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Comprehensive studies on the establishment of clinical cariology for systematic

Research Project

Project/Area Number 11307044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

IWAKU Masaaki  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (70013927)

Co-Investigator(Kenkyū-buntansha) FUKUSHIMA Masayoshi  NIIGATA UNIVERSITY, University Dental Hospital, Associate Professor, 歯学部・付属病院, 助教授 (30156773)
OKAMOTO Akira  NIIGATA UNIVERSITY, University Dental Hospital, Lecturer, 歯学部・付属病院, 講師 (10143786)
KOHICHI Kota  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (90018755)
KODAMA Linlin  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, As sistant, 大学院・医歯学総合研究科, 助手 (10272824)
YOSHIBA Kunihiko  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Assistant, 大学院・医歯学総合研究科, 助手 (30220718)
鮎川 幸雄  新潟大学, 歯学部, 助手 (00183145)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥27,260,000 (Direct Cost: ¥26,000,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2001: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2000: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 1999: ¥17,000,000 (Direct Cost: ¥17,000,000)
KeywordsDental caries / Clinical cariology / Risk factor / Fluoride-reteasingmaterials / Biofilm / Laser / Dentin / Pulp complex / Antigen presenting cells / う蝕 / 修復材料 / う蝕予防 / う蝕細菌 / ウ蝕予防 / ウ蝕細菌
Research Abstract

The aim of this study was to establish the clinical cariology for systematic management of dental caries.
The main results were as follows:
1. Pathology and diagnosis of caries process
(1) A Laser apparatus was proved to be useful for diagnostic method for caries.
(2) Localizational changes of antigen presenting cells after caries treatment were evaluated immunohistochemically. The results showed that they remained for a long time after treatment.
2. Caries as an infectious disease
(1) Genetic diversity was revealed in Pseudoramibacter alactolyticus that is frequently identified in carious dentin.
(2) To elucidate the structure and the function of bacterial biofilms, artificial biofilms were made in vitro. This model is useful for elucidating bacterial functions in biofilms, and also for estimating the bactericidal efficacy of antibacterial drugs in biofilms.
3. Caries treatment
(1) Application of Er:YAG laser for caries removal and cavity preparation was evaluated by morphological changes in the tooth hard tissue and pulpal responses.
(2) To elucidate the mechanisms of repair and regeneration of dentin/pulp complex after direct pulp capping and in the pulp of transplanted tooth were immunohistochemically observed. The results suggested the involvement of noncollagenous proteins in hard tissue formation.
(3) Efficiency of propylene glycol was revealed as vehicles for intracanal medicaments in the intractable root canal treatment.
4. Prevention of reinfection (secondary caries) after treatment
Fluoride-releasing materials for their acid resistance were evaluated. The results indicated the important enhancement of tooth structure acid resistance by fluoridate materials, suggesting their clinical usefulness.
5. Patient education, periodic recall examination and risk assessment Bacteriological evaluation of a new oral brush for dependent elderly revealed its effectiveness for removal of bacterial plaque and usefulness for clinical use.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (43 results)

All Other

All Publications (43 results)

