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Roles of Tyrosine Phosphorylation in The Development and Plasticity of The Central Nervous System

Research Project

Project/Area Number 11308031
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionThe University of Tokyo

Principal Investigator

YAMAMOTO Tadashi  Institute of Medical Science, The University of Tokyo, Professor, 医科学研究所, 教授 (40134621)

Co-Investigator(Kenkyū-buntansha) FUJIMOTO Jiro  Institute of Medical Science, The University of Tokyo, Research Associate, 医科学研究所, 助手 (60282521)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥38,900,000 (Direct Cost: ¥36,800,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2001: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2000: ¥14,000,000 (Direct Cost: ¥14,000,000)
Fiscal Year 1999: ¥15,800,000 (Direct Cost: ¥15,800,000)
KeywordsNovel tyrosine kinases / Central nervous system / RT-PCR / in silico screening / Signal transduction / ALK / Lyn / Filter kinase assay / チロシンキナーゼ / チロシンフォスファターゼ / シナプス伝達 / 神経回路網 / NMDA受容体 / Srcファミリー / SSH法 / ERBB2 / LYN / フィルターキナーゼアッセイ
Research Abstract

We performed three types of studies that are (1) the search of the novel tyrosine kinases expressed in the central nervous system, (2) identification of proteins that are respectively involved in Lyn and ALK tyrosine kinases-mediated signaling pathways in the central nervous system, (3) characterization of a protein-tyrosine phosphatase PTPMEG that associates with ionotropic glutamate receptors. The followings are the summary of the study.
(1) By performing differential screening of RT-PCR products and in silico screening, we identified novel kinases that included the one termed BREK (brain enriched kinase). We also identified a homologue of BREK termed BREK2. BREK and BREK2 are similar to AATYK that has been reported to be a tyrosine kinase involved in regulation of apoptotic death of neurons. Unlike AATYK, both BREK and BREK2 are dual specificity kinases showing strong serine/threonine and weak tyrosine kinase activities. Expression of BREK is high in the central nervous system, such as in cerebral cortex and olfactory bulb. BREK becomes phosphorylated upon NGF stimulation of cultured neuronal cells, suggesting that BREK is involved in neurite extension.
(2) By employing filter kinase assay and yeast two-hybrid screening, we identified BANK and SNT2 as substrates of Lyn and ALK, respectively. BANK is an adaptor protein that links Lyn to IP_3 receptor (IP_3R). We showed that formation of Lyn/BANK/IP_3R resulted in tyrosine phosphorylation of IP_3R, which is known to upregulate the channel activity of IP_3R. Regarding SNT2, we showed that SNT2 was critically important for ALK-mediated signaling.
(3) We also identified various signaling molecules that were associated with ionotropic glutamate receptors. One of them is PTPMEG that associates with GluRd2 and NMDA receptor subunits NR2A. PTPMEG is expressed high in the thalamus and affects the level of tyrosine phosphorylation of NR2A, suggesting that PTPMEG is involved in controlling synaptic plasticity.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (92 results)

All Other

All Publications (92 results)

