| Project/Area Number |
11470398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
病態科学系歯学(含放射線系歯学)
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| Research Institution | NAGASAKI UNIVERSITY |
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Principal Investigator |
NAKAMURA Takashi NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, PROFESSOR, 歯学部, 教授 (30172406)
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| Co-Investigator(Kenkyū-buntansha) |
TASHIRO Shigeki NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, INSTRUCTOR, 歯学部, 助手 (20300882)
SHIBATA Yoshiyuki NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, INSTRUCTOR, 歯学部, 助手 (20253685)
SUMI Misa NAGASAKI UNIVERSITY, SCHOOL OF DENTISTRY, ASSISTANT PROFESSOR, 歯学部・附属病院, 講師 (90284702)
泉 雅浩 長崎大学, 歯学部・附属病院, 講師 (40212956)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥14,800,000 (Direct Cost: ¥14,800,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥4,200,000 (Direct Cost: ¥4,200,000)
Fiscal Year 1999: ¥8,100,000 (Direct Cost: ¥8,100,000)
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| Keywords | Salivary gland / Sjogren's Syndrome / MRI / Diffusion-weighted / HAM / Salivary flow / inflammation / sialography / Nitric Ovide / sibgren's syndrome / NO / 唾液 / シェーグレン症候群 / 月経周期 |
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| Research Abstract |
The parotid and submandibular glands in ll (92 %) of the 12 HAM patients with Sjogren's syndrome completely lacked the abnormal imaging features characteristic of the disease, while they displayed decreased salivary flow rates at levels similar to those in the HAM-negative patients with Sjogren's syndrome. The labial glands from the HAM patients with Sjogren's syndrome exhibited significantly lower magnitudes of mononuclear cell aggregation compared with those in the HAM-negative patients with Sjogren's syndrome. In contrast, all HAM-negative patients with Sjogren's syndrome showed abnormal imaging features characteristic of the disease, and the severity in salivary dysfunction correlated well with the imaging findings. These results suggest that Sjogren's syndrome in HAM patients may at least in part occur via a distinctive mechanism from classical Sjogren's syndrome in HAM-negative patients.
The apparent diffusion coefficient was lower in the parotid glands (0.28 x 10^<-3> mm^2/sec) than that of the submandibular glands (0.37 x 10^<-3>mm^2/sec). The apparent diffusion coefficient was increased in sialoadenitis, whereas it decreased with abscess formation. The apparent diffusion coefficients of the parotid glands in patients with Sjogren's syndrome correlated with the salivary flow rates, but not with the sialographic gradings of the glands. We also found a correlation of the decreases in apparent diffusion coefficients with the severity of gland damage as assessed on T1 -weighted MR images. Diffusion-weighted echo-planar MR imaging may reflect diseased states of the salivary glands.
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