| Project/Area Number |
11307051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
KOWASHI Yusuke Health Sciences University of Hokkaido, Periodontology and Endodontology, Professor, 歯学部, 教授 (60014338)
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| Co-Investigator(Kenkyū-buntansha) |
ABIKO Norimitsu Nihon University Matsudo, Biochemistry, Professor, 松戸・歯学部, 教授 (70050086)
NISHIHARA Tatsuji Kyushu Dental College, Oral Microbiology, Professor, 歯学部, 教授 (80192251)
KAWANAMI Masamitsu Hokkaido University, Periodontology, Professor, 歯学部, 教授 (10133761)
MIYAZAKI Hideo Niigata University, Periodontology, Professor, 歯学部, 教授 (00157629)
YOSHIE Hiromasa Niigata University, Periodontology, Professor, 歯学部, 教授 (20143787)
加藤 熙 (加藤 熈) 北海道大学, 歯学部, 教授 (60001020)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥39,160,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2001: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2000: ¥8,700,000 (Direct Cost: ¥8,700,000)
Fiscal Year 1999: ¥19,800,000 (Direct Cost: ¥19,800,000)
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| Keywords | Aging / Periodontitis / Perindontal tissue |
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| Research Abstract |
1. Changes in systemic status by aging :
1) Immunological function and periodontal status : FcγRIIIb-Na1 polymorphism was associated with the resistance to periodontitis (Miyazaki ＆ Yoshie), and serum IgG2 was higher in elder population with > 19 teeth (Nakashima).
2) Bone mineral density and periodontal status: Healthy periodontitum was considered to be important to maintain the bone density of the lumbar vertebra (Nitta).
3) Systemic disease and periodontal regeneration: GBR was also effective in the bone repair in older rat model (Ohta).
4) Periodontal regeneration: Bone formation in palatal sites by BMP was not affected by aging (Kawanami).
2. Changes in periodontal tissue and cells by aging :
1) Reaction of periodontal cells with periodontopathic bacteria : A. actinomycetemcomitans induced apoptotic cell death of murine alveolar macrophages (Kowashi ＆ Nishihara).
2) Collagen metabolism : Functional differences between elastin and fibrillin were observed in fibroblasts obtained from human gingiva and periodontal membrane (Yajima).
3) Changes in cell-biological functions: Radiation of low-power laser has effects on cell proliferation, inflammation, bone metabolism, and passive immunization with monoclonal antibodies was effective in animal model with periodontitis (Abiko).
4) Epithelial rests of Malassez in periodontal membrane : Epithelial rests of Malassez is considered to be involved in cementum repair (Ogawa).
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