| Project/Area Number |
11470030
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
IGARASHI Kazuhiko DEPT.BIOCHEMISTRY, HIROSHIMA UNIVERSITY, PROFESSOR, 医学部, 教授 (00250738)
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|---|
| Project Period (FY) |
2000
|
| Project Status |
Completed (Fiscal Year 2000)
|
| Budget Amount *help |
¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2000: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1999: ¥9,100,000 (Direct Cost: ¥9,100,000)
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| Keywords | Transcription factor / nuclear structure / BTB domain / LCR / cell differentiation / cell death / クロマチン / インスレーター / 転写 / Maf |
|---|
| Research Abstract |
This study focused on the function of transcription factors Bach1 and Bach2 in regulation of chromatin structures at the molecular levels as well as their roles in hematopoietic cell differentiation. They possess the BTB/POZ domain that has been implicated in regulation of chromatin structures. To understand the biochemical basis for the BTB/POZ domain function, we searched for proteins that interact with the Bach1 BTB/POZ domain by yeast two hybrid sereening. Isolated candidates include a protein that regulates actin structure, transcritional coregulators, and structural proteins. In addition, we found that Bach2 regulates oxidative stress-induced cell death. Thus, further analysis of the interactions may pave a way to understand functional link among regulation of transcription, chromatin structures, and cell differentiation.
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