| Project/Area Number |
11307020
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A).
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
OGAWA Michio Kumamoto University School of Medicine Professor, 医学部, 教授 (30028691)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HIROTA Masahiko Kumamoto University School of Medicine, Assistant, 医学部・附属病院, 助手 (80284769)
MORI Katsutaka Kumamoto University College of Medical Science Professor, 医療技術短期大学部, 教授 (10040213)
山口 康雄 熊本大学, 医学部, 助教授 (90253757)
|
|---|
| Project Period (FY) |
1999 – 2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥21,200,000 (Direct Cost: ¥21,200,000)
Fiscal Year 2000: ¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 1999: ¥15,300,000 (Direct Cost: ¥15,300,000)
|
|---|
| Keywords | acute pancreatitis / SIRS / CARS / organ dysfunction / infection / cytokine / サイトカイン / 好中球 / エンドトキシン / メディエータ / 易感染性 / サイトカイン拮抗物質 / second attack |
|---|
| Research Abstract |
Acute pancreatitis is a potentially fatal disease. Most patients develop systemic inflammatory response syndrome (SIRS), which is induced by inflammatory cytokines. In this condition, neutrophils primed by preceding inflammatory insult are further activated to cause distant organ dysfunction if the second attack-like infection occurs. Alternatively, patients with severe inflammatory insults also undergo an anti-inflammatory phase, the compensatory anti-inflammatory response syndrome (CARS). This condition is characterized by the production of anti-inflammatory cytokines and, as a result, suppression of cytokine response, which may result in immune suppression. After induction of severe pancreatitis, cytokine production was markedly suppressed for a while. In this CARS condition, production of IL-2 by splenocyte decreased and mortality rate after induction of bacterial peritonitis increased. These results suggest that both excessive cytokine response in SIRS and altered defense system in CARS may result in the development of distant organ dysfunction.
|
