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Analysis of Emphysema and Airway Lesion in Patients with COPD

Research Project

Project/Area Number 11470139
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

MISHIMA Michiaki  Kyoto University, Medicine, Professor, 医学研究科, 教授 (60190625)

Co-Investigator(Kenkyū-buntansha) CHIN Kazuo  Kyoto University, Medicine, Associate Professor, 医学研究科, 助教授 (90197640)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥5,000,000 (Direct Cost: ¥5,000,000)
Fiscal Year 2001: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥2,600,000 (Direct Cost: ¥2,600,000)
KeywordsPulmonary Emphysema / Chronic Bronchitis / COPD / CT / Fractal analysis / 慢性閉塞性肺疾患 / 胸部CT / 気道病変 / 低吸収領域 / LAA% / WA% / 気道壁 / 気管
Research Abstract

Fractal properties are defined as a self-similarity with the different size of view, and the lung perfusion and airway branching have been reported to hava fractal propertice. We found that the size of cluster of the low attenuation area (LAA clusters) corresponding to pulmonary emphysema, and the cumulative number has a linear relationship in the log-log plot. These results suggest that the distribution of LAA clusters have a fractal distribution and that the LAA% ranged from 5% to 60%, and a half of COPD group have the normal LAA% (<30%) The fractal dimension (Df) calculated from the slope of log-log plot in COPD group with normal LAA% has smaller values than those in normal group.These results prove that COPD has a langer LAA clusters, and that the Df is a better index to find early emphysema than LAA%. The simulation using an elastic spring network model was then performed to clarify the relationship between the process of emphysema and fractal dimension. The simulation indicated t … More hat the tissue between the neighboring LAA clusters was subject to the large share stress and was easy to be destroyed, and the two LAA clusters became one cluster. This process showed the little effect on the increase of LAA% whereas the Df values predominantly decreased that the same process may be developing in the practical lung with early emphysema. The visual estimation of airway dimension such as the size of airway lumen (Ai) and airway wall thickness (T) has been performed in patients with bronchial asthma.However, the visual estimation is highly subjiective,and was not perfmed for COPD. We developed the automatic system for analyzing airway dimension,and applied it to patients with COPD The right apical bronchus (B) was analyzed because the helical CT can tangentially cut the right B.COPD had smaller Ai and Ai/BSA(body surface area),and langer T,T/BSA0.5, and WA%(ratio of wall area to whole area of airway) than normal controls. The contribution of LAA%(index of emphysema) and WA%(index of bronchitis) on the lung function indicationg airflow limitation was then estimated using multiple regression analysis. It was found that LAA% and WA% determine independently the airflow limitation, which is the definition of COPD. These results suggested that we can distinguish pulmonary enphysema and chronic bronchitis from COPD patients using CT inages. Thus, the analysis of CT images may have a great contribution on the understanding the pathogenesis and developing the new therapy of COPD. Less

