| Project/Area Number |
11470387
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
SHINODA Hisashi Graduate School of Density, Tohoku University, Professor, 大学院・歯学研究科, 教授 (80014025)
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| Co-Investigator(Kenkyū-buntansha) |
ISOYA Mie Graduate School of Density, Tohoku University, Research Associate, 大学院・歯学研究科, 助手 (80271914)
HAYASHI Haruhide Graduate School of Density, Tohoku University, Professor, 大学院・歯学研究科, 教授 (90107293)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥8,100,000 (Direct Cost: ¥8,100,000)
Fiscal Year 2001: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2000: ¥2,900,000 (Direct Cost: ¥2,900,000)
Fiscal Year 1999: ¥3,400,000 (Direct Cost: ¥3,400,000)
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| Keywords | Circadian rhythm / bone formation / bone resorption / bisphosphonate / calcitonin / diurnal rhythm / suprachiasmatic nucleus / hard tissues / 骨代謝 / ラット / 日内リズム / ビスフォスフォネート / 薬効 |
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| Research Abstract |
In the present study, the significance and the nature of the circadian-rhythmic temporal structure of bone formation and resorption, were investigated in rats in relation to the effect of blockers of bone resorption and formation. Under physiological conditions, both bone formation and resorption followed circadian rhythms with a peak during the light period (resting period of the animal) and with a nadir during the dark period (active period of the animal). The magnitude of the effects of blockers of bone resorption (calcitonin and bisphosphonates) and formation (a large dose of etidronate) also varied diurnally depending on the time of drug administration or the time of observation of the drug effect, which indicatess that the susceptibility of the target site (the process of bone resorption or formation) to the drugs also varied diurnally. Furthermore, tooth movement and changes in periodontal tissue response to orthodontic force and response of mandible to orthopedic force in rats varied depending on the time of day the force was applied. The above findings should prove to be important, not only in future experimental design and interpretation of the data, but also in the efficacious use of drugs or efficacious medical or dental treatments which affect bone resorption and bone formation.
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