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Control of Aging by the use of Artificial Organs

Research Project

Project/Area Number 11480253
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku university

Principal Investigator

YAMBE Tomoyuki  Institute of Development Aging and Cancer associate professor, 加齢医学研究所, 助教授 (70241578)

Co-Investigator(Kenkyū-buntansha) SAIJO Yoshifumi  Institute of Development Aging and Cancer Research assistant, 加齢医学研究所, 助手 (00292277)
NITTA Shin-ichi  Institute of Development Aging and Cancer Professor, 加齢医学研究所, 教授 (90101138)
YOSHIZAWA Makoto  Information Synergy Center Professor, 情報シナジーセンター, 教授 (60166931)
TABAYASHI Kou-ichi  Graduate School of Medicine Professor, 大学院・医学研究科, 教授 (90142942)
TANAKA Akira  Graduate School of Engineering Research assistant, 大学院・工学研究科, 助手 (10323057)
Project Period (FY) 1999 – 2002
Project Status Completed (Fiscal Year 2002)
Budget Amount *help
¥11,200,000 (Direct Cost: ¥11,200,000)
Fiscal Year 2002: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 2001: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 2000: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1999: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsAging / Chaos control / Total artificial heart / Chaos / Fractal / Automatic control / Fluctuations / 1 / f / 加齢現象、 / カオス制御、 / 全人工心臓、 / カオス、 / フラクタル、 / 自動制御、 / ゆらぎ、
Research Abstract

Since an aging society comes unescapable, we cope with various diseases by the Aging, and have the necessity of aiming at the society where healthy elderly people play an active part. Although an Aging phenomenon can also be considered to be change of the whole body, in the medical spot, it servers as generating of the illness of an internal-organs unit. The illnesses of an internal-organs unit are various medicines and adaptation of a surgical operation. To the internal-organs malfunction which has advanced irreversibl, radical correspondence of transplantation, an artificial organ, etc. becomes indispensable to life maintenance. Therefore, a possibility that support of high-tech medical treatments, such as an articial organ, will become unescapable at the healthy aging society is high. It is becoming old memory with collapse of the Communist bloc that the long-term struggle for existence of the animal experiment of an artificial heart was performed having applied national prestige al … More l over the world. There is an opinion about which it whispered between the artificial heart researchers in the world from that time. It is "aging of the animal after implanting an artificial heart is early ?" It is the hypothesis to say. To pathophysiological change which can be regarded also as promotion of such an Aging after implanting an artificial heart, the syndrome of a "artificial heart syndrome" was proposed in the University of Tokyo. Research on change of the heart blood vessel system in connection with various artificial circulation and Agings has been done even in Tohoku University. The Institute of Development, Aging and Cancer in Tohoku University carried out the research subject "the nonlinear analysis of the artificial heart animal as an Aging promotion model" by the support of the test research from the Ministry of Education science research cost. Cousequently, the artificial heart chronic animal as an Aging promotion model was established. Based on this result, the Ministry of Education, Culture, Sports, Science and Technology science research cost base research "research on control of the Aging phenomenon by chaos control of an artificial organ" was done from 1999 to 2003. Our results suggested the feasibility of control of Aging by the use of the artificial organs. Less

Report

(5 results)
  • 2002 Annual Research Report   Final Research Report Summary
  • 2001 Annual Research Report
  • 2000 Annual Research Report
  • 1999 Annual Research Report
  • Research Products

    (39 results)

All Other

All Publications (39 results)

  • [Publications] T.Tambe: "A future prediction type artificial heart system"Artif Organs. 23. 268-273 (1999)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Totally implantable ventricular assist system which can increase the brain blood flow"Artif Organs. 23. 644-647 (2000)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Theatment of the multiple orgam failure by the use of the totally implantable ventricular assist device"J Artif Organs. 4. 252-256 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Fluctuations of Emax of the left ventricle : effect of atrial natriuretic polypeptide"Biomed Pharmacother. 55. 147-152 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Nonlinear Dynamical Analysis Of The Hemodynamic Parameters With An Undulation Tepe"Biomed Pharmacother. 56. 364-366 (2002)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Recent progress in artificial organ research at Tohoku University"Artif Organs. 27. 2-7 (2003)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe: "Searching for the origin of chaos"IEEE EMBS book. 32 (2001)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.,Yambe, N.Tanizuka, A.Tanaka, M.Yoshizawa, K.Aabe, H.Takeda, K.Tabayashi, S.Nitta: "A future prediction type artificial heart system"Artif 0rgans. 23. 268-273 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, N.Owada, A.Tanaka, S.Kobayashi, S.Nanka, T.Fukuju, K.Tabayashi, M.Yoshizawa, H.Hashimoto, S.Nitta: "Totally implantable ventricular assist system which can increase the brain blood flow"Artif Organs. 23. 644-647 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, N.Owada, S.Kobayashi, S.Nanka, A.Tanaka, M.Yoshizawa, K.Tabe, K.Tabayashi, H.Takeda, H.Hashimoto, S.Nitta: "Treatment of the multiple orgam failure by the use of the totally implantable ventricular assist device"J Artif Organs. 4. 252-256 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, M.Yoshizawa, R.Taira, A.Tanaka, K.Tabayashi, S.Tobita, S.Nitta: "Fluctuations of Emax of the left ventricle: effect of atrial natriuretic polypeptide"Biomed Pharmacother. 55. 147-152 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, Y.Abe, T.Isoyama, K.Tabayashi, S.Nanka, K.Imachi, S.Nitta: "Nonlinear Dynamical Analysis Of The Hemodynamic Parameters With AnUndulation Type Artificial Heart System"Biomed Pharmacother. 56. 364-366 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, M.Yoshizawa, A.Tanaka, K.Abe, S.Kawano, H.Matsuki, S.Maruyama, S.Amae, N.Wada, T.Kamiyama, T.Takagi, Y.Luo, J.Hayashi, Y.A.Kovalev, DXA Sha, S.Nanka, Y.Saijo, Y.Mibiki, M.Shibata, S.Nitta: "Recent progress in artificial organ research at Tohoku University"Artif Organs. 27. 2-7 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, M.Yoshizawa, K.Tabayashi, S.Nitta: "Searching for the origin of chaos"Nonlinear Biomedical Signal Processing. IEEE EMBS book series, In M.Akay ed.. 40-72 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      2002 Final Research Report Summary
  • [Publications] T.Yambe, et al.: "Nonlinear Dynamical Analysis Of The Hemodynamic Parameters With An Undulation Type Artificial Heart System"Biomed Pharmacother. 56. 364-366 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yambe, et al.: "Development of new diagnosis tool for evaluating autonomic function during virtual reality immersion"Jpn J Applied Physiology. 32. 255-258 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yambe, et al.: "Nonlinear dynamical analysis of the hemodynamic behaviors during the virtual reality immersion"Biomed Pharmacother. 56. 367-369 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yambe, et al.: "Correlation dimension of the artificial Circulation"J Artif Organs. 5. 1-5 (2002)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yambe, et al.: "Recent progress in artificial organ research at Tohoku University"Artif Organs. 27. 2-7 (2003)

