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Research of the regulation pf acute allograft rejection in ABO-blood type incompatible kidney transplantation

Research Project

Project/Area Number 11470333
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionNIIGATA UNIVERSITY

Principal Investigator

TAKAHASHI Kota  NIIGATA UNIVERSITY, Graduate School of Medical and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授 (90101857)

Co-Investigator(Kenkyū-buntansha) SAITO Kazuhide  NIIGATA UNIVERSITY, University Medical Hospital, Assistant professor, 医学部・附属病院, 講師 (20262438)
Project Period (FY) 1999 – 2001
Project Status Completed (Fiscal Year 2001)
Budget Amount *help
¥13,800,000 (Direct Cost: ¥13,800,000)
Fiscal Year 2001: ¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2000: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1999: ¥7,300,000 (Direct Cost: ¥7,300,000)
KeywordsABO-incompatible kidney transplantation / Humoral rejection / Standarization of anti-A / B antibody titre estimation / Elimination of antibodies / Immunosuppressive therapy / Splenectomy / Pathological criteria / Anti-endothelial cell antibody / 抗体価測定標準化 / 病理診断基準 / 抗体除去法 / 周術期管理 / 抗A抗B抗体価 / 抗凝固療法 / 腎血管内皮細胞
Research Abstract

ABO-blood type incompatible kidney transplantation is one of a big challenge to overcome the immunological barrier of humoral rejection caused by acquired natural antibodies. In this study we have achieved "the state of the art" today and published the books entitled "ABO incompatible kidney transplantation". In the article, head investigator Takahashi described about the history, patient and graft survival data update in Japan, antigenic molecules and antibodies, indication and peri-dperacive evaluation and management, immunosuppression, extra-corporeal immuno-modulation, standard operative methods of transplantation and splenectomy, infection control, clinico-pathological research and case reports, and future perspectives. In the article, we also present a new strategy of pathological croteria for allograft rejection in ABO-incompatible kidney transplantation.
In addition, in order to evaluate pre-sensitization status and high risk group for acute rejection in kidney transplantation, we have developed cellular ELISA system to detect anti glomerular endothehal cell antibodies(AECA-GEC) and anti-human umbilical vein endothelial cells(AECA-HUVEG) in kidney transplant recipient serum.
In the sequential serum examination in 22 recipients, AECA-GEC positive group showed significantly high frequency, of acute rejection.episodes This phenomena suggests that AECA-GEC positive status may indicate pre-sensitization status against organ-specific antigens expressed on renal glomerular endothelial cells which might cause the disturbance of microcirculation of the graft leading to acute humoral and cellular rejection.
We also provide a possibility of an new strategy of immunosuppressive therapy including elimination of acquired antibodies and continuous immunosuppression of antibody production by lymphocytes in highly sensitized recipients.

Report

(4 results)
  • 2001 Annual Research Report   Final Research Report Summary
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (62 results)

All Other

All Publications (62 results)

