| Project/Area Number |
11470201
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKEI Noriyoshi Hamamatsu U Sch Med, Psychiatry, Assoc Professor, 医学部, 助教授 (80206937)
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| Co-Investigator(Kenkyū-buntansha) |
UCHIYAMA Ichiro Doshisha U, Psychology, Assoc Professor, 文学部, 助教授 (00211079)
SUZUKI Katuaki Hamamatsu U Sch Med, Psychiatry, Instructor, 医学部, 助手 (00285040)
MATSUMOTO Hideo Hamamatsu U Sch Med, Psychiatry, Assis Professor, 医学部・附属病院, 講師 (90199886)
TAKEHARA Yasuo Hamamatsu U Sch Med, Radiology, Assis Professor, 医学部・附属病院, 講師 (70188217)
ISODA Haruo Hamamatsu U Sch Med, Radiology, Assis Professor, 医学部・附属病院, 講師 (40223060)
斎藤 巨 浜松医科大学, 医学部・附属病院, 助手 (60313954)
安藤 勝久 浜松医科大学, 医学部・附属病院, 助手 (40293633)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2000: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1999: ¥5,600,000 (Direct Cost: ¥5,600,000)
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| Keywords | autistic disorder / functional magnetic resonace imaging / communication / facial recognition / non-parametric analysis / 脳形態学的測定 / SPM |
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| Research Abstract |
Autistic disorder, a condition that is characterized by the developmental impairment of language and cognitive function, is understood to be related to deficits in the ability of perceiving emotions and intentions of other persons, which is fundamental to facilitate communication between humans. During the period of financial support from the Ministry of Education, Science, Sports and Culture, we had made attempts to elucidate the brain region (s) which is linked with the pathophysiology of social dysfunctions seen in autistic patients. Paradigms used in the study were tasks of recognition of facial expression of three different emotions (i. e., happy, disgust, and fear). We applied an 'on' and 'off' alternating box car design ; in the 'on' condition, each of three different-emotion tasks was presented and, in 'off' condition, neutral faces presented. We performed scanning for 5 right-handed autistic patients and 9 right-handed healthy controls. Any differences in the brain activity during the tasks between the two groups were tested using non-parametric analysis. On the 'disgust' task, autistic subjects showed significantly lower brain activity in the insula, inferior frontal gyrus, and putamen, on the left side compared with controls. Moreover, hypofunction in the left middle frontal gyrus was revealed in autistic patients on the 'fear' task. However, no different brain activity was detected between the two groups on the 'happy' task. These results suggest that brain regions of the limbic system, particularly on the left side, are associated with the perception of facial expressions and that these areas are related to the biophysiology of the formation of autistic disorder. It is also shown that autistic patients have impairments in the recognition of some, but not all, aspects of facially expressed emotions.
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