| Project/Area Number |
11470098
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Saitama Medical School |
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Principal Investigator |
WADA Osamu Saitama medical school, Faculty of Medicine, Professor, 医学部, 教授 (60009933)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Hiroyuki Saitama medical school, Faculty of Medicine, Associate professor, 医学部, 助教授 (10200536)
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| Project Period (FY) |
1999 – 2001
|
| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥15,300,000 (Direct Cost: ¥15,300,000)
Fiscal Year 2001: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1999: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | Dioxin / Dose-response relationship / health assessment / 発癌 / ベンツピレン / 量反応関係 |
|---|
| Research Abstract |
The present study was designed to establish human health assessment based on a dose-response relationship between dioxin and humans. The level of dioxin in the lever causing liver cancer was 24 ng/g in rats. Also, the exposure level of dioxin leading to some influence was 10 ng/kg/day in rats. The level of dioxin did not reach the two values in humans. The incidence of all cancers, lung cancer and sarcoma derived from soft tissues was not defferenciated from the background incidence when examined in the group exposed to high levels of dioxin using the dose-response relationship established. Thus, the rsults of the present study demonstrate that the carcinogenicity of dioxin is not at present detected even in the group exposed to high levels of dioxin. The methodology established in the present study may be an available tool in human health assessment of dioxin.
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