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A NOVEL EXPERIMENTAL MODEL FOR CERVICAL MYELOPATHY.RESEARCH FOR DELAYED MOTOR DISTURBANCE CAUSED BY CHRONIC SPINAL COMPRESSION.

Research Project

Project/Area Number 11470297
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionDOKKYO UNIVERSITY SCHOOL OF MEDICINE

Principal Investigator

KAWANOTO Toshiki  DOKKYO UNIVERSITY, SCHOOL OF MEDICINE, Instructor, 医学部, 助手 (50301461)

Co-Investigator(Kenkyū-buntansha) OKUHATA Soshi  DOKKYO UNIVERSITY, SCHOOL OF MEDICINE, Lecturer, 医学部, 講師 (20194508)
KIM Phyo  DOKKYO UNIVERSITY, SCHOOL OF MEDICINE, Professor, 医学部, 教授 (90231290)
渡辺 邦彦  獨協医科大学, 医学部, 講師 (00230954)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥15,500,000 (Direct Cost: ¥15,500,000)
Fiscal Year 2000: ¥5,200,000 (Direct Cost: ¥5,200,000)
Fiscal Year 1999: ¥10,300,000 (Direct Cost: ¥10,300,000)
Keywordschronic cord compression / spinal cord / neuronal loss / rat / apoptosis / microvascular anatomy / compression myelopathy
Research Abstract

A novel experimental model for cervical myelopathy was developed in the rat. A thin expanding polymer was inserted under the cervical laminae without cord injury. After the insertion (cord compression), voluntary exercise activity and locomotion capability were monitored for 25 weeks. Although voluntary exercise activity was not changed, locomotion capability deteriorated with a latency of 17 weeks after cord compression and worsened progressively. Those characteristics were resembled to clinical spondylotic myelopathy. Motor neuron was counted at 1, 3, 9 and 25 weeks after cord compression. The neuron count decreased in 9 weeks and 25 weeks significantly. The count of 25 weeks after compression was only 66% compared with control groups. We also investigated the changes microvasculature of the spinal cord in this compression model using silicone rubber perfusion technique. At 25 weeks after compression, vein in the white matter and gray matter were dilated and vessels of cord surface were compressed. This suggest that the disturbance of microcirculation in- and/or extramedullary was caused clinical symptom and delayed neuronal loss.
We believe the present model is to help advancement of the neuropathological and neurophysiological studies of the mechanism of cervical myelopathy.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 川本俊樹: "延髄頚髄移行部の出血性病変Posterior Midline Splittingによりどの高位までapproach可能か?"Spine Frontier. 6. 172-180 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 金彪: "多孔性ハイドロキシアパタイトを用いた頚椎前方手術と長期成績"脊椎脊髄. 13. 20-26 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹: "脊髄動静脈奇形と動静脈瘻 病態と治療方針"脊椎脊髄. 12. 477-483 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹: "脳神経外科レビュー8 Extramedullary Lesion,Spine,Peripheral Nerve"三輪書店. 15 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹: "脳神経外科レビュー7 Extramedullary Lesion,Spine,Peripheral Nerve"三輪書店. 17 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹(分担): "神経症候学 脊髄腫瘍、脊髄硬膜外・硬膜内髄外腫瘍"日本臨床. 9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹(分担): "Annual Review神経 脊髄血管障害"中外医学社. 10 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 川本俊樹: "延髄頚髄移行部の出血性病変Posterior Midline Splittingによりどの高位までapproach可能か?"Spine Frontier. 6. 172-180 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 金彪: "多孔性ハイドロキシアバタイトを用いた頚椎前方手術と長期成績"脊椎脊髄. 13. 20-26 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川本俊樹: "脊髄動静脈奇形と動静脈瘻病態と治療方針"脊椎脊髄. 12. 477-483 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川本俊樹: "脳神経外科レビュー8Extramedullary Lesion,Spine,Peripheral Nerve"三輪書店. 15 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川本俊樹: "脳神経外科レビュー7Extramedullary Lesion,Spine,Peripheral Nerve"三輪書店. 17 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川本俊樹(分担): "神経症候学脊髄腫瘍、脊髄硬膜外・硬膜内髄外腫瘍"日本臨床. 9 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 川本俊樹(分担): "Annual Review神経脊髄血管障害"中外医学社. 10 (1999)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kim P,Wakai S,Matsuo S,et al: "Bisegmental Cervical Interbody Fusion with Hydroxyapatite Implants. Surgical Results and Long-term Observation in 70 cases"J Neurosurg.. 88. 21-27 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kim P,Yoshimoto Y,Iino M,et al: "Increased Calcium Permeability of Sarcolemma during Chronic Vasospasm following Subarachnoid Hemorrhage"J Cereb Blood Flow Met. 16. 334-341 (1996)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kim P,Yoshimoto Y,Nakaguchi H,et al: "Increased Sarcolemmal Permeability in the Cerebral Artery during Chronic Spasm. An Assessment using DNA-binding Dyes and Detection of Apoptosis"J Cereb Blood Flow Met. 19. 889-897 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kawamoto T,Ikeda Y,Teramoto A,et al: "Protective Effects of L-histidine (singlet oxygen scavenger)on Transient Forebrain Ischemia,Ischemic and Traumatic Brain Edema in the Rat"Microcirculation Annual. 14. 13-14 (1998)

    • Related Report
      1999 Annual Research Report
  • [Publications] 金 彪、川本 俊樹、朝来野佳三: "多孔性ハイドロキシアパタイトを用いた頚椎前方手術と長期成績"脊椎脊髄. 13. 20-26 (2000)

    • Related Report
      1999 Annual Research Report
  • [Publications] 川本 俊樹、金 彪: "脊髄動静脈奇形と動静脈瘻:病態と治療方針"脊椎脊髄. 12. 477-483 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 川本 俊樹、金 彪: "脊髄血管障害 Annual Review 神経 1999"中外医学社. 10 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 川本 俊樹 金 彪: "Extramedullary Lesion,Spine,Peripheral Nerve 脳神経外科レビュー 7"三輪書店. 17 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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