| Project/Area Number |
11470296
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
SAKAKI Toshisuke Nara Medical University, Professor, 医学部, 教授 (20118029)
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| Co-Investigator(Kenkyū-buntansha) |
NAKASE Hiroyuki Nara Medical University, Assistant Professor, 医学部, 講師 (10217739)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥6,800,000 (Direct Cost: ¥6,800,000)
Fiscal Year 2001: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2000: ¥5,900,000 (Direct Cost: ¥5,900,000)
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| Keywords | Venous hypertension / Cerebral blood flow / Venous ischemia / 脳組織酸素濃度 / Small Volume Resuscitation |
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| Research Abstract |
We evaluated changes of regional cerebral venous flow (rCBF) and cerebral blood volume (rCBV) in chronic venous hypertension model in rat. Venous hypertension was induced by an end-to-end anastomosis between the right carotid artery and the right external jugular vein.Local CBF (1CBF) and 1CBV at 25 locations were assessed by a modern laser Doppler "scanning" technique at 4 times ; before and after the anastomosis, 2 weeks after, and after the clip of the fistula. The animals were classified two groups ; sham-operated group (n = 6) (the carotid artery occlusion only) and bypass group (n = 10). In the sham group and the left hemisphere of the bypass group, both of rCBF and rCBV didn't change. However, in the right hemisphere rCBV significantly increased 2 weeks after the bypass but recovered after clipping of the fistula (p < 0.05), and rCBF significantly decreased 2 weeks after the bypass but recovered after clipping of the fistula (P < 0.05).
In conclusion, the rat model of carotid-jugular arteriovenous fistula is clinically relevant and useful for studing the pathophysiology of chronic venous hypertension. Venous ischemia is a reversible condition which can be improved by appropriate early-stage treatment.
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