  • [Publications] 高橋公太: "わが国のABO血液型不適合腎移植の統計-第5回アンケート調査報告-"今日の移植. 14・6. 719-733 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuki Nakagawa, et al.: "Serum antibody activity to glomerular endothelial sells is a useful indicator for renal allograft rejection"Taansplantation Proceedings. 33. 3289-3292 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, et al.: "Successful pediatric kidney transplantation from pediatric non-heart beating donors"Transplantation Proceedings. 33. 3781-3782 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi, et al.: "First report of a seven-year survey on ABO -incompatible kidney transplantaiion in Japan"Clinical and Experimental Nephrology. 5. 119-125 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, et al.: "Study of pharmacokinetic parametprs of tacrolimus by different oral administration period in renal transplantation"Transplantation Proceedings. (in press). (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiyuki Ohta, et al.: "Effect of pre-and postperative plasmapheresis on posttransplant recurrence of focal segmental lomerulosclerosis in children"Transplantation. 71,5. 628-633 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "小児の腎移植"日本医師会雑誌. 124(5). 688-688 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "腎移植-21世紀を迎えて何が問題か-"腎と透析. 49・6. 1011-1014 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "腎移植における免疫抑制療法"腎臓. 23(2). 84-93 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "専門外来の実際-腎移植外来-"臨床泌尿器科. 54(4). 330-334 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "腎疾患と血栓-腎移植-"血栓と循環. 8(1). 63-67 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "臓器移植の現況と将来 1)腎移植、膵移植"日本内料学会雑誌. 89(9). 165-170 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西慎一 他: "腎移植とアフェレシス"日本アフェレシス学会雑誌. 20(2). 125-132 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 大田敏之 他: "小児ABO血液型不適合腎移植12例の経験"日本小児腎不全学会雑誌. 21. 46-49 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 齋藤和英 他: "ABO血液型不適合腎移植"G.I.Research. 9(1). 3-10 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi, et al.: "First repdrt of a seven-ydar survey on ABO-incompatible kidney transplantation in Japan"Clinical and Exporimental Nephrology. 5. 119-125 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiyuki Ohta, et al.: "ABO-incompatible pediatric kidney transplantation in a single-center trial"Pediatric Nephrology. 14. 1-5 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太 他: "わが国における新規免疫抑制薬ミコフェノール酸モフェチルの腎移植臨床試"今日の移植. 13(2). 136-139 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, et al.: "Efficacy of Tacrolimus in ABO-incompatible kidney transplantation: Clinicopathological aspect of humoral rejection"Transplantation Proceedings. 31. 2851-2852 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shiro Onitsuka, et al.: "Peritubular capillary deposition of C4d complement fragment in ABO-incompatible renal transplantation with humoral rejection"Clinical Transplantation. 13(suppl.1). 33-37 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 西憤一 他: "アフェレシスの新しい展開(1)臓器移植とアフェレシス"臨床透析. 15(6). 723-728 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高橋公太: "ABO血液型不適合腎移植"今日の移植. 12(6). 642-656 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 中川由紀 他: "血行動態形態異常のため移植困難だった小児献腎移植の1例"小児腎不全学会雑誌. 19. 29-31 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 長谷川友紀 他: "小児腎臓移植レシピエント選択基準についての検討"日本透析医学会誌. 32(11). 1397-1400 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "ABO-incompatible kidney transplantation"Elsevier Science. 154 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi, et al: "First report of a seven-year survey on ABO-incompatible kidney transplantation in Japan"Clinical and Experimental Nephrology. 5. 119-125 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiyuki Ohta, et al: "Effect of pre-and postoperative plasmapheresis on posttransplant recurrence of segmental glomerulosclerosis in children Transplantation"71. 628-633 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuki Nakagawa, et al.: "Serum antibody activity to glomerular endothelial cells is a useful indication for renal allograft rejection"Transplantation Proceedings. 33. 3289-3292 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, et al: "Successful pediatric kidney transplantation from pediatric non-heart-beation donors"Transplantation Proceedings. 33. 3781-3782 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiyuki Ohta, et al.: "ABO-incompatible pediatric kidney transplantation in a single-center trial"Pediatric Nephrology. 14. 1-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, et al.: "Efficacy of tacrolimus in ABO-incompatible kidney transplantation: Clinicopathological aspect of humoral rejection"Transplantation Proceedings. 31. 2851-2852 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shiro Onitsuka, et al: "Peritubular capillary deposition of C4d complement fragment in ABO-incompatible renal transplantation with humoral rejection"Clinical Transplantation 13(suppl. 1). 33-37 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "ABO-incompatible Kidney Transplantation in JAPAN. Report of th e5^<th> Registry of ABO-incompatible Kidney Transplantation"Transplantation Today 14(6). 719-733 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shiniti Nishi, et al.: "Kidney Transplantation and Apheresis"Japanese Journal of Apheresis. 20(2). 