| Project/Area Number |
11470439
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
OHISHI Masamichi Faculty of Dental Science, Kyushu University, Prof., 歯学研究院, 教授 (70037505)
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| Co-Investigator(Kenkyū-buntansha) |
AYUKAWA Yasunori Faculty of Dental Science, Kyushu University, Res. Associate, 歯学研究院, 助手 (50304697)
NAKAMURA Nirifumi Dental Hospital, Kyushu University, Assistant Prof., 歯学部・附属病院, 講師 (60217875)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥4,700,000 (Direct Cost: ¥4,700,000)
Fiscal Year 2001: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 2000: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1999: ¥3,100,000 (Direct Cost: ¥3,100,000)
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| Keywords | cleft lip / palate / cleft jaw / autogenous bone / hydroxtapatite mixed graft / implant |
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| Research Abstract |
An advantage of the graft material of 1 : 1 mixture of particulate cancellous bone and marrow (PCBM) and hydroxyapatite (HA) to the defect area of cleft lip and palate was examined. As a result, PCBM alone as a graft material decreased its height in a time-dependent manner, however, the extent was significantly less in PCBM-HA graft material. In other words, PCBM-HA mixture was a possible graft material for cleft lip and palate subjects. In order to further evaluate the effectiveness of PCBM-HA graft material, we examined the tissue response to the graft material using rabbit artificial bone defect model with histological and histometrical procedures and we also obtain the effect of PCBM-HA graft material. In addition, we evaluated the possibility of implant installation to the PCBM-HA graft material. Sixty days after the graft material application, implant was installed and tissue response was observed. As a result, direct contact between the implant and the bone could be observed and the possibility of the implant treatment to the PCBM-HA graft area was confirmed. We plan further research about the temporal change of the interface between the bone and the implant which is installed in the PCBM-HA graft material with the intervention of occlusal force.
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