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Prevention and treatment of chronic lung disease of the newborn infants

Research Project

Project/Area Number 11470223
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionSaitama Medical School

Principal Investigator

ARAKAWA Hiroshi (2002)  Saitama Medical School, Assitant Professor, 医学部, 講師 (90271238)

小川 雄之亮 (1999-2001)  埼玉医科大学, 医学部, 教授 (90080126)

Co-Investigator(Kenkyū-buntansha) ITAKURA Yukino  Medical School, Assitant, 医学部, 助手 (70223071)
TAKASAKI Jiro  Medical School, Assitant Professor, 医学部, 講師 (30197082)
SHIMIZU Hiroshi  Medical School, Associate Professor, 医学部, 助教授 (90260843)
中村 利彦  埼玉医科大学, 医学部, 助手 (30255137)
小俣 真  埼玉医科大学, 医学部, 助手 (70286045)
荒川 浩  埼玉医科大学, 医学部, 助手 (90271238)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥11,400,000 (Direct Cost: ¥11,400,000)
Fiscal Year 2002: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2001: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥6,600,000 (Direct Cost: ¥6,600,000)
KeywordsChronic lung disease / Pulmonary surfactant / Surfactant subtype / High frequency oscillatory ventilation / Congenital alveolar proteinosis / Surfactant protein B / Cytokine / Autoantibody / 炎症性サイトカイン / 気道吸引液 / サーファクタント蛋白質B / 高頻度振動換気法 / 活性型肺サーファクタント / 超低出世体重児 / 肺サーファクタント機能不全 / 新生児 / 新生仔ブタ / SP-B遺伝子異常 / 胎便吸引症候群 / 肺サーファクタント活性分画 / 大容量高圧陽圧換気
Research Abstract

The incidence of chronic lung disease (CLD) reaches 20% of the very low birth weight infants. In the present study, we tried to understand the pathogenesis of CLD and develop strategy for prevention and treatment of CLD.
1)Subfractions of pulmonary surfactant under high frequency oscillatory ventilation
We made a rabbit model of acute respiratory distress syndrome, then performed conventional mandatory ventilation (CMV) or high frequency oscillatory ventilation (HFOV). After 4h ventilation, bronchoalveolar lavage fluid was collected. Surfactant subtype was fractionated using ultracentrifugation and surfactant subtype conversion was evaluated in each ventilatory mode. We could demonstrate that HFOV was superior to CMV in terms of surfactant subtype conversion.
2)Congenital alveolar proteinosis and surfactant protein B deficiency in Japan
Congenital alveolar proteinosis (CAP) is classified into type VI CLD. Two cases of CAP and one case of partial surfactant protein B(SP-B) deficiency were identified in Japan between 1998 and 2002. Typical SP-B deficiency with a frame shift mutation, 121ins2, leading to a truncated nonfunctional SP-B, was not identified. We also analyzed abundance of the deletion form of SP-B mRNA, i.e., alternatively spliced SP-B mRNA in 3 cases of CAP. The contents of the "minor" SP-B mRNA in those patients were higher as compared to those in normal lungs.
3)Anti-IL-8 autoantibody in the tracheobronchial aspirates in infants with CLD
We reported previously a large amount of IL-8 in tracheobronchial aspirates during the early stage of life in type III CLD. In the present study, anti-IL-8 IgM antibody in infants with type III CLD was significantly higher as compared to type I, type II, and type V CLD. The presence of anti-IL-8 autoantibody seems to be the mechanism that limits the bioavailability of free IL-8 in the lung.

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (96 results)

All Other

All Publications (96 results)

  • [Publications] Ogawa Y., Shimizu H., Takasaki J., Nakamura T.: "Strategy for the prevention and treatment of chronic lung disease of the premature infant."Pediatric Pulmonology. 18. 212-215 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ogawa Y., Shimizu H., Itakura Y., Ohama Y., Arakawa H., Amizuka T., Obata M., Kakinuma R.: "Functional pulmonary surfactant deficiency and neonatal respiratory disorders"Pediatric Pulmonology. 18 supplement. 175-177 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 清水 浩, 小川雄之亮: "慢性肺疾患の予防と管理"産婦人科治療. 78・1. 20-25 (1999)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 小川雄之亮: "新生児における呼吸器系の成長・発達"小児看護. 22・3. 349-359 (1999)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 小川雄之亮: "超低出生体重児の慢性肺疾患の予後"周産期医学. 29・8. 977-981 (1999)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 小川雄之亮: "慢性肺疾患"小児科診療. 62・11. 1682-1689 (1999)

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      2002 Final Research Report Summary
  • [Publications] Takasaki J., Ogawa Y.: "Interleukin 8 in the tracheobronchial aspirate of infants acts as a neutrophil chemotactic factor in the development of chronic lung disease"Pediatrics International. 41・1. 78-81 (1999)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ohama Y., Ogawa Y.: "Treatment of meconium aspiration syndrome with surfactant lavage in an experimental rabbit model"Pediatric Pulmonology. 28・1. 18-23 (1999)

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      2002 Final Research Report Summary
  • [Publications] 網塚貴介, 清水 浩, 荒川 浩, 新飯田裕一, 小川雄之亮: "出血性肺浮腫に対する肺サーファクタント補充療法"日本界面医学会雑誌. 30・1-2. 17-19 (1999)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] Koyama N., Ogawa Y.: "Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema"European Journal of Pediatrics. 158・10. 858-862 (1999)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 川崎浩司, 清水 浩, 柿沼亮太, 小俣 真, 小川雄之亮: "胎便添加によるサーファクタントTA活性阻害機構"日本界面医学会雑誌. 30・1-2. 150-152 (1999)

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      2002 Final Research Report Summary
  • [Publications] 高崎二郎, 小川雄之亮: "慢性肺疾患の発症過程における気道吸引液中抗IL-8自己抗体の測定"日本新生児学会雑誌. 36・1. 1-5 (1999)

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      2002 Final Research Report Summary
  • [Publications] Ogawa Y., Shimizu H.: "Current strategy for management of meconium aspiration syndrome"Acta Paediatrica Taiwan. 41・5. 241-245 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 清水 浩, 荒川 浩, 小俣 真, 佐野仁美, 小川雄之亮: "肺胞蛋白症"日本胸部臨床. 59. 256-262 (2000)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 柿沼亮太, 清水 浩, 小川雄之亮: "胎便中のジイソプロピルフルオロリン酸結合蛋白質"日本界面医学会雑誌. 31・1-2. 99-100 (2000)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 李 光薫, 小川雄之亮: "Rosen-Castleman-Liebow症候群(pulmonary alveolar proteinosis)"小児科診療. 64・増刊. 177 (2001)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ogawa Y., Itabashi K.: "Home therapy : Oxygen and nutrition"Pediatric Pulmonology. 23. 132-134 (2001)

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    • Related Report
      2002 Final Research Report Summary
  • [Publications] 清水 浩, 荒川 浩, 小俣 真, 菅原志保子, 小川雄之亮: "肺サーファクタント蛋白質Bの遺伝子変異と呼吸器疾患"THE LUNG perspectives. 9・4. 471-476 (2001)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 小川雄之亮: "成熟児の呼吸生理"Neonatal Care. 177. 10-19 (2001)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 小川雄之亮: "慢性肺疾患"周産期医学. 31・増刊. 446-448 (2001)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takasaki J., Ogawa Y.: "Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease"Pediatrics International. 43. 48-52 (2001)

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      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Kaneko K., Shimizu H., Arakawa H., Ogawa Y.: "Pulmonary surfactant protein A in sera for assessing neonatal lung maturation"Early Human Development. 62. 11-21 (2001)

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      2002 Final Research Report Summary
  • [Publications] Nakamura T., Ogawa Y.: "Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury induced by the intratracheal instillation of endotoxin in piglets"Biology of the Neonate. 80. 163-168 (2001)

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      2002 Final Research Report Summary
  • [Publications] Nakamura T., Ezaki S., Takasaki J., Itabashi K., Ogawa Y.: "Leukemoid reaction and chronic lung disease in infants with very low birth weight"The Journal of Maternal-Fetal and Neonatal Medicine. 11. 396-399 (2002)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 金子広司, 荒川 浩, 小俣 真, 佐野仁美, 小川雄之亮: "血清中肺サーファクタント蛋白質Aによる新生児肺成熟度評価"臨床呼吸生理. 33・1. 15-17 (2001)

