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CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPY

Research Project

Project/Area Number 11307025
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionKUMAMOTO UNIVERSITY

Principal Investigator

USHIO Yukitaka  KUMAMOTO MEDICAL DEPARTMENT, KUMAMOTO UNIVERSITY, PROFESSOR, 医学部, 教授 (20028583)

Co-Investigator(Kenkyū-buntansha) KOCHI Masato  KUMAMOTO MEDICAL DEPARTMENT, KUMAMOTO UNIVERSITY, ASSOCIATE PROFESSOR, 医学部, 助教授 (70178218)
SAYA Hideyuki  KUMAMOTO MEDICAL DEPARTMENT, KUMAMOTO UNIVERSITY, PROFESSOR, 医学部, 教授 (80264282)
西 徹  熊本大学, 医学部・附属病院, 助手 (00264309)
竹島 秀雄  熊本大学, 医学部, 助手 (70244134)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥39,220,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2001: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Fiscal Year 2000: ¥7,400,000 (Direct Cost: ¥7,400,000)
Fiscal Year 1999: ¥23,500,000 (Direct Cost: ¥23,500,000)
Keywordsmalignant glioma / gene analysis / p53 / p16 / EGFR / LOH 10 / prognosis / classification / glioblastoma / グリオーマ / 10番染色体 / LOH / PTEN / 生存日数 / 機能的解析
Research Abstract

To establish rational therapy for malignant gliomas (MG) based on their genetic background, we performed molecular genetic analysis to determine factors related to the initiation and progression of these tumors. We studied p53 mutation(s), p16 homozygous deletions) (HD), the amplification of epidermal growth factor receptor (EGFR), and, loss of heterozygosity, (LOH) for chromosome 10.
Our samples consisted of 15 pilocytic astrocytomas (PA), 20 diffuse astrocytomas (A), 55 anaplastic astrocytomas (AA), and 135 glioblastomas multiforme (GBM).
In PA, there were no genetic abnormalities except in special cases associated with neurofibromatosis-1. Mutation of p53 was observed in 29 % of A, 50 % of AA, and 35 % of GBM. HD of p16 was observed in 10 % of AA and 31 % of GBM; 9 % of AA and 31 % of GBM manifested EGFR amplification; 36 % of AA and 63 % of GBM had LOH for chromosome 10. We found that LOH for chromosome 10, especially the PTEN locus, was an unfavorable prognostic factor in patient with GBM (Tada K, et al: J. Neurosurg. 95, 2001), and that HD of p16 was also an unfavorable prognostic factor in male GBM patients (Kamiryo T, et al: J. Neurosurg. (in press), 2002).
Based on analysis of the 4 genetic alterations, we classified MG into 7 subtypes. The combination of EGFR amplification and LOH for chromosome 10 was the most unfavorable prognostic indicator in patient with GBM. We conclude that it is necessary to develop novel therapies, for example gene therapy, to treat such patients with MG.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (98 results)

All Other

All Publications (98 results)

