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Developmental Study of Very High Resolution Micro-focus X-ray Computed Tomography for Use in Medicine to Enable Acquisition of Images of Soft Tissues.

Research Project

Project/Area Number 11359004
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section展開研究
Research Field 広領域
Research InstitutionTokyo Women's Medical University

Principal Investigator

SHIBATA Takashi (2000)  Tokyo Women's Medical University ÅE School of Medicine, Assistant, 医学部, 助手 (70222031)

永野 貞子 (1999)  東京女子医科大学, 医学部, 教授 (30075270)

Co-Investigator(Kenkyū-buntansha) AGISHI Tetuzo  Todyo Women's Medical University, School of Medicine, Emeritus Professor, 医学部, 名誉教授 (70090660)
TAKAYAMA Mikiko  Tokyo Women's Medical University, School of Medicine, Professor, 医学部, 教授 (80075481)
NAGANO Teiko  Tokyo Women's Medical University, School of Medicine, Former Professor, 医学部, 前教授 (30075270)
TAKAKURA Kintomo  Tokyo Women's Medical University, President, 医学部, 学長 (90109984)
OGAWA Tomoya  Gakushuin University, department of Physics, Professor, 理学部, 教授 (50080437)
芝田 高志  東京女子医科大学, 医学部・解剖学教室, 助手 (70222031)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥36,900,000 (Direct Cost: ¥36,900,000)
Fiscal Year 2000: ¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 1999: ¥32,200,000 (Direct Cost: ¥32,200,000)
KeywordsVery High Resolution Micro-focus X-ray Computed Tomography / micro-CT / 3D-reconstruction / Contrast resolution / Oxalosis / Arteriosclerosis / Diabetes / Conjoined twins / μ-CT / 立体再構築画像 / 動脈 / 奇形胎児 / 石灰化 / 超高分解能XCT(MFXCT) / 間葉 / 中耳 / Be窓 / ヒト胎児 / 粘膜ヒダ
Research Abstract

Very high resolution micro-focus X-ray computed tomography, so called micro-CT, for industrial use has 10^2〜10^3 times greater spatial resolution than medical CT, however, the contrast resolution of both is low and nearly the same, making it difficult to resolve soft tissues that have nearly the same X-ray absorption values. If this problem were overcoming it would enable micro-CT to be used in a broad range of medical studies, from anatomy to clinical investigations, for example. An attempt was therefore made to design and manufacture both the hard- and soft-ware of a micro-CT system for medical study by using X-ray detection system of an image intensifier having a Be-window as its area sensor, which is never employed for micro-CT, and a direct MOS image sensor as a line sensor with a 21-bit AD conversion system, a bit-depth never achieved in the past with the conventional 16-bits. The system also unique features, such as reducing X-ray exposure and a multi-axis stage to obtain option … More al sections of the specimen.
We have tried using this system to obtain continuous sections and produce 3D-reconstruction images of anatomical specimens and medical specimens. Using anatomical specimens, we successfully visualized and analyzed the cranium of asymmetric conjugated twins, especially the inner, middle, and external ear portions, whose structure it was been impossible to know for over forty years because its complexity.
All previous reports on arteries employing micro-CT were studies of casts obtained by using contrast medium, and there had never been a study of the tunica vasculosa itself. By using the amputated crus from a patient of oxalosis as a clinical specimen, however, the calcification and pathology of the tunica media of the peroneal and tibial artery caused by deposition of calcium oxalate crystals was identified for the first time. The arteries of patients with arteriosclerosis and diabetes have also been imaged. The arteries of patients with arteriosclerosis caused by diabetes have also been imaged. As an example of the medical applications of micro-CT, we demonstrate that micro-CT is useful in obtaining information on the calcified part of soft tissues, although it is difficult to obtain conventional histological sections of calcified arteries because of the loss of calcified parts because of their hardness and fragility or because of dissolution during processing.
We also describe the meaning and technical improvements in micro-CT as a tool for X-ray imaging anatomy and as practical medical equipment for the future. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] 芝田高志: "正常(健康)・異常(疾病)のバイオクリスタリゼーションならびに生体関連成分共存下の複雑系に於ける結晶成長"日本結晶成長学会雑誌(特集号). (印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takashi Shibata: "Visualization of Reissner's membrane in the internal ear of human fetuses by using 3D-reconstructed images obtained by very high resolution microfocus X-ray computed tomography"Radiology. (received).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takashi Shibata: "Normal and Abnormal Biocrystallization and Crystal Growth in Complex Systems in the presence of Biological Components."Journal of the Japanese Association for Crystal Growth. 28 (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Takashi Shibata et al.: "Visualization of Reissner's membrane in the internal ear of human fetuses by using 3D-reconstructed images obtained by very high resolution microfocus X-ray computed tomography."Radiology. (submitted). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 芝田高志: "正常(健康)・異常(疾病)のバイオクリスタリゼーションならびに生体関連成分共存下の複雑系に於ける結晶成長"日本結晶成長学会雑誌(特集号). (印刷中).

    • Related Report
      2000 Annual Research Report
  • [Publications] Takashi Shibata: "Visualization of Reissner's membrane in the internal ear of human fetuses by using 3D-reconstructed images obtained by very high resolution microfocus X-ray computed tomography"Radiology. (received).

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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