125-132 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Toshiyuki Ohta, et al.: "Experience of 12 cases of pediatric ABO-incompativblle kidney transplantation. Workshop: 『Pediatric ABO-incompatible Kidney Transplantation Update』"Japanese Journal of Pediatric Renal Failure. 21. 46-49 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kazuhide Saito, Kota Takahashi: "ABO-Incompatible Kidney Transplantation"G. I. Research. 9(1). 3-10 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "Clinical Trial of New Immunosuppressant Mycophenolate Mofetil In Japan"Transplantation Today. 13; 2. 136-139 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahash: "Pediatric Kidney Transplantation"Journal of the Japan Medical Association. 124; 5. 688 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "Kidney Transplantation -What Is the problem at the beginning of the 21st Century?-"kidney and Dialysis. 49; 6. 1011-1014 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "Immunosuppressive Therapy on Kidney Transplantation"Kidney. 23(2.3). 84-93 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "Out-patient clinic for Kidney Transplant Recipients"Rinsho-Hinyoukika. 54(4). 330-334 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "Kidney Transplantation -Thrombosis and. Circulation-"Thrombosis and Circulation. 8(1). 63-67 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "The 97th Annual Meeting of Japan Society of Internal Medicine -Panel Discussion Organ Transplantation -Update and the Future- 1) Kidney, and Pancreas Transplantation"The Journal of The Japanese Siciety of Internal Medicine. 89(9). 165-170 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "ABO-Incompatible Kidney Transplantation"Report of the 4^<th> Registry of ABO-incompatible Kidney Transplantation. Transplantation Today, 12(6). 642-651 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Shrniti Nishi, et al.: "A New Perspective In Apheresis Therapy"(1) Apheresis and Organ Transplantation Rinsho Touseki. 15(6). 723-728 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Yuki Nakagawa, et al.: "A Case of Pediatric Kidney Transplantation Technical challenging case becausee of the hemodynamic abnormalities"Japanese Journal of Pediatric renal Failure. 19. 29-31 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Tomonori Hasegawa, et al.: "Allocation criteria of Pediatric Kidney Transplant Recipient"Journal of Japanese Society for Dialysis Therapy. 32(11). 1397-1400 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi: "ABO-incompatible Kidney Transplantation Elsevir Science, B.V. Amsterdam"(2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahashi, Koichi Tanaka: A New Strategy of ABO-incompatible Trahsplantation -2001- Japan ABO-incompatible Transplantation Comittee Nihonlgakukan Press, Tokyo. (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] Kota Takahshi: "Organ Transplantation and Medicine. Abstracts of thr 6^<th> Nikko Conference. Immunosuppressive Therapy in Kidney Transplantation Nihon Igakukan Press, 1999, Tokyo"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2001 Final Research Report Summary
  • [Publications] 高 橋 公 太: "わが国のABO血液型不適合腎移植の統計-第5回アンケート調査報告-"今日の移植. 14・6. 719-733 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Yuki Nakagawa, et al.: "Serum antibody activity to glomerular endothelial sells is a useful indicator for renal allograft rejection"Transplantation Proceedings. 33. 3289-3292 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazuhide Saito, et al.: "Successful pediatric kidney transplantation from pediatric non-heart beating donors"Transplantation Proceedings. 33. 3781-3782 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kota Takahashi, et al.: "First report of a seven-year survey on ABO-incompatible kidney transplantation in Japan"Clinical and Experimental Nephrology. 5. 119-125 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kazuhide Saito, et al.: "Study of pharmacokinetic parameters of tacrolimus by different oral administration period in renal transplantation"Transplantation Proceedings. (In Press). (2002)

    • Related Report
      2001 Annual Research Report
  • [Publications] Kota Takahashi: "ABO-incompatible kidney transplantation"Elsevier Science. 154 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 高橋公太: "ABO不適合腎移植-第4回アンケート調査報告"今日の移植. 13・6. 547-559 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kota Takahashi et.al: "First Report of a Seven-Year Surrey on ABO-incompatible kindey transplantation in Japan"Clinical and Experimental Nepbrology. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Yuki Nakagawa et.al: "Serum antibody activity to glomerular endothelial cells is a useful indication for renal allograft rejection"Clinical and Experimental Immunology. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] Kota Takahashi: "ABO incompatible Kidney Transplantation"Elsevir Science. Co. Ltd.(in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 高橋公太 他: "ABO不適合腎移植-アンケート調査結果報告-"今日の移植. 12巻. 642-652 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Kazuhide Saito. et. al: "Efficacy of tacrolimus in ABO-incompatible kidney transplantation Clinicopathological Aspect of Humoal Rejection"Transplantation Proceedings. 31. 2851-2852 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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