  • [Publications] Y.Ushio: "Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinoma"J. Neurosurg.. 90. 133-137 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Nishi: "Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma"International Journal of Molecular Medicine. 3. 157-161 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Sato: "Expression of p120 nucleolar proliferating antigen in human gliomas and growth suppression of glioma cells by p120 ribozyme vector"Int. J. Oncology. 14. 417-424 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yamamoto: "Cloning and Functional Characterization of the 5'-Flanking Region of the Human Monocyte Chemoattractant Protein-1 Receptor (CCR2) Gene"The Journal of Biological Chemistry. 274. 4646-4654 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Takeshima: "Cerebral Gumma Showing Spontaneous Regression on Magnetic Resonance Imaging Study-Case Report-"Neurol. Med. Chir. 39. 242-245 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Kuratsu: "A phase II study of KRN8602 (MX2), a novel morpholino anthracycline derivative, in patients with recurrent malignant glioma"J. Neuro-Oncol.. 42. 177-181 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Sugahara: "Perfusion-Sensitive MRI of Cerebral Lymphomas : A preliminary Report"J. Comput. Assist. Tomogr.. 23. 232-237 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Sugahara: "Usefulness of Diffusion-Weighted MRI With Echo-Planar Technique in the Evaluation of Cellularity in Gliomas"Journal of Magnetic Resonance Imaging. 9. 53-60 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Saito: "Induction of apoptosis by N-(4-hydroxyphenyl) retinamide in glioma cells"International Journal of Oncology. 15. 499-504 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Nishi: "Tissue Factor Expressed in Pituitary Adenoma Cells Contributes to the Development of Vascular Events in Pituitary Adenomas"Cancer. 86. 1354-1361 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Kochi: "High-dose chemotherapy with autologus hematopoietic stem-cell rescue for patients with malignant brain tumors"Crit. Rev. Neurosurgery. 9. 295-302 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Tsuiki: "A Novel Human Nucleoside Diphoshate (NDP) Kinase, Nm23-H6, Localizes in Mitochondria and Affects Cytokinesis"J. Cellular Biochemistry. 76. 254-269 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Takeshima: "Monocyte chemoattractant protein-1(MCP-1) derived from human malignant glioma-biological meaning of its expression and application for the treatment of malignant glioma"Current Trends in Immunology. 2. 187-194 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Goto: "Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene"Proceedings of the National Academy of Sciences of the United States of America. 97. 354-359 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Nishi: "Reporter/Functional Gene Transfer in Rat Brain"Methods in Molecular Medicine. 37. 339-348 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yoshizato: "Gene delivery with optimized electroporation parameters shows potential for treatment of gliomas"International Journal of Oncology. 16. 899-605 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Kuratsu: "Incidence and clinical features of asymptomatic meningiomas"J. Neurosurg.. 92. 766-770 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Sugahara: "Posttherapeutic Intraaxial Brain Tumor : The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue"Am J. Neuroradiol.. 21. 901-909 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Takeshima: "Suppression of the tissue factor-dependent coagulation cascade : Acontributing factor for the development of intratumoral hemorrhage in glioblastoma"International Journal of Molecular Medicine. 6. 271-276 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Kuratsu: "Phase II trial of pre-irradiation KRN8602(MX2) in malignant glioma patients"J. Neuro-Oncology. 48. 145-149 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Kochi: "Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma"J. Neuro-Oncology. 49. 63-70 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "Spinal seeding of anaplastic ependymoma mimicking fungal meningitis A case report and review of the literature"J. Neurosurgical Sciences. 44. 46-52 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yamada: "Diffuse Brainstem Glioma in a Patient with Laurence-Moon-(Bardet-) Biedl Syndrome"Pediatr. Neurosurg.. 33. 323-327 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yamada: "Symptomatic solitary xanthogranuloma occupying the cavernous sinus"J. Neurosurg. 94. 322-326 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Takeshima: "Metastatic Brain Tumours from Oesophageal Carcinoma : Neuro-Imaging and Clinicopathological Characteristics in Japanese Patients"Acta Neurochir (Wien). 143. 31-36 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "The invasive features of glial and non-central nervous system tumor cells are different on organotypic brain slices from newborn rats"International J. Oncology. 18. 721-727 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Tsuiki: "Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines"Oncogene. 20. 420-429 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Murakami: "The inhibitory effect of simvastatin on growth in malignant gliomas-with special reference to its local application with fibrin glue spray in vivo"International Journal of Oncology. 19. 525-531 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Kuratsu: "Trends in the incidence of primary intracranial tumors in Kumamoto, Japan"Int. J. Clin. Oncol.. 6. 183-191 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Koga: "Expression of Angiopoietin-2 in Human Glioma Cells and its Role for Angiogenesis"Cancer Research. 61. 6248-6254 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Tada: "Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors : correlation with patient age and survival"J. Neurosurg.. 95. 651-659 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Kino: "Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma"Genes to Cells. 6. 441-434 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Goto: "Suprasellar Hemangioblastoma in a patient with von hippel-lindau disease confirmed by germline mutation study. case report and review of the literature"Surgical Neurology. 56. 22-26 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Kai: "Appropriate Interval between Embolization and Surgery in Patients with Meningioma"Am. J. Neuroradiol.. 23. 139-142 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Kamiryo: "Analysis of Homozygous Deletion of p16 Gene in Patients with Glioblastoma and its correlation with Patient Survival"J. Neurosurg.. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Shiraishi: "Influence of p53 Mutations on Prognosis of Patients with Glioblastoma"Cancer. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Ushio: "Preliminary observations for a new treatment in children with primary intracranial yolk sac tumor or embryonal carcinom"J. Neurosurg.. 90. 133-137 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Nishi: "Prognostic significance of the MIB-1 labeling index for patient with craniopharyngioma"International Journal of Molecular Medicine. 