| Project/Area Number |
11450301
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
反応・分離工学
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| Research Institution | TOKYO METROPOLITAN UNIVERSITY |
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Principal Investigator |
NAGAHAMA Kunio TOKYO METROPOLITAN UNIVERSITY, APPLIED CHEMISTRY, PROFESSOR, 大学院・工学研究科, 教授 (80087311)
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| Co-Investigator(Kenkyū-buntansha) |
NORITAKA Hidetaka TOKYO METROPOLITAN UNIVERSITY, APPLIED CHEMISTRY, ASSISTANT, 大学院・工学研究科, 助手 (20237895)
KATO Satoru TOKYO METROPOLITAN UNIVERSITY, APPLIED CHEMISTRY, ASSOC. PROF, 大学院・工学研究科, 助教授 (70126316)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥4,100,000 (Direct Cost: ¥4,100,000)
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| Keywords | SUPERCRITICAL FLUID / CARBON DIOXIDE / DOCOSAHEXAENOIC ACID / EXTRACTION / CYCLODEXTRIN / CLATHRATION / AUTOXIDATION / EICOSAPENTAENOIC ACID / 魚油 / 包接化物 / 耐酸化性 / 精製 |
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| Research Abstract |
(1) TO PURIFY DOCOSAHEAENOIC ACID (DHA) IN TUNA OIL, SUPERCRITICAL FLUID EXTRACTION (SFE) WITH CARBON DIOXIDE WAS USED. FATTY ACID ETHYL ESTERS DERIVED FROM TUNA OIL WERE FRACTIONATED. THE PURIFICATION PROCESS HAS TWO STEPS : FIRST IS EXTRACTION OF UNSATURATED FATTY ACID ESTERS BY Ag(I)-COMPLEXATION AND SECOND IS PURIFICATION OF DHA BY CO2-SFE.
(2) BASED ON THE EXPERIMENTAL STUDY OF DHA EXTRACTION, PROCESS SIMULATION OF THE SFE PROCESS FOR DHA PURIFICATION HAS BEEN DONE WITH COMPUTER USING A SIMPLE MODEL.
(3) TO ENHANCE LONG-TERM STORAGE STABILITY OF PURIFIED DHA AGAINST AUTOXIDATION, WE EMPLOYED CYCLODEXTRINS (CDs) AS AN ENCAPSULAING AGENT. CD-ENCAPSULATION OF DHA IN SUPERCRITICAL C02 WAS MADE BY USE OF A N EXPERIMANTAL SETUP ; FIRST CELL IS EXTRACTION CELL. WHERE PURIFIED DHA IS PLACED AND SECOND IS CD-ENCAPSULATION CELL. BY INTRODUCING SUPERCRITICAL (SC) C2 INTO THE FIRST CELL, DHA IS DISSOLVED IN CO2 AND IT REACTS WITH CDs IN THE SECOND CELL. WE SUCCEEDED IN OBTAINING CD-ENCAPSULATED DHA USING SC-CO2. IT MAY BE THE FIRST SUCCESS IN FORMING CD-ENCASPULATED DHA UNDER SCCO2.
(4) THE STABILITY OF DHA ENCAPSULATED WITH CDs AGAINST OXIDATION WAS EVALUATED BY BOTH THERMOGRAVIMETRY AND DSC MEASUREMENTS.
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