  • [Publications] H.Umemori: "Stimulation of Myelin Basic Protein Gene Transcription by Fyn Tyrosine Kinase for Myelination"J. Neuroscience. 19. 1393-1397 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Hayashi: "The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn"Nature. 397. 72-76 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Tsukamoto: "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40"Proc. Natl. Acad. Sci. USA. 96. 1234-1239 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Tezuka: "PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A"Proc. Natl. Acad. Sci. USA. 96. 435-440 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Narisawa-Saito: "Growth factor-mediated Fyn signaling regulates AMPA receptor expression in rodent neocortical neurons"Proc. Natl. Acad. Sci. USA. 96. 2461-2466 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A.Naito: "Severe osteopetrosis, devective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice"Genes Cells. 4. 353-362 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Horikawa: "Distinctive roles of Fyn and Lyn in IgD-and IgM-magma-Mediated signaling"Int'l Immunol.. 11. 1441-1449 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Ikematsu: "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases"Oncogene. 18. 7432-7441 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Kim: "Molecular cloning and characterization of a novel cbl-family gene, cbl-c"Gene. 239. 145-154 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H.Umemori: "Involvement of protein tyrosine phosphatase in activation of the trimeric G protein G_<q/11>"Oncogene. 18. 7399-7402 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Muto: "Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalophathy"Neuroscience Letters. 271. 69-72 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C.Hisatsune: "Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor ω2 subunit with phosphatidylinositol 3-kinase"Genes Cells. 4. 657-666 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] D.J.Caughey: "Fractionation of polyclonal antibodies to fragments of a neuroeceptor using three increasingly chaotropic solvents"J. Chromatogr. B. Biomed. Sci. Appl.. 728. 49-57 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Fujimoto: "Cloning and characterization of dfak56, a homolog of focal adhesion kinase, in drosophila melanogaster"Biol. Chem.. 274. 29196-29201 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M.Martins-Green: "Tissue specific expression of Yrk kinase : implications for differentiation and inflammation"Int'l. J. Biochem. and Cell Biol.. 32. 351-364 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Yamanashi: "Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling"Genes & Dev.. 14. 11-16 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Yasuda: "Cbl suppresses B cell receptor-mediated phospholipase c-γ2 activation by regulating BLNK-PLC-γ2 binding"J. Exp. Med.. 191. 641-650 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Z.Honda: "Sequential requirements of the N-Terminal palmitoylation site and SH2 comain of Src family kinases in the initiation and progression of FcεRi signaling"Mol. Cel. Biol.. 20. 1759-1771 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J.Inoue: "Tumor necrosis factor receptor-associated factor (TRAF) family : adapter proteins that mediated cytokine signaling"Exp. Cell Res.. 254. 14-24 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.M.Sharma: "Aurine Tricarboxylic Acid, a potent metal-chelating inhibitor of NFkB-DNA binding. Bioorg"Bioorg. Med. Chem.. 165. 473-482 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Suzuki: "Differential involvement of Src family kinases in Fcy receptor-mediated phagocytosis"J. Immunol.. 165. 473-482 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K.Hironaka: "The protein-tyrosine phosphatase PTPMEG interacts glutamate-receptor delta 2 and epsilon subunits"J. Biol. Chem.. 275. 16167-16173 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] R.Ajima: "Cloning and characterization of the mouse tob2 gene"Gene. 253. 215-220 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Sein: "A role of FAK in the concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9"Oncogene. 19. 5539-5542 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Yoshida: "Negative regulation of BMP/Smad signaling by Tob in osteoblasts"Cell. 103. 1085-1097 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S.Miki: "Reduction of artherosclerosis despite hypercholestrolemia in lyn-deficient mice fed a high-fat-diet"Genes Cells. 6. 37-42 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Nakazawa: "Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 (NR2B) subunit of the N-methyl-D-aspartate receptor"J. Biol Chem.. 276. 693-699 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Suzuki: "A serine/threonine kinase p90rsk1 phosphorylates the antiproliferative protein Tob"Genes Cells. 6. 131-138 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N.Kobayashi: "Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis"EMBO J.. 20. 1271-1280 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y.Yoshida: "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex"J. Cancer Res.. 92. 592-596 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] F.Della-Ragione: "Genes modulated by histone acetylation as new effectors of butyrate activity"FEBS Lett.. 499. 199-204 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T.Akiyama: "Mammalian homologue of E. coli ras-like GTPase (ERA) is a possible apiptosis regulator with RNA binding activity"Genes Cells. 6. 987-1001 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I.M.Rascan: "B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM"FEBS Letters. 498. 26-31 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Umemori: "Stimulation of myelin basic Protein gene transcription by Fyn tyrosine kinase for myelination"J. Neuroscience. 19. 1393-1397 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Hayashi: "The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn"Nature. 397. 72-76 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Tsukamoto: "Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40"Proc. Natl. Acad. Sci. USA. 96. 1234-1239 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tohru Tezuka: "PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-as-partate receptor subunit NR2A"Proc. Natl. Acad. Sci. USA. 96. 435-440 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Narisawa-Saito: "Growth factor-mediated Fyn signaling regulates AMPA receptor expression in rodent neocortical neurons"Proc. Nati Acad. Sci. USA. 96. 2461-2466 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] A. Naito: "Severe osteopetrosis, devective interleukin-1 signaling and lymph node organogenesis in TRAF6-deficient mice"Genes Cells. 4. 353-362 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Horikawa: "Distinctive roles of Fyn and Lyn in IgD- and IgM-magma-Mediated signaling"Int'l Immunol. 11. 1441-1449 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Ikematsu: "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases"Oncogene. 