3. 157-161 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Sato: "Expression of p120 nucleolar proliferating antigen in human gliomas and growth suppression of glioma cells by p120 ribozyme vector"Int. J. Oncology. 417-424 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yamamoto: "Cloning and Functional Characterization of the 5'-Ranking Region of the Human Monocyte Chemoattractant Protein-1 Receptor (CCR2) Gene"The Journal of Biological Chemistry. 274. 4646-4654 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Takeshima: "Cerebral Gumma Showing Spontaneous Regression on Magnetic Resonance Imaging Study - Case Report -"Neural. Med. Chir.. 39. 242-245 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Kuratsu: "A phase II study of KRN8602 (MX2), a novel morpholino anthracycline derivative, in patients with recurrent malignant glioma"J. Neuro-Oncol.. 42. 177-181 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Sugahara: "Perfusion-Sensitive MRI of Cerebral Lymphomas: A preliminary Report"J. Comput. Assist. Tomogr.. 23. 232-237 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Sugahara: "Usefulness of Diffusion-Weighted MRI With Echo-Planar Technique in the Evaluation of Cellularity in Gliomas"Journal of Magnetic Resonance Imaging. 9. 53-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Saito: "Induction of apoptosis by N-(4-hydroxyphenyl ) retinamide in glioma cells"International Journal of Oncology. 15. 499-504 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Nishi: "Tissue Factor Expressed in Pituitary Adenoma Cells Contributes to the Development of Vascular Events in Pituitary Adenomas"Cancer. 86. 1354-1361 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kochi: "High-dose chemotherapy with autologus hematopoietic stem-cell rescue for patients with malignant brain tumors"Crit. Rev. Neurosurgery. 9. 295-302 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Tsuiki: "A Novel Human Nucleoside Diphoshate (NDP) Kinase, Nm23-H6, Localizes in Mitochondria and Affects Cytokinesis"J. Cellular Biochemistry. 76. 254-269 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Takeshima: "Monocyte chemoattractant protein- 1 (MCP-1) derived from human malignant glioma-biological meaning of its expression and application for the treatment of malignant glioma"Current Trends in Immunolog. 2. 187-194 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Goto: "Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidin kinase gene"Proceedings of the National Academy of Sciences of the United States of America. 97. 354-359 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Nishi: "Reporter / Functional Gene Transfer in Rat Brain"Methods in Molecular Medicine. 37. 339-348 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yoshizato: "Gene delivery with optimized electroporation parameters shows potential for treatment of gliomas"International Journal of Oncology. 16. 899-905 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Kuratsu: "Incidence and clinical features of asymptomatic meningiomas"J. Neurosurg.. 92. 766-770 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Sugahara: "Posttherapeutic Intraaxial Brain Tumor: The Value of Perfuston-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue"Am J. Neuroradiol.. 21. 901-909 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Takeshima: "Suppression of the tissue factor-dependent coagulation cascade: Acontributing factor for the development of intratumoral hemorrhage in glioblastoma"International Journal of Molecular Medicines, 6.. 271-276 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Kuratsu: "Phase II trial of pre-irradiation KRN8602 (MX2) in malignant glioma patients"J. Neuro-OncoIogy. 48. 145-149 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kochi: "Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma"J. Neuro-OncoIogy. 49. 63-70 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Murakami: "Spinal seeding of anaplastic ependymoma mimicking fungal meningitis A case report and review of the literature"J. Neurosurgical Sciences. 44. 46-52 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yamada: "Diffuse Brainstem Glioma in a Patient with Laurence-Moon-(Bardet-)Biedl Syndrom"Pediatr. Neurosurg.. 33. 323-327 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Yamada: "Symptomatic solitary xanthogranuloma occupying the cavernous sinus"J. Neurosurg.. 94. 322-326 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Takeshima: "Metastatic Brain Tumours from Oesophageal Carcinoma: Neuro-Imaging and Clinicopathological Characteristics in Japanese Patients"Acta Neurochir. (Wien). 143. 31-36 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Murakami: "The invasive features ofglial and non-central nervous system tumor cells are different on organotypic brain slices from newborn rats"International J. Oncology. 18. 721-727 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Tsuiki: "Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell line"Oncogene.. 20. 420-429 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Murakami: "The inhibitory effect of simvastatin on growth in malignant gliomas-with special reference to its local application with fibrin glue spray in vivo"International Journal of Oncology. 19. 525-531 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Kuratsu: "Trends in the incidence of primary intracranial tumors in Kumamoto, Japan"Int. J. Clin. Oncol.. 6. 183-191 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Koga: "Expression of Angiopoietin-2 in Human Glioma Cells and its Role for Angiogenesis"Cancer Research. 61. 6248-6254 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Tada: "Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors: correlation with patient age and survival"J. Neurosurg.. 95. 651-659 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Kino: "Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylationdependent silencing in schwannoma"Genes to Cells. 6. 441-454 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Goto: "Suprasellar Hemangioblastoma in a patient with von hippel-lindau disease confirmed by germline mutation study. casereportand review of the literature"Surgical Neurology. 56. 22-26 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Kai: "Appropriate Interval between Embolization and Surgery in Patients with Meningioma"Am. J. Neuroradiol.. 23. 139-142 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Kamiryo: "Analysis of Homozygous Deletion of p16 Gene in Patients with Glioblastoma and its correlation with Patient Survival"J. Neurosurg.. (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Shiraishi: "Influence of p53 Mutations on Prognosis of Patients with Glioblastoma"Cancer. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Yamada, Y.Ushio: "Symptomatic solitary xanthogranuloma occupying the cavernous sinus"J.Neurosurg.. 94. 322-326 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] H.Takeshima, Y.Ushio: "Metastatic Brain Tumours from Oesophageal Carcinoma : Neuro-Imaging and Clinicopathological Characteristics in Japanese Patients"Acta Neurochir (Wien). 143. 31-36 (2001)