    • Related Report
      2002 Annual Research Report
  • [Publications] T.Yambe, M.Yoshizawa, A.Tanaka, K.Tabayashi, S.Nitta: "Fluctuation of E max of the left ventricle : effect of atrial natriuretic polypepetide"Biomed Pharmacother. Vol.55. 147-152 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山家智之 吉澤誠 田中明 田林晄一 仁田新一: "Effect of Atrial Natriretic Polypeptide on the Fluctuations of Emax of the Left Ventricle"Therapeutic research. Vol.22 No.7. 5-10 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Yambe, A.Tanaka, M.Yoshizawa, K.Tabayashi, S.Nitta: "Pathophysiological aspect of an implantable ventricular assist device with short stroke and high frequency"Journal of Congestive Heart Failure and Circulatory Support. Vol.1 No.4. 259-262 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Yambe, S.Nitta, M.Yoshizawa, K.Tabayashi: "Smallest ventricular assist system by use of peltier elements with shape memory alloy"Journal of Congestive Heart Failure and Circulatory Support. Vol.1 No.4. 403-405 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] 山家智之 吉澤誠 田中明 田林晄一 仁田新一: "人工血圧反射によって発生する決定論的カオス"日本臨床整理学会雑誌. 第31巻 第5号. 261-264 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Ymbe, S.Nitta, M.Yoshizawa, K.Tabayashi: "Treatment of multiple organ failure by a totally implantable ventricular assist device"J Artif Organs. Vol.4. 252-256 (2001)

    • Related Report
      2001 Annual Research Report
  • [Publications] T.Yambe, et al.: "Pathological aspect of an implantable ventricular assist device with short stroke and high frequency."Artificial Heart 7, Tokyo-Springer-Verlag,. (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yambe, et al.: "Totally implantable ventricular assist system which can increase the brain blood flow."Artif Organs. 23. 644-647 (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T,Yambe, et al.: "Smallest ventricular assist system by the use of the peltier elements with the shape memory alloy"Artificial Heart 7, Tokyo-Springer-Verlag. (in press). (2000)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yambe, et al.: "Autonomic nurve function during left ventricular assistance with totally implantable vibrating flow type ventricular assist device."Artif Organs. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yambe, et al.: "Evaluation of the cardiac function by chaos theory"Artif Organs. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yambe, et al.: "Arterilinput impedance pattern over 10Hz"Artif Organs. (in press). (2001)

    • Related Report
      2000 Annual Research Report
  • [Publications] T.Yamabe: "A future prediction type artificial heart system"Artif Organs. 23. 268-273 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Detection of cardiac function by the fractal dimension analysis"Artif Organs. 23. 751-756 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Peripheral vascular resistances during total left heart bypass with an oscillated blood flow"Artif Organs. 23. 747-750 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Vagal nerve activity in the awake condition for the control of an artificial heart system"Artif Organs.. 22. 324-328 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Totally implantable ventricular assist system which can increase the brain blood flow"Artif Organs. (in press)

    • Related Report
      1999 Annual Research Report
  • [Publications] 山家智之: "カオスの応用による加齢現象の加速と制御"日本臨床生理学会雑誌. 29. 333-340 (1999)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Evaluation of cardiac function by the nonlinear mathematics."ILAS press. (inpress)

    • Related Report
      1999 Annual Research Report
  • [Publications] T.Yamabe: "Parasympathetic nerve activity in the awake condition for the control of an artificial heart system"ILAS press. (inpress)

    • Related Report
      1999 Annual Research Report

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Published: 1999-04-01   Modified: 2016-04-21  

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