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Regulation mechanisms of germinal cell selection in mammals and its artificial control

Research Project

Project/Area Number 11460127
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionKyoto University

Principal Investigator

MIYAMOTO Hajime  Agriculture, Kyoto Univercity, Professor, 農学研究科, 教授 (00026618)

Co-Investigator(Kenkyū-buntansha) SUGIMOTO Miki  Agriculture, kyoto univercity, assistant, 農学研究科, 助手 (20243074)
MANABE Noboru  AgricuIture, kyoto university, associate professor, 農学研究科, 助教授 (80243070)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥15,100,000 (Direct Cost: ¥15,100,000)
Fiscal Year 2001: ¥3,400,000 (Direct Cost: ¥3,400,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥8,000,000 (Direct Cost: ¥8,000,000)
KeywordsOvary / Follicle / Granulosa cell / Mammal / Apoptosis / Cell-death receptor / Monoclonal antibody / Programmed cell death / アポトーシス受容体 / デコイ受容体 / HVJ-リポソーム / 遺伝子導入 / ブタ / モノクロナール抗体
Research Abstract

In mammalian ovaries, more than 99% of the follicles undergo the degenerative change known as atresia at varying stages of follicle development. our studies of follicular atresia have revealed the morphological and biochemical characteristics of atretic follicles. our recent findings have suggested that the degeneration of atretic follicles in mammalian ovaries can be explained, at least in part, by apoptotic death of granulosa and theca interna cells. we confirmed that apoptosis occurs in granulosa cells but not cumulus cells in the atretic graafian follicles from porcine ovaries. apoptosis is the result of many stimuli that act through many signal transduction pathways culminating in the activation of endonucleases. Apoptotic stimuli and intracellular signal ransduction pathways involved in granulosa cell apoptosis remain to be determined. Therefore, understanding of the events that trigger activation of the endonucleases is essential to elucidate the pathways upstream of apoptosis. we produced monoclonal antibodies that recognize cell-surface antigens (a novel cell-death receptor) of granulosa cells and induce apoptosis of cultured granulosa cells. Such antibodies, especially PFG-1 that induces apoptosis of cultured granulosa cells, are good probes for studying the intracellular pathways of granulosa cell apoptosis in porcine atretio follicles.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (80 results)

All Other

All Publications (80 results)