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  • [Publications] M.Murakami, Y.Ushio: "The invasive features of glial and non-central nervous system tumor cells are different on organotypic brain slices from newborn rats"International J.Oncology. 18. 721-727 (2001)

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      2001 Annual Research Report
  • [Publications] H.Tsuiki, Y.Ushio, H.saya: "Mechanism of hyperploid cell formation induced by microtubule inhibiting drug in glioma cell lines"Oncogene. 20. 420-429 (2001)

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      2001 Annual Research Report
  • [Publications] M.Murakami, M.Kochi, Y.Ushio: "The inhibitory effect of simvastatin on growth in malignant gliomas-with special reference to its local application with fibrin glue spray in vivo"International J.Oncology. 19. 525-531 (2001)

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  • [Publications] J.Kuratsu, Y.Ushio: "Trends in the incidence of primary intracranial tumors in Kumamoto, Japan"Int.J.Clin.Oncol.. 6. 183-191 (2001)

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      2001 Annual Research Report
  • [Publications] K.Koga, Y.Ushio: "Expression of Angiopoietin-2 in Human Glioma Cells and Its Role for Angiogenesis"Cancer Research. 61. 6248-6254 (2001)

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      2001 Annual Research Report
  • [Publications] K.Tada, M.Kochi, Y.Ushio: "Analysis of loss of heterozygosity on chromosome 10 in patients with malignant astrocytic tumors : correlation with patients age and survival"J.Neurosurg.. 95. 651-659 (2001)

