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Analyses of projection route of nitroxidergic nerve and its transmission mechanism

Research Project

Project/Area Number 11470023
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionShiga University of Medical Science

Principal Investigator

OKAMURA Tomio  Shiga University of Medical Science, Pharmacology, Professor, 医学部, 教授 (70152337)

Co-Investigator(Kenkyū-buntansha) FUJIOKA Hideyuki  Shiga University of Medical Science, Pharmacology, Research Associate, 医学部, 助手 (50228970)
AYAJIKI Kazuhide  Shiga University of Medical Science, Pharmacology, Associate Professor, 医学部, 助教授 (10167968)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2001: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2000: ¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 1999: ¥5,500,000 (Direct Cost: ¥5,500,000)
KeywordsNitric Oxide (NO) / Nitroxidergic (Nitrergic) nerve / Pterygopalatine ganglion / Vasodilator nerve / Cerebral and ophthalmic artery / Superoxide / corpus cavernosum / Hypothermia / 脳動脈 / カルシウム拮抗薬 / Caged NO / 低酸素 / 眼動脈 / 神経伝達物質 / 血管造影
Research Abstract

The aims of this study are to determine the projection route of nitroxidergic (nitrergic) nerves which innervate blood vessels and corpus cavernosum and dilate their smooth muscles, and to analyze their transmission mechanism. Summary of the study is as follows.
1. Postganglionic neurons from the pterygopalatine ganglion play crucial roles in cerebral and ophthalmic vasodilation mediated by NO from the nerve, arid preganglionic neurons, possibly from the superior salivatory nucleus through the greater superficial petrosal nerve, innervate the pterygopalatine ganglion in monkeys and dogs. Tonic discharges from the vasomotor center participate significantly in the maintenance of cerebal and ophthalmic vasodilation.
2. Nitroxidergic (nitrergic) nerves innervating porcine cerebral arteries liberate NO, but not stable products of NO, on excitation as a neurotransmitter to produce muscle relaxation, and the nerve function is protected by endogenous SOD from degradation of NO by superoxide anions.
3. Hypoxia-induced impairment of the function of nitroxidergic (nitrergic) vasodilator nerve innervating dog middle cerebral arteries is prevented by cooling, which may partially explain the effecacy of hypothermia in protecting against ischemic neuronal injury in the brain.
4.Neurogenic relaxation of canine corpus cavernosum is mediated by NO synthesized from L-arginine in nerve terminals, and this nerve is originated from ganglia located close to the corpus cavernosum but not directly from the pelvic nerve plexus.
5. N-type, but not L-type, calcium channels are responsible for increasing cytosolic free calcium, a prerequisite for the synthesis of NO, in the nitroxidergic (nitrergic) dilator nerves innervating the corpus cavernosum.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (52 results)

All Other

All Publications (52 results)

