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Association study between the polymorphisms of neurotransmitter-related genes and suicide behavior.

Research Project

Project/Area Number 11470118
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionAkita University

Principal Investigator

YOSHIOKA Naofumi  School of Medicine, Akita University Professor, 医学部, 教授 (80108935)

Co-Investigator(Kenkyū-buntansha) ISHIZU Hideo  Okayama University Medical School, Professor, 医学部, 教授 (70033157)
KATSUMATA Yoshinao  Nagoya University School of Medicine, Professor, 医学部, 教授 (30109326)
SHIONO Hiroshi  Asahikawa Medical College, Professor, 医学部, 教授 (20112451)
NAKASONO Ichirou  Nagasaki University School of Medicine, Professor, 医学部, 教授 (30108287)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥13,400,000 (Direct Cost: ¥13,400,000)
Fiscal Year 2000: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1999: ¥9,600,000 (Direct Cost: ¥9,600,000)
KeywordsSuicide / Neurotransmitter / Allele Frequency / DNA Type / Serotonin Receptor 1A Gene / Tryptophan Hydroxylase Gene / セロトニントランスポーター
Research Abstract

We compared the genetic marker of suicide victims in Asahikawa, Akita, Nagoya, Okayama, and Nagasaki areas with a random sample of blood acquired from donation, all with informed consent. We investigated the serotonin receptor (5HT 1AR) gene and the tryptophan hydroxylase (HTH) gene. These two genes have very different but important functions in human emotional states such as happiness and despondency.
Although we examined the 5HT 1AR gene, no significant differences existed between the suicide samples and donated samples or in either 5 regions. The genotype distribution of HTH A779C of both the suicide samples and the non-suicide samples, no significant conclusions could be drawn in the males, but the UU genotype in the suicide samples was significantly higher than non suicide samples in the females. The genotype distribution of A218C among 5 areas, no significant differences for all three genotypes were discovered. However, the AA genotype in the female suicide samples was significantly higher than that of non-suicide samples. Furthermore, the haplotype distribution of HTH A779C and A218C in the suicide samples, LL-AC type in all the females and UU-AC type in the females under 60 years was significantly higher than the donated samples.
In conclusion, there is a slight association with neurotransmitter genes and suicide tendencies in this study.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 吉岡尚文: "自殺の統計的観察とその結果の反映"自殺予防と危機介入. 211. 2-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] YOSHIOKA N: "Electrophoresis in genetics and forensic analysis"Jpn.J.Electroph.. 43. 235 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SASAKI M.: "The polymorphisms of various short tandem repeats on the Y chromosome in Japanese and German Population."Int J.Legal Med.. 113. 181-188 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 勝又義直: "日本人集団におけるハーディ・ワインベルグ平衡の検定法について"日本法医学雑誌. 53. 218-216 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] ISHIZU H.: "Simultaneous analysis of eight short tandem repeat(STR)loci in forensic case works."Proceedings of the 6th Indo Pacitic Congress on Legal Medicine and Forensic Sci.. 705-708 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 津田亮一: "同一個体から得られた精液および血液のDNA profiling"Acta Crim Japon.. 66. 156-160 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 吉岡尚文: "最新電気泳動実験法"日本電気泳動学会編. 471 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] YOSHIOKA N.: "Statistical study of suicide in Japan and its relation to society."Suicide Prevention and Crisis Intervention. 21I. 2-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] YOSHIOKA N.: "Electrophoresis in genetics and forensic analysis."Jpn.J.Electroph.. 43. 235 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] SASAKI M.: "The polymorphisms of various short tandem repeats on the Y chromosome in Japanese and German population."Int.J.Legal Med.. 113. 181-188 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] KATSUMATA Y.: "Tests for Hardy-Weinberg equilibrium in Japanese population."Jpn.J.Legal med.. 53. 218-226 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] ISHIZU H.: "Simultaneous analysis of eight short tandem repeat (STR) loci in forensic case works."Proceedings of the 6^<th> Indo Pacific Congress on Legal Medicine and Forensic Science. 705-708 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] TSUDA R.: "Comparison of DNA profiling recovered from semen and blood."Acta Crim Japon. 66. 156-160 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] YOSHIOKA,N.: "Principles and applications of electrophoresis. (Editor : Japanese Electrophoresis Society)"Ishiyaku Publisher. 471 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 吉岡尚文: "自殺の統計的観察とその結果の反映"自殺予防と危機介入. 211・1. 2-8 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] YOSHIOKA N.: "Electrophoresis in genetics and forensic analysis."Jpn.J.Electroph.. 43・4. 235 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] SASAKI M.: "The polymorphisms of various short tandem repeats on the Y chromosome in Japanese and German population."Int.J.Legal Med.. 113・3. 181-188 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 勝又義直: "日本人集団におけるハーディ・ワインベルグ平衡の検定法について"日本法医学雑誌. 53・2. 218-226 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] ISHIZU H.: "Simultaneous analysis of eight short tandem repeat (STR) loci in forensic case works"Proceedings of the 6th Indo Pacific congress on Legal Medicine and Forensic Sci.. 705-708 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 津田亮一: "同一個体から得られた精液および血液のDNA profiling."Acta Crim Japon. 66・4. 156-160 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉岡尚文: "最新電気泳動実験法(日本電気泳動学会編)"医歯薬出版. 471 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 進藤祥子 他: "日本人のトリプトファンヒドロキシラーゼ遺伝子の多型"DNA多型. 7巻. 223-226 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Sasaki M.et al.: "The polymorphism of DYS388 and DYS392 on the Y chromosome in Japanese and German population"Int.J.Legal Med.. 112(2). 132-133 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 水上 創 他: "Y染色体上に存在するSTRの人類遺伝学的考察"DNA多型. 7巻. 175-177 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Matsumoto H.et al.: "Japanese population study of a Y-linked dinucleotide repeat DNA polymorphism"J.Forensic Sci.. 44. 588-591 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 池松和哉 他: "法医剖検例におけるADH2、ALDH2およびDRD4の遺伝子頻度"DNA多型. 7巻. 119-123 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 鶴屋伸一郎 他: "血液型判定用紙からのDNA profilingによる個人識別"法医学の実際と研究. 42巻. 17-20 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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