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Research for the pathogenesis and treatment of Crow-Fukase syndrome

Research Project

Project/Area Number 11470147
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKagoshima University

Principal Investigator

ARIMURA Kimiyoshi  Kagoshima University, Graduate School of Medicine and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (20159510)

Co-Investigator(Kenkyū-buntansha) HASHIGUCHI Teruto  Kagoshima University, Graduate School of Medicine and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授 (70250917)
OSAME Mitsuhiro  Kagoshima University, Graduate School of Medicine and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (10041435)
MARUYAMA Ikurou  Kagoshima University, Graduate School of Medicine and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (20082282)
UMEHARA Fujio  Kagoshima University, Graduate School of Medicine and Dental Sciences, Assistant Professor, 大学院・医歯学総合研究科, 講師 (20271140)
北島 勲  鹿児島大学, 医学部, 助教授 (50214797)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥14,200,000 (Direct Cost: ¥14,200,000)
Fiscal Year 2002: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 2001: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2000: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥6,100,000 (Direct Cost: ¥6,100,000)
KeywordsCrow-Fukase syndrome / POEMS syndrome / VEGF / platelet / Transgenic mouse / transgenic mouse / naked VEGF cDNA / neuropathy / nude mouse / matrix metalloproteinase / isoform / intraneural injection / coagulation / glioblastoma
Research Abstract

We discovered that serum VEGF levels are markedly increased in Crow-Fukase syndrome. After having confirmed this finding along with other authors, we believe that the measurement of VEGF in the serum is a key marker for the diagnosis of Crow-Fukase syndrome. We found that most of the VEGF is stored in platelets, and VEGF is released after platelet aggregation in the peripheral circulation. Furthermore, platelet counts are high in this syndrome. High concentration of VEGF and an increased number of platelets magnify the physiological effect in the peripheral vessels, which then induce a hypercoagulable state (DIC). DIC is one of the most important factors in the prognosis of Crow-Fukase syndrome. Increased VEGF in the serum may predict DIC. We succeeded in establishing a transgenic mouse line in which VEGF will be over-expressed only in platelets, as is the case in patients with this syndrome. The detailed analysis of this transgenic mouse will clarify the pathogenesis and may establish the treatment strategy in this syndrome.

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] 有村公良, 納 光弘, 橋口照人: "Vascular endothelial growth factor and Crow-Fukase syndrome"臨床神経学. 41(12). 1144-1146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koji Inoue, Wataru Matsuyama, et al.: "Increased expression of vascular endothelial growth factor in active pulmonary Aspergilloma"Intern Med. 40(12). 1195-1199 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroaki Momi, Wataru Matsuyama, et al.: "Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions"Respirat Med. 96(10). 817-822 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有村公良: "Crow-Fukase症候群とVFGF"神経研究の進歩. (In press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kimiyoshi Arimra, Yoshito Aonoda, Osamu Watanabe et al.: "Isaacs' syndrome as a potassium channelopathy of the nerve"Muscle Nerve. Supple 11. 55-58 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Wataru Matsuyama, W, Kubota R, Hashiguchi T et al.: "Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro"Immunology. 106(1). 96-101 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K, Osame M, Hashiguchi T: "Vascular endothelial growth factor and Crow-Fukase syndrome"Clin Neurology. 41. 1144-1146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Inoue K, Matsuyama K, et al.: "Increased expression of vascular endothelial growth factor in active pulmonary Aspergilloma."Intern Med. 40. 1195-1199 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Momi H, Matsuyama M, et al.: "Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions."Respirat Med. 96. 817-822 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K: "VEGF and Crow-Fukase syndrome."Advances in Neurol Sci. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Arimura K, Sonoda Y, Watanabe O, et al.: "Isaacs' syndrome as a potassium channelopathy of the nerve"Muscle Nerve Supple. 11. 55-58 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Matsuyama W, Kubota R, Hashiguchi T et al.: "Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro."Immunology. 106. 96-101 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 有村公良, 納 光弘, 橋口照人: "Vascular endothelial growth factor and Crow-Fukase syndrome"臨床神経学. 41(12). 1144-1146 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Koji Inoue, Wataru Matsuyama et al.: "Increased expression of vascular endothelial growth factor in active pulmonary Aspergilloma"Intern Med. 40(12). 1195-1199 (2001)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hiroaki Momi, Wataru Matsuyama, et al.: "Vascular endothelial growth factor and proinflammatory cytokines in pleural effusions"Respirat Med. 96(10). 817-822 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] 有村公良: "Crow-Fukase症候群とVEGF"神経研究の進歩. (In press).