  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto et al.: "TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and Devevelopment. 48. 167-173 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto et al.: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of Reproduction and Devevelopment. 48. 175-181 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Okamura, Noboru Manabe, Hajime Miyamoto et al.: "Protein tyrosine kinase expression in the porcine ovary"Molecular Human Reproduction. 7. 723-729 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Eiichi Hondo, Noboru Manabe, Hajime Miyamoto et al.: "Molecular cloning and expression of suppressor of potassium transport defect 3 (SKD3) in rat testis"Journal of Reproduction and Devevelopment. 47. 173-180 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Minako kiso, Noboru Manabe, Hajime Miyamoto et al.: "Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse (SAM)"Journal of Reproduction and Devevelopment. 47. 153-164 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuho Nakayama, Noboru Manabe, Hajime Miyamoto et al.: "Changes in localization of type I, III and IV collagens and their mRNA expression during follicular atresia in bovine and porcine ovaries"Journal of Reproduction and Devevelopment. 47. 27-31 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "A novel in vivo NMR technique to assess halocarbon induced hepatic failure in mice"Water Science and technology. 17. 32-38 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "A Novel cell death receptor and a decoy receptor on follicular granulose cells of porcine ovaries"Japanese Journal of Embryo Transfer. 23. 52-60 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Naoko Inoue, Noboru Manabe, Hajime Miyamoto et al.: "Elongation of cell cycle of early stage tetraploid murine embryos induced by cytochalasin B"Japanese Journal of Embryo Transfer. 23. 44-51 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Physiological roles of apoptosis in granulosa cells of atretic follicles in porcine ovaries"Japanese Journal of Embryo Transfer. 23. 1-10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Monoclonal antibodies recognize a novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles"Journal of Mammalian Ova Research. 18. 1-13 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maki Morita, Noboru Manabe, Hajime Miyamoto et al.: "Changes in morphology of mouse oviduct ampulla during early pregnancy"Biology of Reproduction. 64. 325 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Teratosis induced by retinoids relates to apoptotic cell death in mouse embryos. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takako Tanaka, Noboru Manabe, Hajime Miyamoto et al.: "Effects of endocrine disrupters on the expression nuclear receptor in murine embryos. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki Sugimoto, Noboru Manabe, hajime Miyamoto et al.: "Uilization of NMR microscopy in developmental toxicology : assessment of mouse embryo malformations induced by maternal administration of retinoic acid, In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Quantitative estimation of physiological properties by histochemical techniques. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "In vivo 31P-nuclear magnetic profiles of granulosa cell apoptosis in follicular atresia of porcine ovaries. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki SUGIMOTO, Noboru Manabe, Hajime Miyamoto et al.: "Histological and biochemical profiles of granulosa cell apoptosis in follicular atresia of porcine ovaries. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Cell death receptor dependent regulation of granulosa cell apoptosis in porcine ovarian follicle atresia. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuho Nakayama, Noboru Manabe, Hajime Miyamoto et al.: "Histochemical studies for comparison of regulatory mechanisms of follicular development in mammalian ovaries. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Namiko Kiso, Noboru Manabe, Hajime Miyamoto et al.: "Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse (SAM). In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maki Morita, Noboru Manabe, Hajime Miyamoto et al.: "Functions of mammalian oviducts and their relevance to morphology. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kozue Yamada-Uchio, Noboru Manabe, Hajime Miyamoto et al.: "Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Misuzu Yamaguchi, Noboru Manabe, Hajima Miyamoto et al.: "Renal anemia in ICR-derived glomerulonephritis (ICGN) mice. In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki Sugimoto, Noboru Manabe, Hajime Miyamoto et al.: "Cryopreservation of mammalian ovarian tissue, In : Miyamoto H, Manabe N (eds), Reproductive biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto,et al: "TRAILl-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and devevelopment. 4-28. 167-173 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto, et al: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of reproduction and devevelopment. 48-2. 175-181 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Hitoshi Okamura, Noboru Manabe, Hajime Miyamoto et al: "Protein tyrosine kinase expression in the porcine ovary"Molecular human reproduction. 7-6. 723-729 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Eiichi Hondo, Noboru Manabe, Hajime Miyamoto, et al: "Molecular cloning and expression of suppressor of potassium transport defect 3 (SKD3) in rat testis"Journal of reproduotion and devevelopment. 47-2. 173-180 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Minako Kiso, Noboru Manabe, Hajime Miyamoto, et al: "Abnormal acoumulation of luteal bodies in overies of the senescence accelerated mouse (SAM)"Journal of Reproduotion and Devevelopment. 47-2. 153-164 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuho Nakayama, Noboru Manabe, Hajime Miyamoto, et al: "Changes in localization of type I, III and IV collagens and their mRNA expression during follicular atresia in bovine and porcine ovaries"Journal of Reproduotion and Devevelopment. 47-1. 27-31 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, et al: "A novel in vivo NMR technique to assess halocarbon induced hepatic failure in mice"Water Science and Technology. 17-1. 32-38 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto, et al: "A novel cell death receptor and a decoy receptor on follicular granulose cells of porcine ovaries"Japanese Journal of Embryo Transfer. 23-1. 52-60 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Naoko Inoue, Noboru Manabe, Hajime Miyamoto, et al: "Elongation of cell cycle of early stage tetraploid murine embryos induced by cytochalasin B"Japanese Journal of Embryo Ttransfer. 23-1. 44-51 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto, et al: "Physiological roles of apoptosis in granulosa cells of atretic follicles in porcine ovaries"Japanese Journal of Embryo Transfer. 23-1. 1-10 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto, et al: "Monoclonal antibodies recognize a novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles"Journal of Mammalian Ova Research. 18-1. 1-13 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Malki Morita, Noboru Manabe, Hajime Mmiyamoto, et al: "Changes in morphology of mouse oviduct ampulla during early pregnancy"Bbiology of Reproduction. 64-2. 