| Project/Area Number |
11470179
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAMAKI Kunihiko Faculty of Medicine, Professor, 医学部附属病院, 教授 (30010432)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Koichiro Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (60175502)
AOSHIMA Akihiko Faculty of Medicine, Lecturer, 医学部附属病院, 講師 (50202601)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥14,600,000 (Direct Cost: ¥14,600,000)
Fiscal Year 2001: ¥2,800,000 (Direct Cost: ¥2,800,000)
Fiscal Year 2000: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1999: ¥7,600,000 (Direct Cost: ¥7,600,000)
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| Keywords | Langerhans cells / cytokine production / esiticesfeird / CD23 / Prion / IL-12 / Th_1 / TGF-β / 樹状細胞 / GM-CSF / M-CSF / TNF-α / CD40 / マウス / B7-1 / B7-2 / サイトカイン / 免疫抑制薬 / CD40L |
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| Research Abstract |
We succeeded in getting purified (over 95%) mouse Langerhans cello (LC) and analyzed their characteristics. Although we have not yet succeeded in establishment of LC-all line , we could get the following results.
(1) Using purified LC we analyzed the maturing mechanism during LC culture, (2) We also found the effect of GM-CSF, M-CSF, TNF-α, corticasteroid, cyclosporine A and FK506 on LC, (3) The effect of GM-CSF and TGF-β on IL-12 production by LC was studied. (4) CD23 expression by mouse LC and its modulation by cytokines was studied, and (4) Prion related protein expression by LC was found. The induction by TGF-βtreated LC is now under in imoestigation.
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