| Project/Area Number |
11480014
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
体育学
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| Research Institution | Fukuoka University |
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Principal Investigator |
TANAKA Hiroaki Fac. of Sports & Health Science, Professor, スポーツ科学部, 教授 (00078544)
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| Co-Investigator(Kenkyū-buntansha) |
KUROIWA Ataru School. of Medicine, Associate Professor, 医学部, 助教授 (30122691)
SHINDO Munehiro Fac. of Sports & Health Science, Professor, スポーツ科学部, 教授 (30078539)
KIYONAGA Akira Fac. of Sports & Health Science, Professor, スポーツ科学部, 教授 (70177955)
SHONO Naoko Saga Medical School, Lecture, 講師 (60223674)
IKEDA Masaharu Univ. Occupational & Environmental Health, Professor, 教授 (40078770)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥14,400,000 (Direct Cost: ¥14,400,000)
Fiscal Year 2001: ¥4,800,000 (Direct Cost: ¥4,800,000)
Fiscal Year 2000: ¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1999: ¥5,500,000 (Direct Cost: ¥5,500,000)
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| Keywords | VO2max / Lactate threshold / Training / NOx / Capillary / 乳酸闘値(LT) / Nox / SAGE法 / 高血圧 / 乳酸閾値 / NOX / NOS / 最大酸素摂取量、 / 乳酸閾値、 / NOX、 / NOS, / トレーニング、 |
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| Research Abstract |
Based on the hypotheses that common pathological cause of type2 diabete5, hypercholesteremia, heart disease, and hypertension might be due to abnormality of function and structure in endothelial cell and skeletal muscle, we measured the parameters of the function and structure in endothelial cell and skeletal muscle by histochemical, biochemical, molecularbiological methods and investigated the effect of mild exercise training at lactate threshold on the parameters and risk factors of common disease. Obtained results are as follows. 1.A significant correlation between VO2max and basal levels of NOx was found. 2.Although we observed the existence of both the eNOS and iNOS in human skeletal muscle using histochemical method, the change in these enzymes after the training was not large enough to be detected. 3.The blood level of serum NOx did not change after a single bout of mild exercise. 4.6-wk training significantly augmented both the basal level of serum NOx and capillary density in human skeletal muscle. The changes in capillary density were related to change in blood lipid profile. 5.Eleyated basal level of NOx after 6-wk of mild training returned to the pre-training level after the long-term (12-wk) training. We also found that long-term training did not change NOx level in elderly. 6.The 6-wk training tended to increase forearm reactive hyperernia and basal IGFBP-l level, and improve insulin resistance. 7.We confirmed that the training significantly increased LT and decreased both the systolic and diastolic blood pressure in patients with hypertension. Based on these results, we conclude that mild exercise training at LT can improve the ability of endothelial-dependent vasodilation and insulin resistance in its early stages and these improvements may be associated with the risk reduction of common disease.
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