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Morphological survey of Prolactin Releasing Peptide (PrRP) and PrRP receptor with special reference to functional roles of PrRP in the brain

Research Project

Project/Area Number 11480240
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

IBATA Yasuhiko  Kyoto Prefectural University of Medicine, President, 学長 (10079684)

Co-Investigator(Kenkyū-buntansha) KITADA Chieko  Takeda Chemical Industries, LTD, Research Manager, 医薬開拓研究本部, リサーチ・マネージャー
IIJIMA Norio  Kyoto Prefectural University of Medicine, Research associate, 医学部, 助手 (00285248)
TANAKA Masaki  Kyoto Prefectural University of Medicine, Associate professor, 医学部, 助教授 (80264753)
HINUMA Shuji  Takeda Chemical Industries, LTD, Research Head, 医薬開拓研究本部, 主席研究員
玉田 喜堂  京都府立医科大学, 医学部, 講師 (60254364)
林 誠二  京都府立医科大学, 医学部, 助手 (10285249)
松田 知之  京都府立医科大学, 医学部, 助手 (30281265)
Project Period (FY) 1999 – 2000
Project Status Completed (Fiscal Year 2000)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 2000: ¥5,400,000 (Direct Cost: ¥5,400,000)
KeywordsPrRP / in situ hybridization / immunohistochemistry / projection / neuroendocrinology / estrogen / progesteron / somatostatin / 神経ペプチド
Research Abstract

1 PrRP-immunoreactive nerve fibers and terminals were located in the vicinity of the somatostatin(SOM)-neurons in the hypothalamic periventricular nucleus (PerVN). Some parts of SOM-neurons in the PerVN expressed PrRP receptor mRNA. Intracerebroventricular administration of PrRP decreased plasma Growth Hormone levels. From these finding it was suggested that SOM-neurons respond to PrRP and secreted SOM into the portal vessel and thus inhibit GH secretion from the anterior pituitary.
2 PrRP gene expression is regulated by gonadal steroid hormones in the medulla oblongata, and parts of PrRP synthesizing neurons are considered to be directly influenced by estrogen.
3 PrRP mRNA was expressed in the nucleus of solitary tract at embryonic day 18,on the other hand, PrRP mRNA in the hypothalamus was first expressed at postnatal day 13.

Report

(3 results)
  • 2000 Annual Research Report   Final Research Report Summary
  • 1999 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Amaya F.Tanaka M, Hayashi S.Tanaka Y.Ibata Y.: "HPA axis sensitization after chronic salt loading-Hypothalamic VP and CRH regulation-."Neuroendocrinol.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kataoka et al.: "Gonadal regulation of prolactin releasing peptide (PrRP mRNA expression in the nucleus tractus solitarius and ventral and lateral retucular nuclei of rat."Mol Brain Res.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirofuji C et al.: "Cell size and succinate dehydrogenaso activity of different type of bers in different regions of the tibialis anterior muscle in mice and rats."Acta Histochem Cytochem. 33. 295-303 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hinuma S et al.: "Novel Bioactive RFamide-Related Peptides and Their Receptor in Mammals."Nature Cell Biol.. 2. 703-708 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Munekawa K et al.: "Development of astroglial elements in the suprachiasmatac nucleus of the rat with special reference to the involvement of the optic nerve."Exp Neural. 166. 44-51 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ibata Y et al.: "Morphological survey of Prolactin Releasing Peptide (PrRP) and PrRP receptor with special reference to functional roles of PrRP in the brain."Neurosci Res. 38. 223-230 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amaya F, Tanaka M, Hayashi S, Tanaka Y, Ibata Y.: "HPA axis Sensitization after chronic salt loading-Hypothalamic VP and CRH regulation-."Neuroendocrinol.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Kataoka et al.: "Gonadal regulation of prolactin releasing peptide (PrRP) mRNA expression in the nucleus tractus solitarius and ventral and lateral reticular nuclei of rat."Mol Brain Res.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hirofuji C et al.: "Cell size and succinate dehydrogenase activity of different type of fibers in different regions of the tibialis anterior muscle in mice and rats."Acta Histochem Cytochem. Vol.33. 295-303 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Hinuma S et al.: "Novel Bioactive RF amide-Related Peptides and Their Receptor in Mammals."Nature Cell Biol.. Vol.2. 703-708 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Munekawa K et al.: "Development of astroglial elements in the suprachiasmatic nucleus of the rat with special reference to the involvement of the optic nerve."Exp. Neurol. Vol.166. 44-51 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Ibata Y et al.: "Morphological survey of Prolactin Releasing Peptide (PrRP) and PrRP receptor with special reference to functional roles of PrRP in the brain."Neurosci.Res.. Vol.38. 223-230 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2000 Final Research Report Summary
  • [Publications] Amaya F,Tanaka M,Hayashi S,Tanaka Y,Ibata Y.: "HPA axis sensitization after chronic salt loading-Hypothalamic VP and CRH regulation-."Neuroendocrinol.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Kataoka et al.: "Gonadal regulation of prolactin releasing peptide (PrRP) mRNA expression in the nucleus tractus solitarius and ventral and lateral reticular nuclei of rat. Mol Brain Res.(in press)"Mol Brain Res.. (in press).

    • Related Report
      2000 Annual Research Report
  • [Publications] Hirofuji C et al.: "Cell size and succinate dehydrogenase activity of different type of fibers in different regions of the tibialis anterior muscle in mice and rats."Acta Histochem Cytochem. 33. 295-303 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Hinuma S et al.: "Novel Bioactive RFamide-Related Peptides and Their Receptor in Mammals."Nature Cell Biol. 2. 703-708 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Munekawa K et al: "Development of astroglial elements in the suprachiasmatic nucleus of the rat : with special reference to the involvement of the optic nerve."Exp Neural. 166. 44-51 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] Ibata Y et al.: "Morphological survey of Prolactin Releasing Peptide (PrRP) and PrRP receptor with special reference to functional roles of PrRP in the brain."Neurosci Res. 38. 223-230 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] N.Iijima et al.: "Cytochemical study of prolactin-releasing peptide(PrRP) in the rat brain"NeuroReport. 10. 1713-1716 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M Tanaka et al.: "Molecular and functional remodeling of electrogenic membrane of hypothalamic neurons in response to change in their input"Proc.Natl.Acad.Sci.USA. 96. 1088-1093 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Iijima et al.: "Expression of Serine protease(motopsinPRSS12)mRNA in the mouse brain : in situ hybridization histochemical study"Mol.Brain Res.. 66. 141-149 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] Y.Matsumoto: "Morphological and Functional Roles of Macrophages and Postganglionic Sympathetic Fibers in Dorsal Root Ganglions of a Rat Neurophic Pain Modal"Acta Histochem.Cytochem.. 32. 85-93 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] N.Iijima: "Expanded expression of heme oxygenase-1(Ho-1)in the hypothalamic median eminence of aged as compared with young rat"Neuroscience Letters. 271. 113-116 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] M Tanaka: "NGF-IA gene expression induced in the rat suprachiasmatic nuckus by photic stimulation"Europ. J. Neuroscience. 11. 3178-3184 (1999)

    • Related Report
      1999 Annual Research Report

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Published: 2000-04-01   Modified: 2016-04-21  

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