325 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe et aI: "Hokuto Publishing Co. Kyoto, Japan"Teratosis induced by retinoids relates to apoptotic cell death in mouse embryos. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Takako Tanaka, Noboru Manabe et aI: "Hokuto Publishing Co. Kyoto, Japan"Effects of endocrine disrupters on the expression of nuclear receptors in murine embryos. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki Sugimoto, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Uilization of NMR microscopy in developmental toxicology : assessment of mouse embryo malformations induced by maternal administration of retinoic acid. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Quantitative estimation of physiological properties by histochemical techniques. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"In vivo 31P- nuclear magnetic resonance technique for estimation of liver energy metabolism in mice. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki SUGIMOTO, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Histological and biochemical profiles of granulosa cell apoptosis in follicular atresia of porcine ovaries. In : Miyamoto H, Manabe N (eds). Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Cell death receptor dependent regulation of granulosa cell apoptosis in porcine ovarian follicle atresia. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mizuho Nakayama, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Histochemical studies for comparison of regulatory mechanisms of follicular development in mammalian ovaries. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Namiko Kiso, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse (SAM). In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Maki Morita, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Functions of mammalian oviducts and their relevance to morphology. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kozue Yamada-Uchio, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Abnormalities of extracellular matrix metabolisms in the kidney of ICGN mice, a strain of mice with hereditary nephrotic syndrome. In : Miyamoto H, Manabe N, (eds) Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Misuzu Yamaguchi, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Renal anemia in ICR-derived glomerulonephritis (ICGN) mice. In : Miyamoto H, Manabe N (eds), Reproductive Biotehnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Miki Sugimoto, Noboru Manabe et al: "Hokuto Publishing Co. Kyoto, Japan"Cryopreservation of mammalian ovarian tissue. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology. 424 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "In vivo noninvasive nuclear magnetic resonance (NMR) technique for assessment of teratogenicity induced by chemicals"Chemical Engineering. 47・1. 110-114 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto et al.: "TRAIL-decoy receptor-1 disappears in granulosa cells of atretic follicles in porcine ovaries"Journal of Reproduction and Devevelopment. 48・2. 167-173 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Satoko Wada, Noboru Manabe, Hajime Miyamoto et al.: "TRADD is involved in apoptosis induction in granulosa cells during atresia in pig ovaries"Journal of Reproduction and Devevelopment. 48・2. 175-181 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hitoshi Okamura, Noboru Manabe et al.: "Protein tyrosine kinase expression in the porcine ovary"Molecular Human Reproduction. 7・4. 723-729 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Eiichi Hondo, Noboru Manabe et al.: "Molecular cloning and expression of suppressor of potassium transport defect 3 (SKD3) in rat testis"Journal of Reproduction and Devevelopment. 47・2. 173-180 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Minako Kiso, Noboru Manabe, Hajime Miyamoto et al.: "Abnormal accumulation of luteal bodies in ovaries of the senescence accelerated mouse (SAM)"Journal of Reproduction and Devevelopment. 47・2. 153-164 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Mizuho Nakayama, Noboru Manabe, Hajime Miyamoto et al.: "Changes in localization of type I, III and IV collagens and their mRNA expression during follicular atresia in bovine and porcine ovaries"Journal of Reproduction and Devevelopment. 47・1. 27-36 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noboru Manabe, Hajime Miyamoto et al.: "Cell death receptor dependent regulation of granulosa cell apoptosis in porcine ovarian follicle atresia. In : Miyamoto H, Manabe N (eds), Reproductive Biotechnology : Reproductive biotechnology update and its related physiology"Hokuto Publishing Co., (Kyoto, Japan). 424 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Noboru Manabe,Miki Sugimoto,Maki Morita,Hajime Miyamoto et al.: "Anovel in vivo 31P-nuclear magnetic resonance technique for assessment of teratogenicity induced by environmental endocrine disrupters in mice."Japanese Journal of Clinical Medicine. 58・2. 108-111 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noboru Manabe,Miki Sugimoto,Maki Morita,Hajime Miyamoto et al.: "In vivo noninvasive nuclear magnetic resonance technique for assessment of teratogenicity induced by environmental pollutants."Environment Measurement and Chemical Analysis. 27・1. 60-66 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noboru Manabe,Yasuyoshi Azuma,Hajime Miyamoto et al.: "Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism and blood flow in dietary hypoferric anemic mice."British Journal of Nutrition. 83・2. 197-204 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noboru Manabe,Akira Myoumoto,Chiemi Tajima,Hajime Miyamoto et al.: "Immunochemical characteristics of a novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles."Cytotechnology. 33・2. 189-201 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mizuho Nakayama,Noboru Manabe,Hajime Miyamoto et al.: "Species specific differences in apoptotic cell localization in granulosa and theca interna cells during follicular atresia in porcine and bovine ovaries."Journal of Reproduction and Development . 46・2. 147-156 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Susumu Nishihara,Noboru Manabe,Hajime Miyamoto et al.: "Changes in cell adhesion molecules during follicular atresia in porcine ovaries."Journal of Reproduction and Development. 46・3. 325-334 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Mizuho Nakayama,Noboru Manabe,Hajime Miyamoto et al.: "Changes in localization of type I, III and IV collagens and their mRNA expression during follicular atresia in bovine and porcine ovaries."Journal of Reproduction and Devleopment. 47・1. 27-36 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kozue Uchio,Noboru Manabe,Kotaro Tamura,Makoto Miyamoto et al.: "Decreased matrix metalloproteinase activity in the kidneys of hereditary nephrotic mice (ICGN strain)."Nephron. 86・1. 145-141 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kotaro Tamura,Noboru Manabe,Kozue Uchio,Makoto Miyamoto et al.: "Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain)."The Journal of Veterinary Medical Science. 52・2. 379-390 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Noboru Manabe,Akiko Kinoshita,,Kozue Yamada-Uchio et al.: "Changes in quantitative profile of extracellular matrix components in the kidneys of rats with adriamycin-induced nephropathy."The Journal of Veterinary Medical Science. 53・1. 125-133 (2001)

