• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Relationship between menopausal distress and serum estrogen, isoflavone and intake level of isoflavone

Research Project

Project/Area Number 11470106
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionGifu University

Principal Investigator

SHIMIZU Hiroyuki  Gifu University, School of Medicine, Professor, 医学部, 教授 (90073139)

Co-Investigator(Kenkyū-buntansha) HAYASHI Shinichi  Saitama Cancer Center, Research Institute, Chief Scientist, 研究所, 主任研究員 (60144862)
TAKEDA Noriyuki  Gifu University, School of Medicine, Associate Professor, 医学部, 助教授 (20163412)
NAGATA Chisato  Gifu University, School of Medicine, Associate Professor, 医学部, 助教授 (30283295)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥10,700,000 (Direct Cost: ¥10,700,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥6,800,000 (Direct Cost: ¥6,800,000)
Keywordsmenopause / soy / isoflavone / hot flush / depression / hysterectomy / エストロゲン / 骨密度 / アルカリフォスファターゼ / 閉経期 / 愁訴
Research Abstract

284 women aged 40-59 years who attended a health check-up program completed a health questionnaire including the Kupperman test of menopausal distress. Diet was also assessed by a semiquantitative food frequency questionnaire. Fermented soy product intake was significantly negatively correlated with hot flush severity ( γ = -0.16, p = 0.01 ) after controlling for age and menopausal status. Estimated isoflavone intake from total and fermented soy products was lower by 19 %.
We also analyzed the crosssectional relationships of serum concentrations of estradiol ( E2 ) and dehydroepiandrosterone sulfate ( DHEAS ) and dietary intake of soy products to psychological status measured by using Center for Epidemiologic Studies Depression Scale ( CES-D ) and other scales in 86 peri- and postmenopausal Japanese women. Serum DHEAS was inversely correlated with QES-D scale (γ = -0.22, p = -.04). Soy product intake was also inversely correlated with CES-D scale (γ = -0.22, p = -.04).
A total of 1,106 female residents aged 35-54 years who were participants of the Takayama Study, a cohort study designed by us, and who were premenopausal and completed a validated semiquantitative food frequency questionnaire. During the 6-year study period, 101 women had new moderate or severe hot flashes according to the Kupperman. After data were controlled for age, total energy intake, and menopausal status, hot flashes were inversely associated with consumption of soy products.
We also analyzed the subjects described above and found that the second tertile of isoflavone intake was associated with an decreased risk of premenopausal hysterectomy compared to the lowest tertile of intake after controlling for age and total energy ( rate ratio = 0.35, ,95 % CI = 0.13-0.97 ), although the dose-response relationship was not statistically significant.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Nagata, C., Shimizu, H., Takeda, N., et al.: "Hot flushes and other menopausal symptoms in relation to soy product intake in Japanese women"Climacteric. 2. 6-12 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata, C., Shimizu, H., Takeda, N., et al.: "Serum concentrations of estradiol and dehydroepiandrosterone sulfate and soy product intake in relation to psychologic well-being in periand postmenopausal Japanese women"Metabolism. 49. 1561-1564 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata, C., Shimizu, H., et al.: "Soy product intake and hot flashes in Japanese women : Results from a community-based prospective study"American Journal of Epidemiology. 153. 790-793 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata, C., Shimizu, H., et al.: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"European Journal of Clinical Nutrition. 55. 773-777 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata, C., Shimizu, H., Takeda, N., et al.: "Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral density in postmenopausal Japanese women"Osteoporosis Internationale. 13(in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,C., Shimizu,H., Takami,R., Hayashi,M., Takeda,N., Yasuda,K.: "Hot flushes and other menopausal symptoms in relation to soy product intake in Japanese women"Climacteric. 2. 6-12 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,C., Shimizu,H., Takami,R., Hayashi,M., Takeda,H., Yasuda,K.: "Serum concentrations of estradiol and dehydroepiandrosterone sulfate and soy product intake in relation to psychologic well-being in peri- and postmenopausal Japanese women"Metabolism. 49. 1561-1564 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,C., Takatsuka,N., Kawakami,N., Shimizu,H.: "Soy product intake and hot flashes in Japanese women - Results from a community-based prospective study"Am J Epidemiol. 153. 790-793 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,C., Takatsuka,N., Kawakami,N., Shimizu,H.: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"European Journal of Clinical Nutrition. 55. 773-777 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata,C., Shimizu,H., Takami,R., Hayashi,M., Takeda,N., Yasuda,K.: "Soy product intake and serum isoflavonoid and estradiol concentrations in gelation to bone mineral density in postmenopausai Japanese women"Osteopros Int. 13. in press (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nagata, C., Shimizu, H.他: "Soy product intake and hot flashes in Japanese women : Results from a community based prospective study"Am. J. Epidemiol.. 153. 790-793 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagata, C., Shimizu, H.他: "Soy product intake and premenopausal hysterectomy in a follow-up study of Japanese women"Eur. J. Clinical Nutrition. 55. 773-777 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagata, C., Shimizu, H., Takeda, N.他: "Soy product intake and serum isoflavonoid and estradiol concentrations in relation to bone mineral demity in postmenopausal Japanese women"Osteoporos Int. 13(印刷中). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Nagata,C., et al.: "Inverse association of soy product intake with serom androgen and estrogen concentrations in Japanese men"Nutrition and Cancer. 36. 14-18 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagata,C., et al.: "Relations of insolin resistance and serom concentrations of estradiol and sex hormone-binding globolin to potential breast cancer risk factors"Jpn.J.Cancer Res.. 91. 948-953 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagata,C., et al.: "Association of diet with the onset of menopause in Japanese Women"Am.J.Eqidemiol.. 152. 863-867 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Takatsuka,N., et al: "Hypocholesterolemic effect of soymilk supplementation with usual diet in premenopausal normolipidemic Japanese women"Preventive Medicine. 31. 308-314 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nagata,C., et al.: "Serom concentrations of estradiol and dehydroepiand rosterone sulfate and soy product in take in relation to psychologic well-being in peri-and postmeropausal Japanese women"Metabolism. 49. 1561-1564 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Shimizu, H., et al.: "Validity and reproduciibilty of a quantitative food frequency questionnaire for a cohort study in Japan"Jpn J Clin Oncol. 29. 38-44 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Nagata, C., et al.: "Association of dehydroepiandrosterone sulfate with serum HDL-cholesterol concentrations in post-menopausal Japanese women"Maturitas. 31. 21-27 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sugimoto, M., et al.: "Pharmacological treatments for GH-induced insulim resistance"Endocrine Journal. 46. S51-S53 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Tanimoto, K. et al.: "Regulation of estrogen receptor α gene mediated by promoter B responsible for its enhanced expression in human breast cancer"Nucl. Acids. Res.. 27. 903-909 (1999)

    • Related Report
      1999 Annual Research Report

URL: 

Published: 1999-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi