| Project/Area Number |
11470140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
MORIMOTO Shigeto Osaka University Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (20150336)
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| Co-Investigator(Kenkyū-buntansha) |
SAKURAI Shoroku Osaka University Hospital, Medical Stuff, 医学部・附属病院, 医員
KATSUYA Tomohiro Osaka University Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (30311757)
大熊 浩 大阪大学, 医学部・付属病院, 医員
清水 真澄 大阪大学, 医学部・附属病院, 医員
畑 茂樹 大阪大学, 医学部・付属病院, 医員
西部 彰 大阪大学, 医学部・付属病院, 医員
福尾 恵介 大阪大学, 医学系研究科, 講師
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 2001: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥9,300,000 (Direct Cost: ¥9,300,000)
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| Keywords | Elderly / Pneumonia / Cough-related gene / Angiotensin I-converting enzyme / Chymase / Angiotensinogen / Gene polymorphism / Morbidity |
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| Research Abstract |
Pneumonia is a major disease directly leading death in the elderly. Silent or manifest aspiration based on an age-related reduction on cough is one of major causes of pneumonia in the elderly. Although the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene (ACE) is known to associate with the cough reflex no study has been carried out on the association between pneumonia and this genetic polymorphism. The subject were 1011 elderly inpatients (221 men and 790 women, mean 【minus-plus】 SD age of 82 【minus-plus】 7 years) in a long-term care hospital. The association between ACE I/D and the incidence of pneumonia events was assessed over eight months excluding the winter season. Date were analyzed using Cox's hazards model, with adjustment for age, sex, and potential confounding factors. During the eight months of follow-up, 87 (9%) cases of pneumonia occurred (criteria of Centers for Disease Control and Prevention with chest X-ray required) in the subjects: 38 (4%) were fatal and 49 (5%) were non-fatal. After adjustment, if was shown that the ACE I/D polymorphism (DD vs. ID +II) resulted in significant risk for the: endpoints for all pneumonia [relative risk: 2.9 (95% confidence interval: 1.7-4.8), p<0.001] and fatal pneumonia [4.4 (2.1-9.0), p<0.0001]. The ACE D allele is an independent risk indicator of pneumonia events in elderly inpatients.
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