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Factors affecting human placental transfer of anesthesia-related drugs.

Research Project

Project/Area Number 11470330
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionHYOGO COLLEGE OF MEDICINE

Principal Investigator

TASHIRO Chikara  Hyogo College of Medicine, Professor, 医学部, 教授 (20107048)

Co-Investigator(Kenkyū-buntansha) TSUJIMOTO Saburo  Hyogo College of Medicine, Assistant Professor, 医学部, 講師 (00144254)
MURAKAWA Kazushige  Hyogo College of Medicine, Professor, 医学部, 教授 (70104263)
何 艶玲  兵庫医科大学, 医学部, 助手 (70233640)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥5,900,000 (Direct Cost: ¥5,900,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1999: ¥2,300,000 (Direct Cost: ¥2,300,000)
KeywordsPlacental transfer / placental perfusion / propofol / p-glycoproteion / pharmacokinetics / 薬効動態 / 胎盤透過性 / タンパク結合
Research Abstract

Placental transfer of porpofol in human dually per fused cotyledon in vitro.
We investigated the effects of uterine and umbilical blood flow and albumin concentration (protein binding) on the placental transfer ofpropofol by using the dually per fused human placental cityledon(single pass mode). Placental transfer was evaluated on the basis ofplacental clearaces at various flow rates or albumin concentrations of maternal and fetal perfusates. Antipyrine was added to the maternal perfusate as a reference. As results, (l) With increasing albumin concentrations of the fetal perfusate at constant maternal albumin level, propofol concentrations of fetal perfusate and its clearance were increased while both unbound propofol concentration and antipyrine clearance were unchaged. (2) With increasing albumin concentrations of maternal perfusate, propofol concentration of fetal outflow and placental clearance were decreased. (3) With increasing maternal blood flow, the propofol concentration of fetal out flow was increased while both clearance ofpropofol and antipyrine were increased (clearance ratio was constant). (4) With increasing fetal blood flow, the propofol concentration of fetal out flow was unchanged while clearance of propofol was flow-dependency increased but clearance of antipyrine showed ceiling.(5) Propofol significantly partitioned to placental tissues and the placenta would act as a condenser.In summary, our model could exactly denote the placental transfer of drug using the parameter of clearance while traditional determination of maternal and fetal blood concentration (F/M ratio) was extremely influenced with uterine blood flow, umbilival blood flow, and protein binding in maternal and umbilical blood

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report

Research Products

(16 results)

All Other

All Publications (16 results)

  • [Publications] He YL, Seno H, SasaKi K, Tashiro C: "The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfised cotyledon in vitro"Anesth Analg. 94(4)(In press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Seno H, He YL, Tashiro C, et al.: "Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various rat tissues"J Anesthesia. 16(1). 87-89 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Seno H, Tsujimoto S, Tashiro C.: "The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion"Anesth Analg. 93(1). 151-156 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Tsujimoto S, Tanimoto M, Okutani R, Murakawa k, Tashiro C: "Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro"Br J Anaesth. 85(2). 281-286 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 妹尾浩史, 何艶麗, 太城力良: "プロポフォールの体内動態・薬効に対するシクロスポリンの影響"Pharmacoanesthesiology (日本麻酔薬理学会誌). 13(2). 116-117 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Seno H, Sasaki K, Tashiro C: "The influences of maternal albumin concentraion on the placental transfer of propofol in human dually perfused cotyledon in vitro."Anesth Analg. 94(4)(in press). (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Seno H, HeYL, Tashiro C, Ueyama H, Mashimo T: "Simple high-performance liquid chromatographic assay of propofol in human and rat plasma and various rat tissues."J Anesthsia. 16(1). 87-89 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Seno H, Sasaki K, Tashiro C: "The effects of uterine and umbilical blood flows on the transfer of propofol across the human placenta during in vitro perfusion."Anesth Analg. 93(1). 151-156 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Tsujimoto S, Tanimoto M, Okutani R, Murakawa K, Tashiro C: "Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro."Br Anaesth. 85(2). 281-286 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] He YL, Seno H, SasaKi K, Tashiro C: "The influences of maternal albumin concentrations on the placental transfer of propofol in human dually perfised cotyledon in vitro"Anesth Analg. 94(4)(in press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Seno H, He YL, Tashiro C, et al.: "Simple high-performance liquid chromatographic assay of propofol in human andrat plasma and various rat tissues"J Anesthesia. 16(1). 87-89 (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] He YL, Seno H, Tsujimoto S, Tashiro C: "The effects of uterine and umbilical blood flows on the transfer of propofol across the human placonta during in vitro perfusion"Anesth Analg. 93(1). 151-156 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] He YL, Tsujimoto S, Tanimoto M, Okutani R, Murakawa K, Tashiro C: "Effects of protein binding on the placental transfer of propofol in the human dually perfused cotyledon in vitro"Br J Anaesth. 85(2). 281-286 (2000)

    • Related Report
      2001 Annual Research Report
  • [Publications] 妹尾浩史, 何艶麗, 太城力良: "プロポフォールの体内動態・薬効に対するシクロスポリンの影響"Pharmacoanesthesiology(日本麻酔薬理学会誌). 13(2). 116-117 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] He YL,Tsujimoto S,Tanimoto R,Okutani R,Murakawa K,Tashiro C.: "Effects of protein binding on the placental transfer of propofol in the human dually perfised cotyledon in vitro."Br J Anaesth. 85(2). 281-286 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] YLHe,C Tashiro et al.: "Effects of Protein Binding on the Placental transfer of Propafol in the Human Dually-Perfused Cotyledon"Br.J.Anaerth.. (in press).

    • Related Report
      1999 Annual Research Report

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Published: 1999-03-31   Modified: 2016-04-21  

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