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Experimental Study of Extrauterine Fetal Teatment for Congenital Diaphragmatic Hernia

Research Project

Project/Area Number 11470367
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionAkita University

Principal Investigator

YOSHINO Hiroaki  Akita University, School of Medicine, Instructer, 医学部, 助手 (90182807)

Co-Investigator(Kenkyū-buntansha) HARADA Kenji  Akita University, School of Medicine, Assistant Professor, 医学部, 助教授 (20221509)
HEBIGUCHI Tatsuzo  Akita University, School of Medicine, Assistant Professor, 医学部, 助教授 (00124644)
KATO Tetsuo  Akita University, School of Medicine, Professor, 医学部, 教授 (20004963)
MASATO Sageshima  Akita University, School of Medicine, Assistant Professor, 医学部, 講師 (10153967)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥12,700,000 (Direct Cost: ¥12,700,000)
Fiscal Year 2002: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2001: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2000: ¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 1999: ¥7,300,000 (Direct Cost: ¥7,300,000)
KeywordsArtificial Placenta / Estrauterine fetal incubation / ECMO / Fetal treatment / Congenital diaphragmatic hernia / Lamb / 胎児治療 / 胎児鏡下手術
Research Abstract

We have developed an extrauterine fetal incubation system using V-A ECMO via cervical vessels for the treatment of a fetus with a congenital diaphragmatic hernia. The purpose of this study was to examine the feasibility of extrauterine incubation of an isolated premature fetal lamb in the artificial placenta.
The fetuses were(125〜140 days gestational age) were incubated in an isolated artificial amniotic fluid with VA ECMO.
The fetuses were then removed from the incubator and ventilated through a tracheostomy.
The circulation and respiratory state of fetuses during the incubation to ventilation were evaluated by blood gas analysis and colour Doppler ultrasonographic examinations revealed stablecondition undepended on hemodynaniic change of the ductus arteriosus and foramen ovale.
These resuls may indicate that the cervical VA ECMO can effectively support extrauterine intubation of isolated premature fetuses.

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 吉野裕顕, 加藤哲夫: "先天性横隔膜ヘルニア"臨床婦人科産科. 54. 248-251 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] Hiroaki Yoshino, Tetsuo Kato: "Congenital Diaphragmatic Hernia"Rinsyo Fujinnka 54. 248-251 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] 吉野裕顕: "外科治療の現況と産科へのアドバイスー胸部疾患:先天性横隔膜ヘルニア"臨床産婦人科. 54(3). 248-251 (2000)

    • Related Report
      2000 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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