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Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter phylori-infected Mongolian Gerbils on Eradication

Research Project

Project/Area Number 11470063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

TATEMATSU Masae  Aichi Cancer Center Research Institute, Vice Director, 研究所, 副所長 (70117836)

Co-Investigator(Kenkyū-buntansha) SUGIYAMA Atsushi  Shinsyu University, First Department of Surgery, Associate Professor, 医学部・第一外科, 助教授 (90187675)
IKEHARA Yuzuru  Aichi Cancer Center Research Institute, Division of Oncological Pathology, Researcher, 腫瘍病理学部, 研究員 (10311440)
TSUKAMOTO Tetuya  Aichi Cancer Center Research Institute, Division of Oncological Pathology, Senior Researcher, 腫瘍病理学部, 主任研究員 (00236861)
Project Period (FY) 2001 – 2002
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 2001: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1999: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsMonogolian gerbils / Reversible Lesions / Halicobacter phytori / Eradication / Gastric careinogenesis / スナネズミホモログ遺伝子 / 細胞分化マーカー / スナネズミ / Helicobacter pylori / 腸上皮化生 / 胃癌
Research Abstract

Helicobacter pylori (Hp) infection is an important factor in human gastric disorders. Mongolian gerbils can be easily infected with Hp and can be ideal experimental models to clarify the role of Hp in chronic active gastritis, peptic ulcers, intestinal metaplasia, and gastric carcinoma. We have proved the enhancing effects of Hp infection in all histological types of gastric cancers of Monogolian gerbils due to exposure to chemical carcinogens.
Heterotopic Proliferative Glands (HPGs) also frequently develop with Hp infection in the glandular stomach of infected gerbils, with slightly dysplastic change of constituent cells. Distinguishing ereversible inflammatory lesions from true neoplasms upon eradication is necessary for further biological or histochemical investigations using this model. After Hp infection, glands in the stomach of Mongolian gerbils start to proliferate into the submueosa, disrupting the lamina muscularis mucosa. No papers have mentioned the histological characterist … More ics and discriminating diagnosis between these frequent submucosal proliferating glands and well-differentiated *denocareinomas in this animal species. So we verified an experimental model of long-term Hp infection and indication in gerbils. After eradication, HPGs were obviously reduced, and gastric lesions in mucosa also improved with few remnants of former injury. This fact proved the existence of reversibgle HPGs frequently induced solely with Hp infection in this animal species, related to severe gastritis, rather than malignant in character. Thus, distinguishing reversible lesions from tru neoplasms is necessary to investigate the relationship of Hp infection and gastric careinogenesis in this animal model. The precise investigation of these lesions. HPGs, including the elucidation of their possible pre-malignant characters, will provide new information concerning gastric careinogenesis. Various factors underlying inflammation, cell proliferation, apoptosis and biological mediators can be examined using the present model to help elucidate the mechanisms of gastric careinogenesis and possibly provide a lirm basis for human cancer prevention. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] Koji Nozaki: "Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori Infected Mongolian Gerbils on Eradication"Jpn J Cancer Res.. 93(4)(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuzuru Ikehara: "Polymorphisms of Two Fucosyltransferase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with the Presence of Anti-Helicobacter Pylori IgG Antibody"Cancer Epidemiol Biomarkers Prev.. 10(9). 971-977 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsuya Okino: "Sequential Histopathological Changes in vivo after Suicide Gene Therapy of Gastric Cancer Induced by N-Methyl-N'-nitro-N-nitrosoguanidine in Rats"Jpn J Cancer Res.. 92(6). 673-679 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ken-Ichi Inada: "Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach"Virchows Arch.. 439(1). 14-20 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukuto Maruta: "Role of N-Methyl-N-nitrosourea in the Induction of Intestinal Metaplasia and Gastric Adenocarcinoma in Mongolian Gerbils Ingected with Helicobacter pylori"Scand J Gastroenterol.. 36(3). 