| Co-Investigator(Kenkyū-buntansha) |
MIYACHI Yoshiki Kyoto Univ., Grad. Sch. Med., Dermatol., Prof., 大学院・医学研究科, 教授 (30127146)
SUEISHI Katsuo Kyushu Univ., Sch. Med,, Pathol., Prof., 大学院・医学研究院・医学部, 教授 (70108710)
YOSHIKI Takashi Hokkaido Univ., Sch. Med., Pathol., Prof., 医学部, 教授 (60220612)
NAKAHAYASHI Kimimasa Kyorin Univ., Sch. Med., Intern. Med., Prof., 医学部, 教授 (90086603)
YUTANI Chikao National Cardiovascular Center, Pathol. Chief., 臨床検査部, 部長
沼野 藤夫 東京医科歯科大学, 医学部, 教授 (40013958)
油谷 親夫 国立循環器病センター, 臨床検査部, 部長
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| Budget Amount *help |
¥40,590,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2001: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2000: ¥10,500,000 (Direct Cost: ¥10,500,000)
Fiscal Year 1999: ¥14,100,000 (Direct Cost: ¥14,100,000)
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| Research Abstract |
Recent advances in vascular cell biology may make it possible to clarify the molecular mechanisms and pathomorphological bases of vasculitis syndromes. We thus performed several projects to take a new turn as follows.
1 Molecular pathological analyses of the phenotypic expression of vascular cells: 1) cross talks among cells and molecules in vasculitis (adhesion molecules, histamine, NO, apoptosis, vascular remodeling), 2) angiogenesis (gene expression, FGF-2/VEGF, a new differentiation pathway of endothelial cells, three dimensional analysis), 3) pathomorphological features specific for diseases (IAAA, pulmonary plexiform angiopathy, Takayasu arteritis, MPA, intra-hepatic vasculitis in collagen disease, arteriosclerosis, vasa-vasoritis),
2 Affecting and modifying host factors in vascular injury: 1) ANCA (mechanisms of vascular injury, tissue distribution of vasculitis, regular variations of glomerular lesions, Takayasu arteritis), 2) serum factors (anti-endothelial cell antibodies, rheu
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matoid factors, anti-phospholipid syndrome, antibodies phagocytizable by endothelial cells), 3) T cell clonalities (GCA, pathophysiological dymanics, Takayasu arteritis, arteriosclerosis), 4) lysosomal enzymes (Kawasaki disease),
3 Animal models for vasculitis: 1) Kawasaki disease (C.albicans extract-induced vasculitis, MPO- knock out mice), 2) Virus-dependent vasculitis (HTLV-1 env-pX transgenic rat, HCMV-IE transgenic mice), 3) MRL mice for vasculitis in collagen disease (inhibition by IRF-1 trans gene and gene transfer of chemokine antagonist),
4 Genome analysis: 1) Takayasu arteritis (HLA polymorphism, SNP of lKBL1), 2) geographical pathology (Takayasu arteritis), 3) MRL mouse vasculitis (positional candidate genes, blood vessel-caliber specific gene loci, 35 recombinat inbred strains for vasculitis research), 4) Kawasaki disease model mice (vasculitis-resistant loci),
5 Extramural seminars: 1) "International Workshop on Systemic Vasculitis 2000", Tokyo, Oct. 14, 2000, 2) "New Developments in Vasculitis Research", Matsuyama, Feb. 16, 2002. Less
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