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      2002 Final Research Report Summary
  • [Publications] Sano H., Kuroki Y., Shimizu H., Ogawa Y.: "The surfactant components modulate the immune responses to lipopolysaccharides"日本界面医学会雑誌. 32・1-2. 86 (2001)

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      「研究成果報告書概要(和文)」より
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      2002 Final Research Report Summary
  • [Publications] 中村利彦, 田中理砂, 新田啓三, 小川雄之亮: "超低出生体重児慢性肺疾患III型に原発性小腸捻転症を合併した1例"日本小児科学会雑誌. 105・4. 475-478 (2001)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 小川雄之亮: "成人期を迎える新生児慢性肺疾患"呼吸. 21・1. 3-12 (2002)

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      2002 Final Research Report Summary
  • [Publications] 高崎二郎, 小川雄之亮: "乳児慢性呼吸器疾患"小児科臨床. 55・4. 713-716 (2002)

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      2002 Final Research Report Summary
  • [Publications] Kakinuma R., Shimizu H., Ogawa Y.: "Effect of meconium on the rate of in vitro subtype conversion of swine pulmonary surfactant"European Journal Pediatrics. 161. 31-36 (2002)

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      2002 Final Research Report Summary
  • [Publications] 武内可尚, 長秀男, 山下行雄, 御宿百合子, 中尾歩, 麻生泰二, 仁志田博司, 高橋尚人, 佐久間泉, 川上義, 余田仁志, 麦島秀雄, 湊通嘉, 田口順教, 嶋田優美, 武隈孝治, 武井章, 高見剛, 小川雄之亮, 清水浩, 高田栄子, 板橋家頭夫, 板倉敬乃, 中村利彦, 楠田聡, 金太章, 宍田紀夫, 宮城伸浩: "早産児および慢性肺疾患児におけるpalivizumabの安全性および薬物動態の検討"日本化学療法学会雑誌. 50・4. 215-222 (2002)

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  • [Publications] 清水 浩, 荒川 浩, 小俣 真, 小川雄之亮: "先天性肺胞蛋白症におけるalternatively-spliced surfactant protein B mRNAの発"日本界面医学会雑誌. 33・1-2. 65-66 (2002)

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      2002 Final Research Report Summary
  • [Publications] 荒川 浩, 清水 浩, 小川雄之亮: "高頻度振動換気が幼若家兎肺サーファクタント代謝に及ぼす影響"臨床呼吸生理. 34・2. 111-114 (2002)

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      2002 Final Research Report Summary
  • [Publications] Nakamura T., Takasaki J., Ogawa Y.: "Inflammatory changes in the lungs of premature infants with symptomatic patent ductus arteriosus"Pediatrics International. 44. 363-367 (2002)

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      2002 Final Research Report Summary
  • [Publications] 中村利彦, 板倉敬乃, 板橋家頭夫, 小川雄之亮: "慢性肺疾患III、III′型の生直後における予測"日本未熟児新生児学会雑誌. 15・1. 51-56 (2003)

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      2002 Final Research Report Summary
  • [Publications] 清水 浩, 荒川 浩, 李 光薫, 小俣 真, 小川雄之亮: "わが国における先天性肺胞蛋白症、先天性SP-B欠損症の患者発生:新生児希有疾患(病態)サーベイランス事業報告"日本未熟児新生児学会雑誌. 15・1. 107-111 (2003)

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      2002 Final Research Report Summary
  • [Publications] Amizuka T., Shimizu H., Niida Y., Ogawa Y.: "Surfactant therapy in neonates with respiratory failure due to hemorrhagic pulmonary edema"European Journal of Pediatrics. 印刷中.

