| Project/Area Number |
11470290
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIMINE Toshiki Osaka University Graduated School of Medicine, Professor, 医学系研究科, 教授 (00201046)
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| Co-Investigator(Kenkyū-buntansha) |
HIRABUKI Norio Osaka University Graduated School of Medicine, Lecture, Instructor, 医学系研究科, 講師 (00189862)
MAUNO Motohiko Osaka University Graduated School of Medicine, Lecture, Instructor, 医学系研究科, 講師 (10263287)
KATO Amami Osaka University Graduated School of Medicine, Lecture, Instructor, 医学系研究科, 講師 (00233776)
NAKAMURA Hironobu Osaka University Graduated School of Medicine, Professor, 医学系研究科, 教授 (00116071)
西村 恒彦 大阪大学, 医学系研究科, 教授 (70237733)
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| Project Period (FY) |
1999 – 2000
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| Project Status |
Completed (Fiscal Year 2000)
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| Budget Amount *help |
¥13,300,000 (Direct Cost: ¥13,300,000)
Fiscal Year 2000: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1999: ¥11,600,000 (Direct Cost: ¥11,600,000)
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| Keywords | magnetoencephalography / spatial filtering / synthetic aperture magnetometry. / brain rhythm / synthetic aperture method / functional mapping / brain functionmotor function / sensory function, language, epilepsy / 脳磁図 / SAM仮想センサー法 |
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| Research Abstract |
The equivalent current dipole (ECD) method conventionally used for analysis for magnetoencephalography represent the activated brain area as one or small number of dipoles. It is not enough for comprehensive understanding of the brain activity, since the functional process of the brain is derived from the activation of neurons in a certain volume of cortex and ECD only displays the center of gravity of activated brain as a representative single point. We applied recently developed synthetic aperture magnetometry (SAM) with a spatially-selective beamformer, which filters out the background brain noise from other regions to obtain the meaningful signals from the arbitrary target regions. The neuromagnetic signals are transformed into units of dipole moment on a per voxel basis ; this enables one to measure the current density of the small portion of the brain with an enhanced sensitivity (SAM virtual sensor method). With further application of statistical imaging technique, statistical d
… More
ifference in the power of selected frequency band can be evaluated between the active and control states. Those areas with statistical difference can be displayed on the individual MRI in a tomographic manner (SAM statistical method). In this study, following neuro-functional processes were analyzed. Owing to the superior spatial resolution of the MEG and to the novel filtering technique of SAM, the tomography of neuromagnetic event related synchronization (ERS) or desynchronization (ERD) evoked by neurological task was demonstrated for the whole brain.
1. Motor-related brain activity
The influence of the hemispheric dominance as well as hand dominance wasdisclosed.
2. Sensory-related brain activity
Simultaneous and multifocal brain activations with very high frequency oscillation were disclosed.
3. Language-related brain activity
Both sensory and motor language area were demonstrated with reading without phonation task.
4. Epilepsy
The SAM virtual sensor method demonstrated the origin and the propagation process of epileptic discharges as if the intracranial electrodes were implanted. The elimination of invasive monitoring was implied. Less
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