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Discovery of new sex chromosome specific markers and those application to forensic medicine and human genetics

Research Project

Project/Area Number 11470119
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Legal medicine
Research InstitutionFukui Medical University

Principal Investigator

MATSUKI Takasumi  Fukui Medical Univ., School of Medicine, Professor, 医学部, 教授 (10126617)

Co-Investigator(Kenkyū-buntansha) TAKATSUKA Hisakazu  Fukui Medical Univ., School of Medicine, Assist. Prof., 医学部, 助手 (40242490)
IIDA Reiko  Fukui Medical Univ., School of Medicine, Assist. Prof., 医学部, 助手 (40139788)
澤崎 一三  福井県警察本部, 科学捜査研究所, 主任研究員
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 2001: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2000: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1999: ¥9,200,000 (Direct Cost: ¥9,200,000)
KeywordsDXS10011 / Yfm1 / DYS441 / DYS442 / DYS443 / DYS444 / DYS445 / microsatellite / DYS442 / DYS445 / Y染色体 / X染色体 / Y chromosome / polymorphism / marker / male specific
Research Abstract

We discovered DXS10011 as a X-chromosome specific single copy marker, Yfm1 as a Y-chromosome specific multi-copy marker, DYS441, DYS442, DYS443, DYS44 and DYS445 as Y-chromosome specific single copy markers. These markers were developed for personal identification and paternity testing from forensic specimens and applied on several cases. We obtained good resolution on those cases using these markers developed on this research project.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] 松木 孝澄 ほか: "Y染色体多型マーカーDYS441,DYS442,DYS443,DYS444及びDYS445の性状とハプロタイプ解析"日本人類遺伝学会第47大会抄録集. 136 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松木 孝澄 ほか: "DXS10011型変異型3例の構造"日本DNA多型学会第11回学術集会抄録集. 84 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, et al.: "Characterization and haplotype analysis of the polymorphic Y-STRs DYS443, DYS444, and DYS445 in a Japanese population"Int J Legal Med. 116(3). 191-194 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松木 孝澄 ほか: "ヒトY染色体の新規多型マーカー5種の性状"日法医誌. 56(1). 97 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 飯田 礼子 ほか: "DNA多型 第10巻"日本DNA多型学会. 160-163 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 松木 孝澄 ほか: "DNA多型 第10巻"日本DNA多型学会. 173-175 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, Tsubota E, Matsuki T: "Identification and characterization of two novel human polymorphic STRs on Y chromosome."Int J Legal Med. 115(1). 54-56 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kato M, Kanai M, Soma O, Takusa Y, Kimura T, Numakura C, Matsuki T, Nakamura S, Hayasaka K: "Mutation of the doublecortin gene in male-patients with double cortex syndrome somatic mosaicism detected by hair root analysis"Annals Neurology. 50(4). 547-551 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, Tsubota E, Sawazaki K, Masuyama M, Matsuki T, Yasuda T, Kishi K: "Characterization and haplotype analysis of the polymorphic Y-STRs DYS443, DYS444 and DYS445 in a Japanese population"Int J Legal Med. 116(3). 191-194 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, Sawazaki K, Ikeda H, Miyamoto T, Tsubota E, Takatsuka H, Masuyama M, Matsuki T, Yasuda T, Kishi K: "A novel multiplex PCR system consisting of Y-STRs DYS441, DYS441, DYS442, DYS443, DYS444 and DYS445"J Forensic Sci. 48(5), in press, 2003, 9..

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tsubota E, Sawazaki K, Iida R, Matsuki T: "Parentage testing of deceased father case excluded by DXS10011. In : DNA Polymorphism vol.9 (Ed) Japanese Society for DNA Polymorphism Research"Toyoshoten, Tokyo, 2001, June. 135-137

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, Tsubota E, Masuyama M, Takatsuka H, Matsuki T, Yasuda T, Sawazaki K, Yamada T, Ogata Y, Kishi K: "Identification and haplotype analysis of 5 novel polymorphic Y-STRs. In : DNA Polymorphism vol.10. (Ed) Japanese Society for DNA Polymorphism Research"Toyoshoten, Tokyo, 2002, June. 160-163

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuki T, Tsubota E, Iida R, Kuroki Y, Nakahori Y: "Yfm 1 : a polymorphic multicopy marker on human Y chromosome. In : DNA Polymorphism vol.10. (Ed) Japanese Society for DNA Polymorphism Research"Toyoshoten, Tokyo, 2002, June. 173-175

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Matsuki T, Sawazaki K, Tsubota E, Iida R: "DXS10011 : a hypervariable TTTC/GAAA repeat marker on human chromosome Xq27-q28. In : Progress in Forensic Genetics 9, International Congress Series 1239. (Ed) Brinkmann B, Carracedo A, Elsevier"Amsterdam, 2003, March. 363-366

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Sawazaki K, Matsuki T, Tsubota E, Iida R, Takatsuka H, Masuryama M, Yamada T: "Structure of three mutations in DXS10011 locus. In : DNA Polymorphism vol.11. (Ed) Japanese Society for DNA Polymorphism Research"Toyoshoten, Tokyo, 2003, June, in press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Iida R, et al.: "Identiffication and characterization of two novel human polymorphic STRs on Y chromosome"Int J Legal Med. 15(1). 54-56 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kato M, et al.: "Mutation of the doublecortin gene in male patients with double cortex syndrome : somatic mosaicism detected by hair root analvsis"Annals Neurology. 50(4). 547-551 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Iida R, et al.: "Characterization and haplotype analysis of the polymorphic Y-STRs, DYS443, DYS444 and DYS445 in a Japanese population"Int J Legal Med. (in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 坪田悦子: "DNA多型 第9巻 DXS10011によって否定された擬父死亡例の親子鑑定"東洋書店. 135-137 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松木孝澄: "DNA多型 第10巻 Yfm1:ヒトY染色体上の新しいマルチコピー多型マーカー"東洋書店(印刷中). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuki T, et al.: "Progress in Forensic Genetics 10, DXS10011 : a hypervariable TTTC/GAAA repeat marker on human chromosome Xq27-q28"Elsevier(in press). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 飯田礼子: "DNA多型 第10巻 Y染色体上の新規多型性STR5種の同定とハプロタイプ解析"東洋書店(印刷中). (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 松木孝澄 ら: "ヒトY染色体多型マーカーの新規開発"日本法医学雑誌. 54(1). 83 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 澤崎一三 ら: "キャピラリー電気泳動法によるDXS10011型判定"日本法医学雑誌. 54(3). 467 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松木孝澄 ら: "Y染色体特異多型マーカーの発見"日本人類遺伝学会第54回大会抄録集. 162 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 坪田悦子 ら: "DXS10011によって否定された擬父死亡例の親子鑑定"日本DNA多型学会第9回学術集会抄録集. 78 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松木孝澄 ら: "ヒトY染色体特異多型マーカーの発見"第23回日本分子生物学会年会講演要旨集. 317 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Iida,R. et al: "Identification and characterization of two novel human polymorphic STRs on Y chromosome"Int J Legal Med. (印刷中). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 坪田悦子 ら: "DNA多型(vol.IX)"日本DNA多型学会. (印刷中) (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 松木 孝澄: "ヒトY染色体多型マーカーの新規開発"日本法医学雑誌. 54・1(印刷中). (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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