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      2001 Annual Research Report
  • [Publications] T.Kino, M.Kochi, Y.Ushio: "Identification of the cis-acting region in the NF2 gene promoter as a potential target for mutation and methylation-dependent silencing in schwannoma"Genes to Cells. 6. 441-454 (2001)

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  • [Publications] T.Goto, M.Kochi, Y.Ushio: "Suprasellar Hemangioblastoma in a patient with von hippel-lindau disease confirmed by germline mutation study. case report and review of the literature"Surgical Neurology. 56. 22-26 (2001)

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  • [Publications] T.Tamura, Y.Ushio: "Intratumoral Delivery of Interleukin 12 Expression Plasmids with In Vivo Electroporation Is Effective for Colon and Renall Cancer"Human Gene Therapy. 12. 1265-1276 (2001)

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  • [Publications] Y.Kai, Y.Ushio: "Appropriate Interval between Embolization and Surgery in Patients with Meningioma"Am.J.Neuroradiol.. 23. 139-142 (2002)

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  • [Publications] T.Kamiryo, M.Kochi, H.Saya, Y.Ushio: "Analysis of Homozygous Deletion of p16 Gene in Patients with Glioblastoma and its Correlation with Patient Survival"J.Neurosurg.. (in press). (2002)

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  • [Publications] S.Shiraishi, M.Kochi, H.Saya, Y.Ushio: "Influence of p53 Mutations on Prognosis of Patients with Glioblastoma"Cancer. (in press). (2002)

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  • [Publications] Jun-ichi Kuratsu: "Incidence and clinical features of asymptomatic meningiomas"Journal of Neurosurgery. 92. 766-770 (2000)

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  • [Publications] Toru Nishi: "Reporter/Functional Gene Transfer in Rat Brain."Methods in Molecular Medicine. 37. 339-348 (2000)

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      2000 Annual Research Report
  • [Publications] Kimio Yoshizato: "Gene delivery with optimized electroporation parameters shows potential for treatment of gliomas."International Journal of Oncology. 16. 899-905 (2000)

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  • [Publications] Tomoaki Goto: "Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene."Proceedings of the National Academy of Sciences of the United States of America. 97(1). 354-359 (2000)

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  • [Publications] Masato Kochi: "Randomized comparison of intra-arterial versus intravenous infusion of ACNU for newly diagnosed patients with glioblastoma."Journal of Neuro-Oncology. 49. 63-70 (2000)

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      2000 Annual Research Report
  • [Publications] Hideo Takeshima : "Suppression of the tissue factor-dependent coagulation cascade : A contributing factor for the development of intratumoral hemorrhage in glioblastoma."International Journal of Molecular Medicine. 6. 271-276 (2000)

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  • [Publications] Goto T: "Highly efficient electro-gene therapy of splid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene."Proc. Nati. Aca. Sci. U.S.A.. 97(1). 354-359 (2000)

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      1999 Annual Research Report
  • [Publications] Nishi T: "Tissue Factor Expression in Pituitary Adenoma Cells Contributes to the Development of Vasclar Events in Pituitary Adenomas."Cancer. 86. 1354-1361 (1999)

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      1999 Annual Research Report
  • [Publications] Nishiyama Y: "A Human homolog of Drosophila warts tumor suppressor, h-warts, localized to mitotic apparatus and specifically phosphorylated during mitosis."FFBS Lett. 459(2). 159-165 (1999)

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      1999 Annual Research Report
  • [Publications] Tsuiki H: "A Novel Human Nucleoside Diphoshate(NDP) Kinase, Nm23-H6, Localizes in Mitochondria and Affects Cytokinesis."J. Cellular Biochemistry. 76. 254-269 (1999)

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      1999 Annual Research Report
  • [Publications] Saito Y: "Induction of apoptosis by N-(4-hydroxyphenyl)retnamide in glioma cells."International Journal of Oncology. 15. 499-504 (1999)

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      1999 Annual Research Report
  • [Publications] Okamoto I: "Regulated CD44 cleavage under the control of protein kinase C, calcium influx, and the Rho family of small G proteins."J Biol Chem. 274(36). 25525-25534 (1999)

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Published: 1999-04-01   Modified: 2016-04-21  

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