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] Mishima M et al.: "Computer tomographic measurements of airway dimensions and emphysema in smokers : Correlation with lung functions"American Journal of Respiratory and Critical Care Medicine. 102. 1052-1057 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M et al.: "Distorted trachea in patients with chronic obstructive pulmonary disease"Respiration. 67. 638-644 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M et al.: "Comparison of low attenuation areas on CT between inner and outer segments of the lung in COPD patients : incidence and contribution to lung function"Thorax. 54. 384-389 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M et al.: "Optimized scanning conditions of HRCT in the follow-up of pulmonary emphysema"Journal of Computer Assisted Tomography. 23(3). 380-384 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M et al.: "Complexity of terminal airspace assessed by lung CT in normal subjects and Patients with chronic obstructive pulmonary disease"Proceedings of National Academy of Sciences. 96. 8829-8834 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakano Y, Sakai H, Mufo S, Hirai T, Itoh H, Nishimura K, Chin K, Nakamura T, Misima M: "Computer tomographic measurements of airway dimensions and emphysema in smokers : Correlation with lung functions"American journal of Respiratory and Critical Care Medicine. 102. 1052-1057 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Muro S, jNakano Y, Sakai H, Hirai T, Takubo Y, Oku Y, Chin K, Kawakami K, Nishimura K, Nakamura T, Mishima M: "Distorted trachea in patients with chronic obstructive pulmonary disease"Respiration. 67. 638-644 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Nakano Y, Sakai H, Muro S, Hirai T, Oku Y, Nishimura K, Mishima M: "Comparison of low attenuation areas on CT between inner and outer segments of the lung in COPD patients: incidence and contribution to lung function"Thorax. 54. 384-389 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M, Itoh H, Sakai H, Nakano Y, Muro S. Hirai T. Takubo.Y, Chin K, Ohi M, Nishimura K, Nakamura T: "Optimized scanning conditions of HRCT in the follow-up of pulmonary emphysema"Journal of Computer Assisted Tomography. 23(3). 380-384 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Mishima M, Hirai T, Itoh H, Nakano Y, Sakai H, Muro S, Nishimura K, Oku Y, Chin K, Ohi M, Nakamura T: "Bates JHT, Alencar AMA, Suki B. Complexity of teminal airspace assessed by lung CT in normal subjects and Patients with chronic obstructive pulmonary disease"Proceedings of National Academy of Sciences. 96. 8829-8834 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shimizu K, Chin K, Mishima M et al.: "Plasma leptin levels and cardiac sympathetic function in patients with obstructive sleep apnea-hypopnea syndrome"Thorax. (in press).

    • Related Report
      2001 Annual Research Report
  • [Publications] Nakamura T, Chin K, Mishima et al.: "Acute effect of nasal continuous positive airway pressure therapy on the systemic immunity of patients with obstructive sleep apnea syndrome"Sleep. 24. 545-553 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Chin K, Ohi M, Mishima M et al.: "Increase in bilirubin levels of patients with obstructive sleep apnea in the morning-a possible explanation of induced heme oxygenase-1"Sleep. 24. 218-223 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 三嶋理晃: "肺気量分画「機能検査からみた呼吸器診断」"メジカルレビュー社. 302 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Niimi A,Mishima M, et al.: "Relationship between wall thickness and clinical indices in asthma : assessment using computed tomography."American Journal of Respiratory and Critical Care Medicine. 102. 1518-1523 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakano Y,Mishima M, et al.: "Computer tomographic measurements of airway dimensions and emphysema in smokers : Correlation with lung functions."American Journal of Respiratory and Critical Care Medicine. 102. 1052-1057 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Muro S,Mishima M, et al.: "Distorted trachea in patients with chronic obstructive pulmonary disease."Respiration,. (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chin K,Mishima M, et al.: "Elevated levels of soluble cell adhesion molecules in patients with obstructive sleep apnea syndrome decrease following nasal continuous positive airway pressure treatment."American Journal of Medicine. 109. 562-567 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Chin K,Mishima M, et al.: "Increase in bilirubin levels of patients with obstructive sleep apnea in the morning-a possible explanation of induced heme oxygenase-1."Sleep. 24. 218-223 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Nakano Y.,Mishima M.et al.: "Comparison of low attenuation areas on CT between innner and outer segments of the lungin COPD patients: incidence and contribution to lung function"Thorax. 54. 384-389 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mishima M.,Itoh H.et al.: "Optimized scanning conditions of HRCT in the follow-up of pulmonary emphysema"Journal of Computer Assisted Tomography. 23(3). 380-384 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Mishima M.,Hirai T.et al.: "Complexity of terminal airspace assessed by lung CT in normal subjects and patients with chronic obstructive pulmonary disease"Proceedings of National Academy of Sciences. 96. 8829-8834 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Muro S.,Mishima M.et al.: "Distorted trachea in patients with chronic obstructive pulmonary disease"Respiration in press..

    • Related Report
      1999 Annual Research Report
  • [Publications] Nakano Y.,Mishima M.et al.: "CT measurements of airway dimensions and emphysema in smokers"Am. J. Crit. Care. Respir. Med. In press.

    • Related Report
      1999 Annual Research Report
  • [Publications] 三嶋理晃: "呼吸器疾患の診断に必要な CT 検査―肺野条件"呼吸器疾患-state of the arts. 医学のあゆみ別冊 (医歯薬出版). 154-157 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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