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimiyoshi Arimra, Yoshito Aonoda, Osamu Watanabe et al.: "Isaacs' syndrome as a potassium channelopathy of the nerve"Muscle Nerve. Supple 11. 55-58 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Wataru Matsuyama, W, Kubota R, Hashiguchi T et al.: "Purified protein derivative of tuberculin upregulates the expression of vascular endothelial growth factor in T lymphocytes in vitro"Immunology. 106(1). 96-101 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Kimiyoshi Arimra, Yoshito Aonoda, Osamu Watanabe et al.: "Advances in Clinical Neurophysiology (Supplement to Clinical Neurophysiology Vol.54)"Ion channel disorders in neuropathy. 6(527) (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Hashiguchi T, Arimura K, Natsumuro K, et al.: "Highly concentrated vascular growth factor in platelets in Crow-Fukase syndrome"Muscle Nerve. 23. 1051-1056 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] Michizono K, Umehara F, Hashiguchi T, Arimura K, et al.: "Circulating levels of MMP-1,-2,-3,-9, and TIMP-1 are increased in POEMS syndrome"Neurology. 56. 807-810 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuyama W, Hashiguchi T, Mizoguchi A, et al.: "Serum levels of vascular endothelial growth factor dependent on the stage progression of lung cancer"Chest. 118. 948-951 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Matsuyama W, Hashiguchi T, Umehara F, et al.: "Expression of vascular endothelial growth factor in tuberculous meningitis"J Neurol Sci. 186. 75-79 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 有村公良, 橋口照人: "Crow-Fukase症候群-病院としてのVEGF.ニューロパチーの病態と治療-最近の進歩"医学のあゆみ. 195. 745-748 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Hashiguchi T,Arimura K,Matsumuro K, et al.: "Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome"Muscle Nerve. 23. 1051-056 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Niimi H,Arimra K,Jonosono M, et al.: "VEGF is causative for pulmonary hypertention in a patient with Crow-Fukase (POEMS) syndrome"Internal Medicine. 39. 1101-1104 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Michizono K,Umehara F,Hashiguchi T,Arimura K, et al.: "Circulation levels of MMP-1, MMP-2, MMP-3, MMP-9 and TIMP-1 are increased in POEMS syndrome"Neurology. 56(In press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Matsuyama W,Hashiguchi T,Mastumuro K, et al.: "Increased serum level of vascular endothelial factor in pulmonary tuberculosis"Am J Resp and Critic Care Med. 162. 1120-1122 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 有村公良: "難病の最新情報,疫学から臨床・ケアまで"南山堂. 2 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hashiguchi T,Arimura K,Matsumuro K,et.al.: "Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome."Muscle Nerve. (in press.). (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 道園 久美子、梅原 藤雄、橋口 照人、渡邊 修、有村 公良、他: "POEMS syndromeでは血中マトリックスメタロプロテイナーゼ(Matrix Metalloproteinase;MMP)は上昇している"神経免疫学. 8巻1号. 146-147 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 渡嘉敷 崇、橋口 照人、有村 公良、渡邊 修、西垂水 和隆、他: "Crow-Fukase症候群患者のDIC状態における血清vascular endothelial growth factor(VEGF)の変動"神経免疫学. 8巻1号. 142-143 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 橋口 照人、有村 公良、渡嘉敷 崇、西垂水 和隆、渡邊 修、他: "Crow-Fukase症候群患者におけるvascular endothelial growth factorは肺高血圧症の原因となりうる"神経免疫学. 8巻1号. 144-145 (2000)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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