Imai K, Yoshiki T: "Clonotypic analysis of T cells accumulating at arthritic lesions in HTLV-I env-pX transgenic rats"Exp Mol Pathol. 72. 56-61 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tsukamoto Y, Matsuo N, Zawa K, Hori O, Higashi T, Nishizaki J, Tohnai I, Kawano K, Yutani C, Hirota S, Kitamura Y, Stem DM, Ogawa S: "Expression of a novel RNA-splicing factor, RA301/Tra2β, in vascular lesions and its role in smooth muscle cell proliferation"Am J Pathol. 158. 1685-1694 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 鈴木淳子, 富田幸子, 中澤 誠, 小松敬子, 由谷親夫, 川瀬昌司, 大塚拓治, 川端健二: "川崎病血管炎の免疫組織化学的検討"Prog Med. 21. 1676-1678 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ikeda Y, Yonemitsu Y, Ishibashi T, Murata T, Ueno H, Kato A, Nagai Y, Fukumura M, Inomata H, Hasegawa M, Sueishi K: "Recombinant Sendai virus-mediated gene transfer to the retinal tissue of adult rats : efficient gene transfer by brief exposure"Exp Eye Res. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakashima Y, Chen Y-X, Kinukawa N, Sueishi K: "Distributions of diffuse intimal thickening in human arteries : prefential expression in atherosclerosis-prone arteries from an early age"Virchows Arch. (in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yonemitsu Y, Komori K, Sueishi K, Sugimachi K: "Gene therapy in vascular surgery comes of age"Surgery. 131. S261-S268 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Masaki I, Yonemitsu Y, Komori K, Ueno H, Nakashima Y, Nakagawa K, Fukumura M, Kato A, Hasan M, Nagai Y, Sugimachi K, Hasegawa M, Sueishi K: "Recombinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system"FASEB J. 15. 1294-1296 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Uzuki M, Sasano H, Muramatsu Y, Totsune K, Oki Y, Takahashi K, Iino K, Sawai T: "Urocortin in the synovial tissue of patients with rheumatoid arthritis"Clinical Science. 100. 577-589 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kurose A, Yoshida W, Yoshida M, Sawai T: "Effects of paclitaxel on cultured synovial cells from patients with rheumatoid arthritis"Cytometry. 44. 349-354 (2001)

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      2001 Annual Research Report
  • [Publications] Nakazawa F, Matsuno H, Yudoh K, Katayama R, Sawai T, Uzuki M, Kimura T: "Methotrexate inhibits rheumatoid synovitis by inducing apoptosis"J Rheumatol. 28. 1800-1808 (2001)

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      2001 Annual Research Report
  • [Publications] 澤井高志, 宇月美和, 柴田祐二, 岩崎真弓, 三宮彰仁, 藤川博康, 中島 洋: "生検像と臨床所見からHypereosinophilic Syndrome(HES)が疑われた症例"脈管学. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] 松本俊治, 福村由紀, 須田耕一: "膠原病における肝、胆管、膵の病理所見"胆と膵. 22. 397-402 (2001)

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      2001 Annual Research Report
  • [Publications] 神谷康司, 中林公正, 有村義宏, 長澤俊彦: "MPO-ANCA関連血管炎"日臨免会誌. 23. 661-664 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 有村義宏, 丸茂朋史, 藤井亜砂美, 中林公正, 長澤俊彦: "膠原病と自己抗体.抗好中球細胞質抗体(ANCA)-ELISAによるANCA測定-"臨床病理. 49. 571-574 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 中林公正, 神谷康司, 斉藤生朗: "膠原病関連大型血管炎の発症に関与する因子と治療法に関する臨床的解析"脈管学. 41. 397-401 (2001)

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      2001 Annual Research Report
  • [Publications] 神谷康司, 有村義宏, 中林公正: "血管炎における好中球の役割"Medicina. 38. 975-977 (2001)