18. 7432-7441 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Kim: "Molecular Cloning and characterization of a novel cbl-family gene, cbl-c"Gene. 239. 145-154 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] H. Umemori: "Involvement of protein tyrosine phosphatase in activation of the trimeric G protein G_<q/11>"Oncogene. 18. 7399-7402 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Muto: "Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalophathy"Neuroscience Letters. 271. 69-72 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] C. Hisatsune: "Phosphorylation-dependent interaction of the N-tnethyl-D-aspartate receptor ε2 subunit with phosphatidylinositol 3-kinase"Genes Cells. 4. 657-666 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] D.J. Caughey: "Fractionation of polyclonal antibodies to fragments of a neuroeceptor using three increasingly chaotropic solvents"J. Chromatogr. B. Biomed Sci. Appl.. 728. 49-57 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Fujimoto: "Clonigng and characterization of dfak56, a homolog of focal adhesion kinase, in drosophila melanogaster"J. Biol. Chem.. 274. 29196-29201 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] M. Martins-Green: "Tissue specific expression of Yrk kinase: implications for differentiation and inflammation"Int'l J. Biochem. and Cell Biol.. 32. 351-364 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Yamanashi: "Role of the rasGAP-associated docking protein p62dok in negative regulation of B cell receptor-mediated signaling"Genes & Dev.. 14. 11-16 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Yasuda: "Cbl suppresses B cell receptor-mediated phospholipase c-γ2 activation by regulating BLNK-PLC-γ2 binding"J. Exp. Med.. 191. 641-650 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Z. Honda: "Sequential requirements of the N-Terminal palmitoylation site and SH2 comain of Src family kinases in the initiation and progression of FcεRi signaling"Mol. Cel. Biol.. 20. 1759-1771 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] J. Inoue: "Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediated cytokine signaling"Exp. Cell Res.. 254. 14-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. M. Sharma: "Aurine Tricarboxylic Acid, a potent metal-chelating inhibitor of NFκB-DNA binding"Bioorg. Med. Chem.. 165. 473-482 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Suzuki: "Differential involvement of Src family kinases in Fcγ receptor-mediated phagocytosis"J. Immunol.. 165. 473-482 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] K. Hironaka: "The protein-tyrosine phosphatase PTPMEG interacts glutamate receptor delta 2 and epsilon subunits"J. Biol. Chem.. 275. 16167-16173 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] R. Ajima: "Cloning and characterization of the mouse tob2 gene"Gene. 253. 215-220 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. T. Sein: "A role of FAK in the concanavalin A-dependent secretion of matrix metalloproteinase-2 and -9"Oncogene. 19. 5539-5542 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Yoshida: "Negative regulation of BMP/Smad signaling by Tob in osteoblasts"Cell. 103. 1085-1097 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] S. Miki: "Reduction of artherosclerosis despite hypercholestrplemia in lyn-deficient mice fed a high-fat-diet"Genes Cells. 6. 37-42 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Nakazawa: "Characterization of Fyn-mediated tyrosine phosphorylation sites on GiuRε2 (NR2B) subunit of the N-methyl-D-aspartate receptor"J. Biol. Chem.. 276. 693-699 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Suzuki: "A serine/threonine kinase p90rsk1 phosphorylates the antiproliferative protein Tob"Genes Cells. 6. 131-138 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] N. Kobayashi: "Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis"EMBO J.. 20. 1271-80 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] I. M. Rascan: "B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM"FEBS Letters. 498. 26-31 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Y. Yoshida: "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex"Jpn. J. Cancer Res.. 92. 592-596 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] F. Della-Ragione: "Genes modulated by histone acetylation as new effectors of butyrate activity"FEBS Lett.. 499. 199-204 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] T. Akiyama: "Mammalian homologue of E. coli ras-like GTPase (ERA) is a possible apiptosis regulator with RNA binding activity"Genes Cells. 6. 987-1001 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki S: "Reduction of artherosclerosis despite hypercholestrolemia in lyndeficient mice fed a high-fat-diet"Genes Cells. 6. 37-42 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakazawa T: "Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 NR2B) subunit of the N-methyl-D-aspartate receptor"J. Biol Chem.. 276. 693-699 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Suzuki T: "A serine/threonine kinase p90rskl phosphorylates the antiproliferative protein Tob"Genes Cells. 6. 131-138 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kobayashi N: "Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis"EMBO J.. 20. 1271-1280 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yoshida Y: "Association of ANA, a member of the anti-proliferative Tob family protens, with a Cafl component of the CCR4 transcriptional regulatory complex"Jpn. J. Cancer Res.. 92. 592-596 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mlinaric-Rascan I.: "B cell receptor signaling involves physical and functional association of FAK with Lyn and IgM"FEBS Lett.. 498. 26-31 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Akiyama T: "Mammalian homologue of E. coli Ras-like GTPase (ERA)is a possible apoptosis regulator with RNA binding activity"Genes Cells. 6. 987-1001 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Della Ragione F: "Genes modulated by histone acetylation as new effectors of butyrate activity"FEBS Lett. 499. 199-204 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kohno M: "CD151 enhances cell motility and metastasis of cancer cell line in the presence of focal adhesion kinase"Int. J. Cancer. 97. 336-343 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Usui M: "Enhancing effect of Tob deficiency on bone formation is specific to BMP-induced osteogenesis"J. Bone & Mineral Res. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Kitagawa D: "Activation of extracellular signal-regulated kinase by ultraviolet is mediated through Src-dependent epidermal growth factor receptor phosphorylation. Its implication in an anti-apoptotic function"J Biol Chem. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Hashimoto R: "Lithium protection against glutamate exotoxicity in rat cerebral cortical neurons : involvement of NMDA receptor inhibition by decreasing NR2B tyrosine phosphorylation"Neurochem.. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Yokoyama K: "BANK regulates BCR-induced calcium mobilization by promoting tyrosine phosphorylation of IP3 receptor"EMBO J.. (in press).