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      2000 Annual Research Report
  • [Publications] Miki Sugimoto,Noboru Manabe,Hajime Miyamoto.: "Future functional-morphological studies in embryology."Journal of Reproduction and Development. 46・1. 71-77 (2000)

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      2000 Annual Research Report
  • [Publications] Noboru Manabe,Hajime Miyamoto et al.: "Immunohistochemical quantification of fast-myosin in upper hindlimb muscles of the pig."Animal Science Journal. 72・2. 154-163 (2000)

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      2000 Annual Research Report
  • [Publications] Miki Sugimoto,Noboru Manabe,Hajime Miyamoto.: "Development of infantile rat ovaries autotransplanted after cryopreservation by vitrification."Theriogenology. 53・11. 1093-1103 (2000)

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      2000 Annual Research Report
  • [Publications] Noboru Manabe,Akira Myoumoto,Chiemi Tajima,Hajime Miyamoto et al.: "A novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles."Tohoku University Press, Sendai, Japan.. 357 (2000)

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      2000 Annual Research Report
  • [Publications] Noboru MANABE et al.: "Selection of oocytes in mammalian ovaries"Tissue Culture Engineering. 25・1. 4-8 (1999)

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      1999 Annual Research Report
  • [Publications] Noboru MANABE et al.: "Endocrine-disrupting contaminants in animal products"Obstetrics and Gynaecology. 66・1. 254-265 (1999)

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      1999 Annual Research Report
  • [Publications] Yuzuru IMAI et al.: "Interactions of apoptosis and extracellular matrices in granulosa cells of atretic follicles in porcine ovaries"Journal of Mammalian Ova Research. 16・1. 59-66 (1999)

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      1999 Annual Research Report
  • [Publications] Yoshihiro KIMURA et al.: "Up-regulation of the alpha 2, 6-sialyltransferase messenger ribonucleic acid increases glycoconjugates containing alpha 2, 6-linked sialic acid residues in granulosa cells during follicular atresia of porcine ovaries"Biology of Reproduction. 60・6. 1475-1482 (1999)

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      1999 Annual Research Report
  • [Publications] Kozue UCHIO et al.: "Abnormalities of extracellular matrices and transforming growth factor beta1 localization in the kidney of the hereditary nephrotic mice (ICGN strain)"Journal of Veterinary Medical Science. 61・5. 769-776 (1999)

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      1999 Annual Research Report
  • [Publications] Noboru MANABE et al.: "Immunochemical characteristics of a novel cell death receptor and a decoy receptor on granulosa cells of porcine ovarian follicles"Cytotechnology. 14・6. 111-121 (1999)

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      1999 Annual Research Report
  • [Publications] Noboru MANABE et al.: "Regulatory mechanisms of granulosa cell apoptosis in ovarian follicle atresia: Role of granulosa cell apoptosis in porcine ovarian follicle atresia. In: Animal Cell Ttechnology. Ikura K. et al. eds."Kluwer Academic Pub. Ltd., Dordrecht, The Nederlands. 968 (1999)

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      1999 Annual Research Report
  • [Publications] Noboru MANABE et al.: "A novel in vivo NMR technique to assess halocarbon induced hepatic failure in mice. In: Hazard Assessment and Control of Environmental Contaminants. Matsui S. et al. eds."IWA Conference Com. Pub. ,Oxford, United Kingdom. 634 (1999)

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      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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