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      2001 Annual Research Report
  • [Publications] Kitoh A, Nobuhara S, Takahashi K, Nishigori C, Miyachi Y: "Churg-Strauss syndrome with renal involvement : A case report"J Dermatol. 28. 71-74 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsumura Y, Tomimoto H, Yamamoto M, Imamura S, Miyachi Y: "Sneddon syndrome with multiple cerebral infarctions 12 years after the onset of Livedo vasculitis : A possible involvement of platelet activation"J Dermatol. 28. 508-510 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yamaoka J, Kabashima K, Kawanishi M, Toda KI, Miyachi Y: "Cytotoxicity of IFN-γ and TNF-α for vascular endothelial cell is mediated by nitric oxide"Biochem Biophys Res Commun. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Shimizu D, Fujiwara T, Kon K, Issiki N, Tsunokuni H: "Three-dimensional reconstruction by scanning electron microscopy from serial epoxy resin semi-thin sections after ion-etching"J Electr Microsc. 50. 51-55 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小林 靖, 沼野藤夫: "血管炎症候群-分子レベルの解析から臨床まで;高安動脈炎の病根と分子遺伝学的解析"日本内科学会雑誌. 90. 90-93 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kobayashi Y, Numano F: "Takayasu Arteritis"Internal Medicine. 41. 44-46 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hasegawa H, Fjita S: "Chemokines and lymphocytes : The role of chemokines and their receptors in the immune system"Cell Mol Biol. 47. 599-607 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nomura T, Hasegawa H, Kohno M, Fujita S: "Enhancement of anti-tumor immunity by tumor cells transfected with the secondary lymphoid tissue chemokine EBI-1-ligand chemokine and stromal cell-derived factor-1α chemokine genes"Int J Cancer. 91. 597-606 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 石津明洋, 吉木 敬: "血管炎のモデル動物.血管炎(長澤俊彦監修、橋本博史編集)"朝倉書店. 365 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 黒瀬 顕, 澤井高志: "血管炎における組織損傷機序.血管炎(長澤俊彦監修、橋本博史編集)"朝倉書店. 365 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松本俊治, 三田村美紀子: "病理形態的・免疫組織化学的診断.血管炎(長澤俊彦監修・橋本博史編集)"朝倉書店. 365 (2001)

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      2001 Annual Research Report
  • [Publications] 中林公正: "結節生多発動脈炎.血管炎(長澤俊彦監修、橋本博史編集)"朝倉書店. 365 (2001)

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      2001 Annual Research Report
  • [Publications] 宮地良樹: "血栓性静脈炎.皮膚疾患最新の治療(新村眞人、瀧川雅治編)"南江堂. (2001)

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      2001 Annual Research Report
  • [Publications] Nose M,Nishihara M,Kamogawa J,Terada M,Nakaturu S.: "Genetic basis of autoimmune disease in MRL/lpr mice : dissection of the complex pathological manifestations and their susceptibility loci."Immunogenetics. 2. 154-164 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nose M,Nishihara M,Fujii H: "Genetic basis of the complex pathological manifestations of collagen disease : Lessons from MRL/lpr and related mouse models."Int Rev Immunol. 19. 473-498 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nose M,Terada M,Nishihara M,Kamogawa J,Miyazaki T,Qu WM,Mori S,Nakatsuru S.: "Genome analysis of collagen disease in MRL/lpr mice : polygenic inheritance resulting in the complex pathological manifestations."Int J Cardiol. 75. S53-S61 (2000)

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      2000 Annual Research Report
  • [Publications] 能勢眞人: "膠原病の病像多様性・類似性の起源-モデルマウスに学ぶゲノム病理学"リウマチ. 40. 833-848 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ito MR,Terasaki S,Kondo E,Shiwaku H,Fukuoka Y,Nose M.: "Experimental lupus nephritis in severe combined immunodeficient (SCID) mice : remodeling of the glomerular lesions by bystanderIgM antibodies."Clin Exp Immunol. 119. 340-345 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Qu WM,Miyazaki T,Terada M,Lu LM,Nishihara M,Yamada A,Mori S,Nakamura Y,Ogasawara H,Yazawa C,Nakatsuru S,Nose M.: "Genetic dissection of vasculitis in MRL/lpr lupus mice : a novel susceptibility locus involving the CD72^c allele."Eur J Immunol. 30. 2027-2037 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 能勢眞人: "膠原病の病像多様性・類似性の起源-モデルマウスのゲノム解析によるアプローチ"日病会誌. 89. 41-59 (2000)

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      2000 Annual Research Report
  • [Publications] 石津明洋,吉木敬: "血管炎のモデル動物"最新医学. 55. 2611-2615 (2000)