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      2001 Annual Research Report
  • [Publications] Ysuda T: "Cb1-b positively regulates Btk-mediated activation of phospholipase Cγ2 in B cells"J. Exp. Med.. (in press).

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      2001 Annual Research Report
  • [Publications] Hironaka,K.: "The protein-tyrosine phosphatase PTPMEG interacts glutamate receptor delta 2 and epsilon subunits."J.Biol.Chem.. 275. 16167-16173 (2000)

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      2000 Annual Research Report
  • [Publications] Ajima,R.: "Cloning and characterization of the mouse tob2 gene"Gene. 253. 215-220 (2000)

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      2000 Annual Research Report
  • [Publications] Yoshida,Y.: "Negative regulation of BMP/Smad signaling by Tob in osteoblasts"Cell. 103. 1085-1097 (2000)

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      2000 Annual Research Report
  • [Publications] Miki,S.: "Reduction of artherosclerosis despite hypercholestrolemia in lyn-deficient mice fed a high-fat-diet."Genes Cells. 6. 37-42 (2000)

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      2000 Annual Research Report
  • [Publications] Nakazawa,T.: "Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR {epsilon}2(NR2B) subunit of the N-methyl-D-aspartate receptor"J.Biol.Chem. 276. 693-699 (2001)

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      2000 Annual Research Report
  • [Publications] H. Umemori: "Stimulation of Myelin Basic Protein Gene Transcription by Fyn Tyrosine Kinase for Myelination"J. Neuroscience. 19. 1393-1397 (1999)

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      1999 Annual Research Report
  • [Publications] T. Hayashi: "The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn"Nature. 397. 72-76 (1999)

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      1999 Annual Research Report
  • [Publications] T. Tezuka: "PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A"Proc. Natl. Acad. Sci. USA. 96. 435-440 (1999)

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      1999 Annual Research Report
  • [Publications] M. Saito: "Growth factor-mediated Fyn signaling regulates AMPA receptor expression in rodent neocortical neurons"Proc. Natl. Acad. Sci. USA. 96. 2461-2466 (1999)

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      1999 Annual Research Report
  • [Publications] H. Umemori: "Involvement of protein tyrosine phosphatase in activation of the trimeric O protein G"Oncogene. 18. 7399-7402 (1999)

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      1999 Annual Research Report
  • [Publications] Y. Muto: "Age-related decrease in brain-derived neurotrophic factor gene expression in the brain of the zitter rat with genetic spongiform encephalophathy"Neuroscience Letters. 271. 69-72 (1999)

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      1999 Annual Research Report
  • [Publications] C. Hisatusune: "Phosphorylation-dependent interaction of the N-methyl-D-aspartate receptor ε2 subunit with phosphatidylinositol 3-kinase"Genes to Cells. 4. 657-666 (1999)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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