| Project/Area Number |
11555242
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 展開研究 |
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| Research Field |
Synthetic chemistry
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
YOSHIDA Jun-ichi Graduate School of Engineering, Kyoto University, Professor, 工学研究科, 教授 (30127170)
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| Co-Investigator(Kenkyū-buntansha) |
SUGA Seiji Graduate School of Engineering, Kyoto University, Professor, 工学研究科, 講師 (50291430)
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| Project Period (FY) |
1999 – 2001
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| Project Status |
Completed (Fiscal Year 2001)
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| Budget Amount *help |
¥13,500,000 (Direct Cost: ¥13,500,000)
Fiscal Year 2001: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 2000: ¥3,600,000 (Direct Cost: ¥3,600,000)
Fiscal Year 1999: ¥6,200,000 (Direct Cost: ¥6,200,000)
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| Keywords | Electron Transfer / Cation Pool Method / Cation Flow Method / Combinetorial Synthesis / 電子移動駆動型反応 / 炭素カチオン / 炭素求核剤 / 炭素-炭素結合形成 / 炭素―炭素結合形成 |
|---|
| Research Abstract |
We aimed to develop a practical electron transfer driven reaction for organic synthesis, and a "cation flow"method has been developed on the basis of the "cation pool" method. In the "cation flow" method, carbocations generated using a low temperature electrochemical microflow reactor were immediately trapped with carbon nucleophies. Downsizing of a electrochemical flow reactor enables efficient temperature control and shortening ofa residence time, and thus an application of this system to less stable carbocation could be possible. We have also developed a direct analysis system of the flow of the carbocations using FITR spectrometer. More outstanding feature of the "cation flow" system is that continuous sequential combinatorial synthesis can be accomplished by simple flow switching. Although parallel syntheses enjoy versatile applications in combinatorial chemistry, the present continuous sequential method opens a new intriguing aspect of combinatorial synthesis.
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