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      2000 Annual Research Report
  • [Publications] Inder SJ,Bobryshev YV,Cherian SM,Wang AY,Lord RSA,Masuda K,Yutani C.: "Immunophenotypic analysis of the aortic wall in Takayasu's arteritis : involvement of lymphocytes, dendritic cells and granulocytes in immuno-inflammatory reactions."Cardiovas Surg. 8. 141-148 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Inder SJ,Bobryshev YV,Cherian SM,Lord RSA,Masuda K,Yutani C: "Accumulation of lymphocytes, dendritic cells, and granulocytes in the aortic wall affected by Takayasu's disease."Angiol. 51. 565-579 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Masaki I,Yonemitsu Y,Komori K,Ueno H,Nakashima Y,Nakagawa K,Fukumura M,Kato A,Hasan MK,Nagai Y,Sugimachi K,Hasegawa M,Sueishi K.: "Recombinant Sendai virus-mediated gene transfer to vasculature : a new class of efficient gene transfer vector to the vascular system."FASEB J. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Egashira K,Koyanagi M,Kitamoto S,Weihua N,Kataoka C,Morishita R,Kaneda Y,Akiyama C,Nishida K,Sueishi K,Takeshita K.: "Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats : blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthase."FASEB J. 14. 1974-1978 (2000)

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      2000 Annual Research Report
  • [Publications] Yoshikawa H,Ishibashi T,Hata Y,Inomata H,Sueishi K.: "The suppressive effect of tecogalan sodium on in vitro angiogenesis via the periendothelial proteolytic activities."Ophthalmic Res. 32. 261-269 (2000)

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      2000 Annual Research Report
  • [Publications] Nakagawa K,Chen Y-X,Ishibashi H,Yonemitsu Y,Murata T,Hata Y,Nakashima Y,Sueishi K.: "Angiogenesis and its regulation : roles of vascular endothelial cell growth factors."Semin Thromb Hemost. 26. 61-66 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ogishima D,Matsumoto T,Nakamura Y,Yoshida K,Kuwabara Y.: "Placental pathology in systemic lupus erythematosis with antiphospholipid antibodies."Pathol Int. 50. 224-229 (2000)

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      2000 Annual Research Report
  • [Publications] Matsumoto T,Kobayashi S,Shimizu H,Nakajima M,Watanabe S,Kitami N,Sato N,Abe H,Aoki Y,Hoshi T,Hashimoto H.: "The liver in collagen disease : Pathologic study of 160 cases with particlar reference to primary biliary cirrosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver."Liver. 20. 366-373 (2000)

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      2000 Annual Research Report
  • [Publications] Numano F,Kishi Y,Tanaka A,Ohkawara M,Kakuta T,Kobayashi Y.: "Inflammation and Atherosclerosis."Ann NY Acad Sci. 904. 65-76 (2000)

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      2000 Annual Research Report
  • [Publications] Numano F.: "Vasa vasoritis, vasculitis and Atherosclerosis."Int J Cardiol. 75. 1-8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kimura A,Ota M,Katsuyama Y,Ohbuchi N,Takahashi M,Kobayashi Y,Inoko H,Numano F.: "Mapping of the HLA-linked genes controlling the susceptibility to Takayasu's arteritis."Int J Cardiol. 75. 105-110 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Numano F,Okawara M,Inomata H,Kobayashi Y.: "Takayasu's arteritis."Lancet. 356. 1023-1025 (2000)

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      2000 Annual Research Report
  • [Publications] 沼野藤夫: "血管炎成因とその病態-特にvasa vasoritisの果たす役割について"脈管学. 40. 959-965 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakabayashi K,Kamiya Y,Nagasawa T.: "Aortitis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody ; report of three cases."Int J Cardiol. 75. S89-S94 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中林公正: "ANCA関連疾患の臨床"日内会誌. 89. 520-523 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Fujiwara T,Shimizu D,Kon K,Isshiki N,Tsunokuni H,and Aoyagi S: "A new method for detecting and localizing cell markers endocytosed by fibroblasts in epoxy resin semi-thin sections using scanning electron microscopy combined with energy dispersive X-ray microanalysis after ion-etching."J Electr Microsc. 49. 551-558 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu D,Fujiwara T,Kon K,Issiki N,Tsunokuni H: "Three-dimensional reconstruction by scanning electron microscopy from serial epoxy resin semi-thin sections after ion-etching."J Electr Microsc. 50(in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakatsuru S,Terada M,Nishihara M,Kamogawa J,Miyazaki T,Qu WM,Morimoto K,Yazawa C,Ogasawara H,Abe Y,Fukui K,Ichien G,Ito RM,Mori: "Genetic dissection of the complex pathological manifestataions of collagen disease in MRL/1pr mice."Pathol Int. 49. 974-982 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishihara M,Terada M,Kamogawa J,Ohashi Y,Mori S,Nakatsuru S,Nakamura Y,Nose M.: "Genetic basis of autoimmune sialoadenitis in MRL/1pr lupus mice:additive and hierarchical properties on polygenic inheritance."Arthritis Rheum. 42. 2616-2623 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nishihara H,Nose M,Hiai H,Minato N,Honjo T.: "Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor."Immunity. 11. 141-151 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ito MR,Terasaki S,Kondo E,Shiwaku H,Fukuoka Y,Nose M.: "Experimental lupus nephritis in severe combined immunodeficient (SCID)mice:remodelling of the glomerular lesions by bystander I"Clin Exp Immunol. 119(2). 340-345 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nose M,Terada M,Nishihara M,Kamogawa J,Miyazaki T,Qu W-M,Mori S,Nakatsuru S.: "Genome analysis of collagen disease in MRL/1pr mice:polygenic inheritance resulting in the complex pathological manifestations."Int J Cardiol. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Nose M,Nishihara M,Kamogawa J,Terada M,Nakatsuru S.: "Genetic basis of autoimmune disease in MRL/1pr mice:Dissection of the complex pathological manifestations and their susceptibil"Rev Immunogenet. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Nose M,Nishihara M,Fujii H.: "Lessons from MRL/1pr and related mouse models:Genetic basis of the complex pathological manifestations of collagen disease."Int Rev Immunol. (in press).