283-290 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koji Nozaki: "Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori Infected Mongolian Gerbils on Eradication"Jpn. J. Cancer Res.. 93(4)(in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuzuru Ikehara: "Polymorphisms of Two Fucosyl Transferase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with eh Presence of Anti-Helicobacter Pylori IgG Antibody"Cancer Epidemiol Biomarkers Prev.. 10(9). 971-977 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tetsuya Okino: "Sequential Histopathological Changes in vivo aftger Suicide Gene Therapy of Gastric Cancer Induced by N-Methyl-N-nitro-N- nitrosoguanidine in Rats"Jpn. J. Cancer Res.. 92(6). 673-679 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Ken-Ichi Inada: "Identification of Paneth cells in pylotic glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach"Virchows Arch.. 439(1). 14-20 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Fukuto Maruta: "Role of N-Methyl-N-nitrosourea in the Induction of Intestinal Metaplasia and Gastric Adenocarcinoma in Mongolian Gerbils Ingected with Helicobacter pylori"Scand J Gastroenterol.. 36(3). 283-290 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Koji Nozaki: "Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter pylori Infected Mongolian Gerbils on Eradication"Jpn J Cancer Res.. 93(4)(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yuzuru Ikehara: "Polymorphisms of Two Fucosyltransferase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with the Presence of Anti-Helicobacter Pylori IgG Antibody"Cancer Epidemiol Biomarkers Prev.. 10(9). 971-977 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Tetsuya Okino: "Sequential Histopathological Changes in vivo after Suicide Gene Therapy of Gastric Cancer Induced by N-Methyl-N'-nitro-N-nitrosoguanidine in Rats"Jpn J Cancer Res.. 92(6). 673-679 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Ken-Ichi Inada: "Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach"Virchows Arch.. 439(1). 14-20 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Fukuto Maruta: "Role of N-Methyl-N-nitrosourea in the Induction of Intestinal Metaplasia and Gastric Adenocarcinoma in Mongolian Gerbils Ingected with Helicobacter pylori"Scand J Gastroenterol.. 36(3). 283-290 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 牛島俊和: "Chromosomal mapping of genes controlling development.histological grade.depth of invasion. and size of rat stomach careinomas."Cancer Research. 60. 1092-1096 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 清水伸幸: "Eradication diminishes enhancing effects of Helicobacter pylori infection on Glandular stomach carcinogenesis in Mongolian gerbils."Cancer Research. 60. 1512-1514 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 稲田健一: "Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed type intestinal metaplasia of the human stomach."Virchows Archives. inpress. (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 山本昌美: "P53 knokout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach careinogenesis "Carcinogenesis. 21. 1891-1897 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中西速夫: "Rapid quantitative detection of carcinoembryonic antigen-expressing free tumor cells in the peritoneal cavity of gastric-cancer patients with real-time RT-PCR on the lightcycler."International Journal of Cancer. 89. 411-417 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 塚本徹哉: "More frequent β-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)-treated rats."Japanese Journal of Cancer Research . 91. 665-673 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu, N., Tatematsu, M. et. al.: "Helicobacterpylori intection enhances glandular stomach carcnogenesis in Mongolian gerbils treated with chemical carcinogenes"Carcinogenesis. 20(4). 669-676 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Hirayama, Y., Tatematsu, M. et. al.: "Ranematations of p53, Ki-ras, and B-catenin genes and absence of K-sain and c-erbB-2 amplification in N-methyl-N-nitro N-nitorosoguanidine-induced rat stomach cancers"Molecular carcinogenesis. 25. 42-47 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Shimizu, N., Tatematsu, M. et. al.: "New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter gylori and treated with a chemical carcinogen"J Gastorenterol. 34. 61-66 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 立松正衛、清水伸幸: "Helicobacter pylori感染と実験腺胃発癌"Frontiers in Gastroenterology. 4. 79-88 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 太田浩良、立松正衛: "H.pylori感染と胃発癌-H.pylori感染スナネズミにおける胃発癌実験を中心に-"組織培養工学. 25(8). 310-313 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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