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      2002 Final Research Report Summary
  • [Publications] 小川雄之亮: "Systematic Reviewにもとづいた新生児慢性肺疾患の診療指針 新生児慢性肺疾患の診療指針"メディカ出版. (1999)

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      2002 Final Research Report Summary
  • [Publications] 小川雄之亮, 多田裕, 中村肇, 仁志田博司: "新生児疾患 -呼吸器- 新生児学 第2版"メディカ出版. 482-519 (2000)

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  • [Publications] 小川雄之亮: "肺サーファクタントと呼吸器疾患-SP-Aを中心に- PROGRESS IN MEDICINE20"ライフサイエンス・メディカ. 675-682 (2000)

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  • [Publications] 小川雄之亮: "呼吸窮迫症候群(RDS) 今日の小児治療指針12"医学書院. 97-98 (2000)

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      2002 Final Research Report Summary
  • [Publications] Yunosuke_Ogawa, Hiroshi Shimizu, Jiro Takasaki, Toshihiko Nakamura: "Strategy for the prevention and treatment of chronic lung disease of the premature infant"Pediatr Pulmonol. Suppl18. 212-215 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yunosuke ogawa, Hiroshi Shimizu, Yukino Itakura, Yoichi Ohama, Hiroshi Arakawa, Takasuke Amizuka, Makoto Obata, Ryota Kakinuma: "Functional pulmonary surfactant deficiency and neonatal respiratory disorders."Pediatr Pulmonl. Suppl18. 175-177 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Yunosuke_Ogawa: "Prophylaxis and management of chronic lung disease. (in Japanese)"Obstet and Gynecol Therapy. 78. 20-25 (1999)

    • Description
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      2002 Final Research Report Summary
  • [Publications] Yinosuke Ogawa: "Growth and development of respiratory system in newborn infants (in Japanese)."Jpn J Child Nursing. 22. 349-359 (1999)

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      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Yunosuke_Ogawa: "Prognosis of chronic lung disease in extremely premature infants (in Japanese)."Perinatal Medicine (Tokyo). 29. 977-981 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Yunosuke Ogawa: "Chronic lung disease. (in Japanese)"J Pediatr Practice. 62. 1682-1689 (1999)

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      2002 Final Research Report Summary
  • [Publications] Jiro Takasaki, Yunosuke Ogawa: "Interleukin 8 in the tracheobronchial aspirate of infants acts as a neutrophil chemotactic factor in the development of chronic lung disease"Pediatr International. 41. 78-81 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoichi Ohama, Yunosuke_Ogawa: "Treatment of meconium aspiration syndrome with surfactant lavage in an experimental rabbit model."Pediatric Pulmonology. 28. 18-23 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takasuke Amizuka, Hiroshi Shimizu, Hiroshi Arakawa, Yuichi Niida, Yunosuke ogawa: "(in Japanese)"J Jpn Med Soc Biol Interface. 30. 17-19 (1999)

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      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Norihisa Koyama, Yunosuke Ogawa: "Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema."European Journal of Pediatrics. 158. 858-862 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Kawasaki, Hiroshi Shimizu, Ryota Kakinuma, Makoto Obata, Yunosuke Ogawa: "Inhibition of Surfactant TA by meconium (in Japanese)."J Jpn Med Soc Biol Interface. 30. 150-152 (1999)

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    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jiro Takasaki, Yunosuke_Ogawa: "Anti-IL-8 autoantibodies in the tracheobronchial aspirate of infants in the development of chronic lung disease. (in Japanese)"Acta Neonatol Japonica. 36. 1-5 (1999)

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      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Yunosuke Ogawa, Hiroshi Shimizu: "Current strategy for management of meconium aspiration syndrome."Acta Paediatr Tw. 41. 241-245 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Hiroshi Arakawa, Makoto Obata, Hitomi Sano, Yunosuke Ogawa: "Pulmonary alveolar proteinosis (in Japanese)."Jpn J Chest Disease. Suppl59. 256-262 (2000)

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      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Ryota Kakinuma, Hiroshi Shimizu, Yunosuke Ogawa: "Diisopropylfluorophosphate binding protein in meconium as a component which exhibits surfactant conversion activity, or activates "surfactant convertase" (in Japanese)"J Jpn Med Soc Biol Interface. 31. 99-100 (2000)

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      「研究成果報告書概要(欧文)」より
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      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Gwang-Hoon Lee, Yunosuke Ogawa: "Rosen-Castleman-Liebow syndrome (pulmonary alveolar proteinosis) (in Japanese)"J Pediatr Practice. 64Suppl. 177 (2001)