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakabayashi K,Kamiya Y,Nagasawa T.: "Aortitis syndrome associated with positive perinuclear antineutrophil cytoplasmic antibody."Int Cardiol. 68(in press). (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Katsumata K,Ikeda H,Sato M,Ishizu A,Kawarada Y,Kato H,Wakisaka A,Koike T,Yoshiki T.: "Cytokine regulation of env gene expression of human endogenous retrovirus-Rin human vascular endothelial cells."Clinical Immunol.. 93(1). 75-80 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Chen Y-X,Nakashima Y,Tanaka K,Shiraishi S,Nakagawa K,Sueishi K: "Immunohistochemical expression of vascular endothelial growth factor(VEGF)/vascular permeability factor(VPG) in the atheroscler"Arterioscler Thromb Vasc Biol. 19(1). 131-139 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Iwamoto H,Kiyohara Y,Fujishima M,Kato I,Nakayama K,Sueishi K,Tsuneyoshi M.: "Prevalence of Intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy scries during a 30-year ob"Stroke. 30. 1390-1395 (1999)

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      1999 Annual Research Report
  • [Publications] Watanabe N,Akikusa B,Park SY,Ohno H,Fassati L,Vecchietti G,Gessner JE,Schmidt RE,Verbeek JS,Ryffel B,Izui S,Saito T.: "Mast cells induce autoantibody-mediated vasculitis syndrome through tumor necrosis factor production upon triggering Fcr recept"Blood. 94(11). 3855-3863 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Uzuki M,Watanabe T,Katsura Y,Sawai T.: "Quantiative histochemical study of Hyalurinic acid binding protein and the activity of uridine diphosphoglucise dehydrogenase i"Anal Quant Cytol Histol. 21. 75-80 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Watanabe M,Sawai T.: "Alteration of cross-Linking amino acids of elastin in human aorta in association with dissecting aneurysm:analysis using high p"Tohoku Exp Med. 187. 291-303 (1999)

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      1999 Annual Research Report
  • [Publications] Watanabe M,Takahashi M,Sawai T.: "Unusual renal involvement of polymyositis complicated with malignant hypertension."Jap J Rheum.. 9. 381-390 (1999)

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      1999 Annual Research Report
  • [Publications] Kurose A,Oyama K,Murakami Y,Ohyama K,Segawa I,Sawai T.: "Dilated cardiomyopathy in Noonan syndrome:A first autopsy case."Human Pathology.(in press). (1999)

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      1999 Annual Research Report
  • [Publications] Ito M,Matsunaga K,Sano K,Sakaguchi N,Hotchi M.: "Intravascular fasciitis of the forearm vein:a case report with immunohistochemical characterization."Pathol Int. 49(2). 175-179 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kitamura H,Kitamura H,Ito S,Kuwana N,Yutani C: "Epithelioid hemangioma of the temporal artery clinically mimicking temporal arteritis"Pathol Int. 49. 831-835 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ishibashi-Ueda H,Yutani C,Kuribayashi S,Takamiya M,Imakita M,Ando M.: "Late in-stent restenosis of the abdominal aorta in a patioent with Takayasu's arteritis and related pathology."Cardio Vascular & Interventional Radiology. 22. 333-336 (1999)

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      1999 Annual Research Report
  • [Publications] Yamada K,Sugimoto K,Matsumoto T,Narumi K,Oshimi K.: "All-trans retinoic acid-induced vasculitis and hemonecrosis of the ileum in a patient with acute promyelocytic leukemia."Leukemia. 13(4). 647-648 (1999)

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  • [Publications] Ogishima D,Matsumoto T,Nakamura Y,Yoshida K,Kuwabara Y.: "Placental pathology in systemic lupus erythematosus with antiphospholipid antibodies."Pathol Int(in press).