  • [Publications] Kunihiko Yoshiba: "Differential expression of laminin-5 subunits during incisor and molar development in the mouse"International Journal of Developmental Biology. 44. 337-340 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr: "Changes in the mechanical properties and surface texture of compomer immersed in various media"Journal of Prosthetic Dentistry. 84. 444-452 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masayoshi Fukushima: "Teaching of posterior composite restorations in Japanese dental schools"International Dental Journal. 50. 407-411 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han: "WDX study of resin-dentin interface on wet vs. dry dentin"Dental Materials Journal. 19. 317-325 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr: "Effect of alcoholic and low-pH soft drinks on fluoride release from compomer"Journal of Esthetic Dentistry. 12. 97-104 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr: "Color stability of compomer after immersion in various media"Journal of Esthetic Dentistry. 12. 258-263 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han: "Study of the fluoridated adhesive resin cement--fluoride release, fluoride uptake and acid resistance of tooth structures"Dental Materials Journal. 20. 114-122 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shoji Takenaka: "Artifisial Pseudomonas aeruginosa biofilms and confocal laser scanning microscopic analysis"Journal of Infection and Chemotherapy. 7. 87-93 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr: "Evaluation of the surface roughness of compomer by laser scanning microscopy"Dental Materials Journal. 20. 172-180 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Zhu: "Influence of starvation and biofilm formation on acid resistance of Streptococcus mutans"Oral Microbiology and Immunology. 16. 24-27 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Zhu: "Extracellular polysaccharides do not inhibit the reaction between Streptococcus mutans and its specific inununoglobulin G (IgG) or penetration of the IgG through S. mutans biofilm"Oral Microbiology and Immunology. 16. 54-56 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han: "A Comparative Study of Fluoride-releasing Adhesive Resin Materials"Dental Materials Journal. 21(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimi Shigetani: "A Study of Cavity Preparation by Er: YAG Laser -Observation of Hard Tooth Structures by Laser Scanning Microscope and Examination of the Time necessary to Remove Caries"Dental Materials Journal. 21(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] E.V.Cruz: "A laboratory study of coronal microleakage using four temporary restorative materials"International Endodontic Journal. 35(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kunihiko Yoshiba et al: "Differential expression of laminin-5 subunits during incisor and molar development in the mouse"International Joupal of Developmental Biology. 44(3). 337-340 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr et al: "Changes in the mechanical properties and surface texture of compomer immersed in various media"Jeurnal of Prosthetic Dentistry. 84(4). 444-452 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Masayoshi Fukushima et al: "Teaching of posterior composite restorations in Japanese dental schools"International Dental Journal. 50(6). 407-411 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han et al: "WDX study of resin-dentin interface on wet vs. dry dentin"Dental Materials Journal. 19(3). 317-325 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr et al: "Effect of alcoholic and low-pH soft drinks on fluoride release from compomer"Journal of Esthete Dentistry. 12(2). 97-104 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr et al: "Color stability of compomer after immersion in various media"Journal of Eshtetric Dentistry. 12(5). 258-263 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han et al: "Study of the fluoridated adhesive resin cement-fluoride release, fluoride uptake and acid resistance of tooth structures"Dental Materials Journal. 20(1). 114-122 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shoji Takenaka et al: "Artifisial Pseudomonas aeruginosa biofilms and confocal laser scanning microscopic analysis"Journal of Infection and Chemotherapy. 7(2). 87-93 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr et al: "Evaluation of the surface roughness of compomer by laser scanning microscopy"Dental Materials Journal. 20(2). 172-180 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Zhu et al: "Influence of starvation and biofilm formation on acid resistance of Streptococcus mutans"Oral Microbiology and Immunology. 16(1). 24-27 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Zhu et al: "Extracellular polysaccharides do not inhibit the reaction between Streptococcus mutans and its specific immurioglobulin G (IgG) or penetration of the IgG through S. mutans biofilm"Oral Microbiology and Immunology. 16(1). 54-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Linlin Han et al: "A Comparative Study of Fluoride-releasing Adhesive Resin Materials"Dental Materials Journal. 21(1), (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yoshimi Shigetani et al: "A Studv of Cavitv Preparation by Er:YAG Laser -Observation of Hard Tooth Structures by Laser Scanning Microscope and Examination of the Time necessary to Remove Caries-"Dental materials Journal. 21(1), (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] E.V. Cruz et al: "A laooraiory siuuy of Coronal microleakage useing four temporary restorative materials"International Endodontic Journal. 35, (in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Neamat Abu-bakr: "Color stability of compomer after immersion in various media"Journal of Esthetic Dentistry. 12(5). 258-263 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Linlin Han: "Study of the fluoridated adhesive resin cement--fluoride release, fluoride uptake and acid resistance of tooth structures"Dental Materials Journal. 20(1). 114-122 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Shoji Takenaka: "Artifisial Pseudomonas aeruginosa biofilms and confocal laser scanning microscopic analysis"Journal of Infection and Chemotherapy. 7(2). 87-93 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Neamat Abu-bakr: "Evaluation of the surface roughness of compomer by laser scanning microscopy."Dental Materials Journal. 20(2). 172-180 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Zhu: "Influence of starvation and biofilm formation on acid resistance of Streptococcus mutans."Oral Microbiology and Immunoogy. 16(1). 24-27 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] M.Zhu: "Extracellular polysaccharides do not inhibit the reaction between Streptococcus mutans and its specific immunoglobulin G (IgG) or penetration of the IgG through S. mutans biofilm"Oral Microbiology and Immunology. 16(1). 54-56 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Linlin Han: "A Comparative Study of Fluoride-releasing Adhesive Resin Materials"Dental Materials Journal. 21(1)(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshimi Shigetani: "A Study Cavity Preparation by Er : YAG Laser -Observation of Hard Tooth Structures by Laser Scanning Microscope and Examination of the Time necessary to Remove Caries-"Dental Materials Journal. 21(1)(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] E.V. Cruz: "A laboratory study of coronal microleakage using four temporary restorative materials"International Endodontic Journal. 35(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Neamat,Abu-Baker: "Effect of Alcoholic & low pH soft drinks on the fluoride release from compomer"J.Esthetic Dent. 12・2. 97-104 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Linlin Han: "A WDX study of resin-dentin interface on wet vs.dry dentin"Dent.Mater.J.. 19・3. 317-325 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Neamat,Abu-Baker: "Changes in the mechanical properties and surface textrue of compomer immersed in various media"J.of Prosthetic Dent. 84・4. 444-452 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] S.Takenaka: "Artifical Pseudomonas aeruginosa Biofilms and the Confocal Laser Scanning Microscopic Analysis"J.Infect.and Chemot.. (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kuhihiko Yoshiba: "Differential expression of laminin-5 subunits during incisor and molar development in the mouse."Int J Develop Bio.. 44(3). 337-340 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] M.Fukushima: "Teaching of posterior composite restorations in Japanese dental schools"Int.Dent.J.. 50. 407-411 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-11-11  

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