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The New Treatments for the Complications of Middle Ear Cholesteatoma

Research Project

Project/Area Number 11470357
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionNagasaki University

Principal Investigator

KOBAYASHI Toshimitsu  Nagasaki University, Professor, 医学部, 教授 (80133958)

Co-Investigator(Kenkyū-buntansha) TANAKA Fujinobu  Nagasaki University, Assistant Professor, 医学部, 助手 (00284688)
KIKUCHI Toshihiko  Nagasaki University, Assistant Professor, 医学部・附属病院, 講師 (70177799)
NAKAO Yoshiaki  Nagasaki University, Assistant Professor, 医学部・附属病院, 講師 (40188884)
WADA Hiroshi  Tohoku University, Professor, 工学部, 教授 (30111264)
神田 幸彦  長崎大学, 医学部・附属病院, 助手 (20264244)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2000: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsLabyrinthine fistulae / Laser / ET plug / Patulous eustachian tube / Cholesteatoma / 中耳真珠腫 / 耳管
Research Abstract

(1) Pathophysiologic study on the labyrinthine fistulae : In the case with dual fistulas to the semicircular canals, suction to one fistula caused remarkable decrease of the cochlear function., especially when the non-suction side of the dual fistulas was dry and dura mater was opened with cerebrospinal fluid (CSF) leak. This result indicated the method of prevention the cochlear damage during the treatment of the labyrinthine fistulae. Namely, continuous irrigation of the fistular site is necessary and if a removal of a portion of one semicircular canal is necessary, it should be obliterated as soon as possible, to prevent inadvertent suction of the interrupted semicircular canal.
(2) Ossicular reconstruction using Er : YAG laser : An experimental study was conducted to examine the safety of Er : YAG laser irradiation to the middle ear, to obtain the basic data concerning to the applicability of the laser to the middle ear surgery. In some experiments in which cochlear wall of the guin … More ea pig was irradiated directly, mild decrease of the cochlear function was observed. Due to this observation, we limited the use of this laser to the manipulation lateral to the stapes. Following these experiments we used the Er : YAG laser in the two clinical cases successfully for the first time in Japan.
(3) The development of a new prosthesis for the patulous eustachian tube and insufficient closure of the eustachian tube : A new prosthesis for the purpose of treating intractable patulous eustachian tube was developed. The new prosthesis is made of thin silicone materials, having 4 different sizes usable according to the size of the eustachian tube of each individual. The standard size has a length of 23mm, largest width of 2.5mm, and the top thickness of 1mm. The overall success rate for the treatment of the patulous eustachian tube was 79%, including the perfect control of the symptoms in 50% of the cases. During the process of development of this new prosthesis, a 3-D reconstructive method of imaging the eustachian tube was developed for the first time. This enabled us to visualize and correctly diagnose the severe cases of patulous eustachian tubes. Less

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 小林俊光 他: "耳管開放症の手術"JOHNS. 17(1). 61-64 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小林俊光: "耳管開放症の診断と治療"日本医事新報. 4002. 33-36 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小林俊光 他: "耳管開放症の診断と治療"耳鼻咽喉科臨床. 93. 199-203 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 吉田晴郎,小林俊光 他: "耳管垂直断CTによる耳管及び耳管周囲組織の解析"Otol Jpn. 10(3). 172-176 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 中尾善亮,小林俊光 他: "中耳手術へのER・YAGレーザーの応用"Otol Jpn. 10(3). 169-171 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 田中藤信,小林俊光 他: "半規管切断時の蝸牛機能-吸引および開頭の影響について-"Otol Jpn. 10. 454 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Nakao Y,Tanaka F, Oku R, Kobayashi T: "The usefulness of Er : YAG lser in middle ear surgery."Otol Jpn. 10. 169-171 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Tanaka F, Tsukasaki N, Oku R, Baba Y, Kobayashi T: "Effect on cochlear function of Interruption of the semicircular canals. -The effect of suction and."Otol Jpn. 10. 454 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi T: "Diagnosis and the treatment of patulous eustachian tube."Pract Otologica (Kyoto). 63. 897-907 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kobayashi T, Takamura H, Baba Y, Kawajiri I, Motokawa K, Takasaki K, Nakao Y, Suetake M: "Surgical treatment of the patulous eustachian tube."JOHNS. 17. 61-64 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshida H, Kobayashi T, Takasaki K, Kanda Y, Nakao Y, Morikawa M, Ishimaru H, Hayashi K: "Evaluation of the eustachian tube and its surrounding structures by vertical CT."Otol Jpn. 10. 172-176 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Yoshida H, Kobayashi T, Morikawa M, Hayashi K, Tsujii H, Sasaki Y: "CT evaluation of the patulous eustachian tube by using the horizontal CT system-Comparison between supine and sitting position."Otol Jpn. 10. 281 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] 小林俊光 他: "耳管開放症の手術"JOHNS. 17(1). 61-64 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小林俊光: "耳管開放症の診断と治療"日本医事新報. 4002. 33-36 (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小林俊光 他: "耳管開放症の診断と治療"耳鼻咽喉科臨床. 93. 199-203 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 吉田晴郎,小林俊光 他: "耳管垂直断CTによる耳管及び耳管周囲組織の解析"Otol Jpn. 10(3). 172-176 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 中尾善亮,小林俊光 他: "中耳手術へのER・YAGレーザーの応用"Otol Jpn. 10(3). 169-171 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] 小林俊光、中尾善亮 他: "耳管開放症に対する経鼓室耳管充填術-耳管ピンの開発"Otol Jpn. 9(4). 477 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 吉田晴郎、小林俊光 他: "耳管開放症の側頭骨ターゲット CT-三次元的再構成による検討"Otol Jpn. 9(4). 295 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 中尾善亮、田中藤信 他: "中耳手術へのEr:YAGレーザの応用"Otol Jpn. 9(4). 327 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] 田中藤信、塚崎尚紀 他: "半規管切断時の蝸牛機能-特に吸引の影響について"Otol Jpn. 9(4). 499 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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