| Project/Area Number |
11470198
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
TSUJII Hirohiko National Institute of Radiological Sciences, 重粒子治療センター治療・診断部, 研究員 (50088853)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOE Jun-etsu National Institute of Radiological Sciences, 研究員 (80091510)
KAMADA Tadashi National Institute of Radiological Sciences, 研究員 (90150242)
YAMADA Shigeru National Institute of Radiological Sciences, 研究員 (80311380)
KATO Hirotoshi National Institute of Radiological Sciences, 研究員 (80250116)
MORITA Shinroku National Institute of Radiological Sciences, 研究員 (00182246)
TSUJI Hiroshi National Institute of Radiological Sciences, 研究員 (70207364)
遠藤 真広 放射線医学総合研究所, 重粒子治療センター治療システム開発室, 研究員 (40160402)
安藤 興一 放射線医学総合研究所, 第3研究グループ, 研究員 (00159526)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥2,700,000 (Direct Cost: ¥2,700,000)
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| Keywords | Heavy ions / Carbon ions / Charge particle therapy / Radiation complication / Morbidity / Gastrointestinal tract / Gastrointestinal toxicity / RBE |
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| Research Abstract |
Heavy ions have the beneficial property of superior physical dose localization due to exhibiting the Bragg peak in the body, as well as greater biological effectiveness than low-LET radiation (protons and photons). Accordingly, heavy ions are expected to be effective against locally advanced radio-resistant tumors and those located near critical structures. Among different types of normal tissues, however, the gastro-intestinal(GI) tract exhibits high sensitivity to heavy ions and should be assumed to be a critical organ in heavy ion therapy of the abdominal and pelvic tumors. The purpose of this study was to investigate the acute and late gastrointestinal toxicity in carbon ion therapy that had been carried out since 1994 at NIRS. Most of the patients treated had locally advanced and/or medically inoperable tumors. In the phase I/II study, the patients were initially treated with the dose that was assumed to be 10〜20% lower than that possibly tolerable for the normal tissues of intere
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st. The dose was then raised by 5〜10% increments following careful observation of normal tissue responses using the acute radiation morbidity scoring criteria (RTOG) and the late radiation morbidity scoring criteria (RTOG/EORTC).
Of the patients whose GI tract was partially or totally irradiated in the initial dose escalating trials for the patients with esophageal cancer, uterine cervix cancer, prostate cancer and abdominal tumors, 15 patients developed severe late GI complications : 2 patients in the esophagus, 13 patients in the lower bowels. Most of these complications were observed in the high dose groups, and were served for evaluation of tolerable dose(TD) of the GI tract. The TD derived from treatment of uterine cervix cancer was 57.6GyE/6 wks (or <62.4GyE) for the sigmoid colon and from treatment of prostate cancer it was 60GyE/5 wks (<66GyE) for the rectum. The TD of the esophagus was 68.4GyE/6wks or 52.8GyE/4wks. From treatment of upper abdominal tumors, the TD of the duodenum/stomach was derived to be 50〜60GyE/4〜5wks. These data were sufficiently utilized for designing new protocols for treatment of pancreatic cancer as well as pelvic recurrence after primarily resected rectal cancer. The results of the current study will be also useful for treatment of intra-abdominal tumors including the para-aortic lymph nodes and biliary tract tumors. Less
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