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      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yunosuke_Ogawa, Kazuo Itabashi: "Home therapy : Oxygen and nutrition"Pediatric Pulmonology. 23. 132-134 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Hiroshi Arakawa, Makoto Obata, Shihoko Yunosuke Ogawa: "Gene mutation of surfactant protein B and respiratory disease (in Japanese)."The Lung perspective. 9. 471-476 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yunosuke Ogawa: "Respiratory physiology in mature infants (in Japanese)"Neonatal Care. 177. 10-19 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Yunosuke Ogawa: "Chronic lung disease (in Japanese)."Perinatal Medicine (Tokyo). 31. 446-448 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jiro Takasaki, Yunosuke Ogawa: "Anti-interleukin-8 autoantibody in the tracheobronchial aspirate of infants with chronic lung disease"Pediatr International. 43. 48-52 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Koji Kaneko, Hiroshi Shimizu, Hiroshi Arakawa, Yunosuke Ogawa: "Pulmonary surfactant protein A in sera for assessing neonatal lung maturation."Early Human Development. 62. 11-21 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiko Nakamura, Yunosuke Ogawa: "Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury induced by the intratracheal instillation of endotoxin in piglets."Biol Neonate. 80. 163-168 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiko Nakamura, Syoichi Ezaki, Jiro Takasaki, Kazuo Itabashi, Yunosuke Ogawa: "Leukemoid reaction and chronic lung disease in infants with very low birth weight."J Maternal-Fetal Neonat Med. 11. 396-399 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Koji Kaneko, Hiroshi Arakawa, Makoto Obata, Hitomi Sano, Yunosuke Ogawa: "Pulmonary surfactant protein A in sera for assessing neonatal lung maturation (in Japanese)."J Clin Respir Physiol. 33. 15-17 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hitomi Sano, Yoshio Kuroki, Hiroshi Shimizu, Yunosuke Ogawa: "The surfactant components modulate the immune response to lipopolysaccharides (in Japanese)."J Jpn Med Soc Biol Interface. 32. 86 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiko Nakamura, Risa Tanaka, Keizo Nitta, Yunosuke Ogawa: "An extremely low birth weight infant with chronic lung disease type III complicated with primary volvulus : An observation on possible remote lung injury (in Japanese)."J Jpn Pediatr Soc. 105. 475-478 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Yunosuke Ogawa: "Chronic lung disease in the newborn (in Japanese)."Respir Res. 21. 3-12 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Jiro Takasaki, Yunosuke Ogawa: Jpn J Pediatr. 55. 713-716 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Ryota Kakinuma, Hiroshi Shimizu, Yunosuke Ogawa: "Effect of meconium on the rate of in vitro subtype conversion of swine pulmonary surfactant"Eur J Pediatr. 161. 31-36 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Yoshinao Takeuchi, Hideo Cho, Yukio Yamashita, Yuriko Mishiku, Ayumi Nakao, Taiji Aso, Hiroshi Nishida, Naoto Takahashi, Izumi Sakuma, Tadashi Kawakami, Hitoshi Yoda, Hideo Mugishima, Michiyoshi Minato, Masanori Taguchi, Masami Shimada, Koji Takekuma, Akito Takei, Tsuyoshi Takami, Yunosuke_Ogawa, Hiroshi Shimizu, Eiko Takada, Kazuo Itabashi, Yukino Itakura, Toshihiko Nakamura, Satoshi Kusuda, Tashou Kim, Norio Shishida, Nobuhiro Miyagi: "Safety and pharmacokinetics of palivizumab, administered in infants with a history of prematurity or chronic lung disease (in Japanese)."Jpn J Chemotherapy. 50. 215-222 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Hiroshi Arakawa, Makoto Obata, Yunosuke_Ogawa: "Alternatively spliced surfactant protein B mRNA in congenital alveolar proteinosis (in Japanese)."J Jpn Med Soc Biol Interface. 33. 65-66 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Arakawa, Hiroshi Shimizu, Yunosuke Ogawa: "Subfractions of pulmonary surfactant under high frequency oscillatory ventilation (in Japanese)."J Clin Respir Physiol. 34. 111-114 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiko Nakamura, Jiro Takasaki J, Yunosuke Ogawa: "Inflammatory changes in the lungs of premature infants with symptomatic patent ductus arterious."Pediatr International. 44. 363-367 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Toshihiko Nakamura, Yukino Itakura, Kazuo Itabashi, Yunosuke Ogawa: "Very early post-natal prediction of type III, IIIchronic lung disease by the combination of tracheal aspirate and peripheral blood cytology (in Japanese)."J Jpn Soc Premature Newborn Med. 15. 51-56 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroshi Shimizu, Hiroshi Arakawa, Gwang-Hoon Lee, Makoto Obata, Yunosuke Ogawa: "Report of congenital alveolar proteinosis and surfactant protein B deficiency in Japan : Japan Neonatal Surveillance Project (in Japanese)."J Jpn Soc Premature Newborn Med. 15. 107-111 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Takasuke Amizuka, Hiroshi Shimizu, Yuichi Niida, Yunosuke Ogawa: "Surfactant therapy in neonates with respiratory failure due to hemorrhagic pulmonary edema"Eur J Pediatr. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 高崎二郎, 小川雄之亮: "慢性肺疾患の発症過程における気道吸引液中抗IL-8自己抗体の測定"日本新生児学会雑誌. 36・1. 1-5 (2000)