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  • [Publications] Numano F.: "Vasovasoritis,vasculitis and artherosclerosis"Int.J.Card(in press). (2000)

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  • [Publications] Baba T,Itakura K,Tanaka R,Kawasaki I,Kiyosawa M,Numano F.: "Importance of fluorescein angiographic study in a evaluating early rental chances in Takayasu disease."Jpn Opthalmol. 43. 546-552 (1999)

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  • [Publications] Numano F,Gimbrone M.: "Inflammation and atherosclerosis"Atherosclerosis. V. (1999)

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  • [Publications] Ishikawa O,Takahashi A,Tamura A,Miyachi Y.: "Cutaneous papules and nodules in the diagnosis of the antiphospholipid syndrome."Br J Dermatol. 140. 725-729 (1999)

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  • [Publications] Ishikawa O,Abe M,i Miyachi Y.: "Herpes zoster in Japanese patients with systemic lupus eruthematosus."Clin Exp Dermatol. 24. 327-328 (1999)

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  • [Publications] Kurosawa M,Inamura H,Amano H,Kanbe N,Nagata H,Furukawa,S,Miyachi Y.: "Nerve growth factor release with mast cell derived mediators in a patient with systemic mastocytosis after middle-wave ultravio"Allergy. 54. 994-998 (1999)

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  • [Publications] 伊藤美津子,小野寺健,阿部弘之,三浦正悦,能勢眞人: "バルサルバ洞動脈瘤破裂に伴う大動脈弁断列にて急死した大動脈炎の一部検例"リウマチ. 39. 853-859 (1999)

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  • [Publications] 能勢眞人: "血管炎の遺伝要因-モデルマウスのゲノム解析-"治療学. 33. 152-156 (1999)

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  • [Publications] 能勢眞人: "血管炎モデルマウスのゲノム解析。"Bio Clinica. 14. 320-322 (1999)

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  • [Publications] 能勢眞人: "自然発症疾患モデル動物:血管炎。"Molecular Medicine. 36. 32-36 (1999)

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  • [Publications] 澤井高志,宇月美和: "リウマチの病理-動物モデルの病態解明と治療への応用-"病理と臨床(臨時増刊号・日本人の病気と病理学). 17. 321 (1999)

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  • [Publications] 渡辺徹雄、澤井高志、佐藤 成、宇月 美和、里見 進: "腹部大動脈瘤におけるMatrix metalloproteinase の役割。"脈管学(in press). 40. (2000)

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  • [Publications] 三浦康宏、黒瀬 顕、吉田浩子、井上洋西、澤井高志: "c-ANCAの低下とともに全身状態の悪化を示し、び慢性肺胞障害(DAD)で死亡したWegener肉芽腫症の一症例。"臨床リウマチ. (in press). (2000)

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  • [Publications] 沼野藤夫: "高安動脈炎"治療学. 33.2. 59-62 (1999)

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  • [Publications] 沼野藤夫: "血管炎における外膜の役割"血管と内皮. 9/3. 256-261 (1999)

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  • [Publications] 中林公正(分担): "内科学(全身性血管炎の項)"分光堂(黒川清,松澤佑次,他編). (1999)

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  • [Publications] 中林公正(分担): "わかりやすい内科学(ウェジナー肉芽腫症の項)"分光堂(井村裕夫,他編). (1999)

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  • [Publications] Numano F.(分担): "Takayasu Arteritis:Fouth edition of the Oxford,Text Book of Medicine"Edited by D.Warrell,T.M.Cox,J.D.Firth.Oxford Univ.Press. (2000)

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  • [Publications] Numano F.(分担): "Takayasu Arteritis,inflammatory disease of blood vessel"Edited by G.Hoffmann. (2000)

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      1999 Annual Research Report
  • [Publications] Numano F.(分担): "Takayasu Arteritis,vascular manifestation of systeming autoimmune disease"Edited by Atheson R-Cervera et al CRC Press. (2000)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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