  • [Publications] Tanaka, T.: "Neurogenic vasodilation mediated by nitric oxide in porcine cerebral arteries"J.Cardiovasc.Pharmacol.. 33. 56-64 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Neurogenic vasodilation of canine isolated small labial arteries"J.Pharmacol.Exp.Ther.. 288. 1031-1036 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda M.: "Mechanism s underlying the neurogenic relaxation of isolated porcine sphincter pupillae"Exp.Eye Res.. 68. 505-512 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki, K.: "Influence of denervation on neurogenic inhibitory response of corpus cavernosum and nitric oxide synthase histochemistry"Brain Res.. 825. 14-21 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda, M.: "Neurogenic vasoconstriction as affected by cholinergic and nitroxidergic nerves in dog ciliary and ophthalmic arteries"Invest.Ophthalmol.Vis.Sci.. 40. 1753-1760 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡村 富夫: "NOとバイアグラ"血管と内皮. 9. 50-56 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated"Br.J.Pharmacol.. 127. 802-808 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡村 富夫: "NANC神経伝達物質としてのNO"神経研究の進歩. 43. 195-208 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡村 富夫: "NO作動性神経による血圧調節"血圧. 6. 484-488 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 岡村 富夫: "NO作動性神経による血管系の機能調節"実験医学. 17. 935-940 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda, N: "Cerebral vasodilatation induced by stimulation of pterygopalatine ganglion and greater petrosal nerve in anaesthetized monkeys"Neuroscience. 96. 393-398 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda, N: "Pre-and postganglionic neurons responsible for cerebral vasodilatation mediated by nitric oxide in anesthetized dogs"J.Cereb.Blood Flow & Metab.. 20. 700-708 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries"Pharmacology. 61. 251-256 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki, K.: "Evidence for nitroxidergic innervation in monkey ophthalmic arteries in vivo and in vitro"Am.J.Physiol.. 279. H2006-H2012 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Hypothermia on NO-mediated neurogenic relaxation and on hypoxic inhibition in the response of canine cerebral arteries"Hypertension Res.. 27. 47-53 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda, N: "Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries"J.Ethnopharmacol.. 76. 109-113 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki, K.: "Modifications by sumatriptan and acetylcholine of nitric oxidemediated neurogenic dilatation indog cerebral arteries"Eur.J.Pharmacol.. 420. 67-72 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki, K.: "Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries"Eur.J.Pharmacol.. 423. 179-183 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum"Jpn.J.Pharmacol.. 87. 208-213 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 安屋敷 和秀: "NO作動性神経と勃起障害"日本薬理学雑誌. 119. 21-28 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Neurogenic cerebral vasodilatation mediated by nitric oxide"Jpn.J.Pharmacol.. 88. 32-38 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tanaka T., Okamura T., Handa J. and Toda N.: "Neurogemc vasodilation mediated by nitric oxide in porcine cerebral arteries"J. Cardiovasc. Pharmacol.. 33(1). 56-64 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T., Ayajiki K., Uchiyama M. Uehara M. and Toda N: "Neurogenic vasodilatation of canine isolated small llabial arteries"J. Pharmacol. Exp. Ther.. 288. 1031-1036 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda M., Okamura T., Fujimiya M., Azuma I. andToda N.: "Mechanisms underlying the neurogenic relaxation of isolated porcine sphincter pupillae"Exp. Eye Res.. 68. 505-512 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki K., Hayashida H., Okamura T. and Toda N.: "Influence of denervation on neurogenic inhibitory response of corpus cavernosum and nitric oxide synthase histochemistry"Brain Res.. 825. 14-21 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda M., Okamura T., Ayajiki K. and Toda N.: "Neurogenic vasoconstriction as affected by cholinergic and nitroxidergic nerves in dog ciliary and ophthalmic arteries"Invest. Ophthalmol. Vis. Sci.. 40. 1753-1760 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T., Ayajiki K., Fujioka H., Toda M., Fujiyama M. and Toda N.: "Effects of endothelial impairment by saponin on the responses to vasodilators and nitrergic nerve stimulation in isolated canine corpus cavernosum"Br. J. Pharmacol.. 127. 802-808 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T., Ayajiki K. and Toda N.: "NO and viagra"Blood vessel & endotheliuim (in Japanese). 9. 50-56 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T. and Toda N.: "NO as a neurotransmitter of NANC nerve"Advances in Neurological Sciences (Shinkei Kenkyu no Shimpo) (in Japanese). 43(2). 195-208 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T.: "Regulation or blood pressure by nitroxidergic (nitrergic) nerve"Blood pressure (Ketsuatsu) (in Japanese). 6. 484-488 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T., Ayajiki K. and Toda N.: "Regulation of vascular function by NO as a neurotransmitter of vasodilator nerve"Experimental Medicine (Jikken Igaku) (in Japanese). 17. 935-940 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda N., Tanaka T., Ayajiki K. and Okamura T.: "Cerebral vasodilatation induced by stimulation of pterygopalatine ganglion and greater petrosal nerve in anaesthetized monkeys"Neuroscience. 96(2). 393-398 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda N., Ayajiki K., Tanaka T. and Okamura T.: "Pre- and postganglionic neurons responsible for cerebral vasodilatation mediated by nitric oxide in anesthetized dogs"J. Cereb. Blood Flow & Metab.. 20. 700-708 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T., Goneim H.A., Ayajiki K., Ammar E.M. and Toda N.: "Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries"Pharmacolory. 61. 251-256 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki K., Tanaka T., Okamura T. and Toda N.: "Evidence for nitroxidergic innervation in monkey ophthalmic arteries in vivo and in vitro"Am. J. Physiol.. 279. H2006-H2012 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] OkamuraT., Ayajiki K. and Toda N.: "Hypothermia on NO-mediated neurogenic relaxation and on hypoxic inhibition in the response of canine cerebral arteries"Hypertension Res.. 27. 47-53 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toda N., Ayajiki K., Fujioka H. and Okamura T.: "Ginsenoside potentiates NO-mediated neurogenic vasodilatation of monkey cerebral arteries"J. Ethnopharmacol.. 76. 109-113 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki K, Fujioka H., Noda K., Okamura T, and Toda N.: "Modifications by sumatriptan and acetylcholine of nitric oxide-mediated neurogenic dilatation in dog cerebral arteries"Eur. J. Pharmacol.. 420. 67-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki K, Fujioka H., Okamura T. and Toda N.: "Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries"Eur. J. Pharmacol.. 423. 179-183 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura T, Fujioka H. and Ayajiki K.: "Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum"Jpn. J. Pharmacol.. 87. 208-213 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ayajiki K., Toda N., and Okamura T.: "Nitroxidergic (nitrergic) nerve and erectile dysfunction"Folia Pharmacol. Jpn. (Niponyakurigaku Zasshi) (in Japanese). 119. 21-28 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] OkamuraT, Ayajiki K., Fujioka H. Shinozaki K. and Toda N.: "Neurogenic cerebral vasodilatation mediated by nitric oxide"Jpn. J. Pharmacol.. 88. 32-38 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Okamura, T.: "Hypothermia on NO-mediated neurogenic relaxation and on hypoxic inhibition in the response of canine cerebral arteries"Hypertension Res.. 27. 47-53 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ayajiki, K: "Modifications by sumatriptan and acetylcholine of nitric oxidemediated neurogenic dilatation indog cerebral arteries"Eur.J.Pharmacol.. 420. 67-72 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ayajiki, K: "Relatively selective neuronal nitric oxide synthase inhibition by 7-nitroindazole in monkey isolated cerebral arteries"Eur.J.Pharmacol.. 423. 179-183 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okamura, T.: "Effects of calcium antagonists on the nitrergic nerve function in canine corpus cavernosum"Jpn.J.Pharmacol.. 87. 208-213 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Okamura, T.: Jpn.J.Pharmacol.. 88. 32-38 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Toda,N. et al.: "Pre- and postganglionic neurons responsible for cerebral -"Journal of Cerebral Blood Flow & Metabolism. 20・4. 700-708 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ayajiki,K. et al.: "Evidence for nitroxidergic innervation in monkey ophthalmic -"American Journal of Physiology. 279・4. H2006-H2012 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Okamura,T. et al.: "Mechanisms underlying contraction and relaxation induced by -"Pharmacology. 61・4. 251-256 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Tanaka T.et al.: "Neurogenic vasodilation mediated by nitric oxide in porcine....."Journal of Cardiovascular Pharmacology. 33. 56-64 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Toda N.et al.: "Cerebral vasodilation induced by stimulation of.............."Neuroscience. 96. 393-398 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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