    • Related Report
      2002 Annual Research Report
  • [Publications] 清水 浩, 荒川 浩, 李 光薫, 他: "わが国における先天性肺胞蛋白症、先天性SP-B欠損症の患者発生:新生児希有疾患(病態)サーベイランス事業報告"日本未熟児新生児学会雑誌. 15・1. 107-111 (2003)

    • Related Report
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  • [Publications] 荒川 浩, 清水 浩, 小川雄之亮: "高頻度振動換気が幼若家兎肺サーファクタント代謝に及ぼす影響"臨床呼吸生理. 34・2. 111-114 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Shimizu H, Lee G, Arakawa H, et al.: "Alternatively spliced surfactant protein B mRNA in congenital alveolar proteinosis in Japan"Am J Respir Crit Care Med. 165. A78 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] Obata M, Shimizu H, Ohama Y, et al.: "Altered pulmonary surfactant subtype in a newborn piglet model of meconium aspiration syndrome"Am J Respir Crit Care Med. 165. A79 (2002)

    • Related Report
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  • [Publications] 小川雄之亮: "未熟児・新生児の呼吸障害"日本小児呼吸器疾患学会雑誌. 12,1. 60-66 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yunosuke Ogawa, Kazuo Itabashi: "Home Therapy : Oxygen and Nutrition"PEDIATRIC PULMONOLOGY. 23. 132-134 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小川雄之亮: "成熟児の呼吸生理"Neonatal Care. 177. 10-19 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小川雄之亮: "Chronic Lung Disease in Very Low Birth Weight Infants. Role of Cytokines and Strategies for the Management"Proceedings of the 5 World Congress of Perinatal Medicine. 727-731 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 小川雄之亮: "The Prognosis of Extremely Low Birth Weight Infants"Proceedings of the 5 Eorld Congress of Perinatal Medicine. 746-750 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 柿沼亮太,清水浩,小川雄之亮: "胎便中のジイソプロピルフルオロリン酸結合蛋白質"日本界面医学会. 31,1・2. 99-100 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小川雄之亮: "呼吸管理の変遷"周産期医学. 30,12. 1673-1679 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 清水浩,荒川浩,小俣真,佐野仁美,小川雄之亮: "肺胞蛋白症"日本胸部臨床. 59. 256-262 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小川雄之亮: "新生児疾患-呼吸器-"新生児学第2版. 482-519 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Y.Ogawa,H.Shimizu: "Current Strategy for Management of Meconium Aspiration Syndrome"Acta paediatr Tw. 241-245 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ohama Y, Ogawa Y.: "Treatment of meconium aspiration syndrome. with surfactant lavage in an experimental rabbit model"Pediatric Pulmonology. 28(1). 18-23 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogawa Y, Shimizu H, Takasaki J, Nakmura T.: "Strategy for the prevention and treatment of chronic lung disease of the premature infant"Pediatric Pulmonology. Suppl 18. 212-215 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Ogawa Y, Shimizu H, Itakura Y, et al.: "Functional pulmonary surfactant deficiency and neonatal respiratory disorders"Pediatric Pulmonology. Suppl 18. 175-177 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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